PIK3CB promotes oesophageal cancer proliferation through the PI3K/AKT/mTOR signalling axis
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11847
Abstract: PIK3CB is abnormally expressed in various carcinomas and affects the proliferation, invasion and drug resistance of cancer cells. However, its role in oesophageal squamous cell carcinoma (ESCC) is still unclear. In this study, PIK3CB was… read more here.
Keywords: mtor signalling; pi3k akt; escc; pik3cb ... See more keywords
GSK3 and its interactions with the PI3K/AKT/mTOR signalling network.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in biological regulation"
DOI: 10.1016/j.jbior.2017.06.003
Abstract: Glycogen Synthase Kinase-3 (GSK3 or GSK-3) is a promiscuous protein kinase and its phosphorylation of its diverse substrates has major influences on many areas of physiology and pathology, including cellular metabolism, lineage commitment and neuroscience.… read more here.
Keywords: phosphorylation; pi3k akt; gsk3; mtor signalling ... See more keywords
Immunohistochemical expression of selected phosphoproteins of the mTOR signalling pathway in canine cutaneous squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2019 at "Veterinary journal"
DOI: 10.1016/j.tvjl.2018.12.024
Abstract: Cutaneous squamous cell carcinoma (cSCC) represents one of the most common malignant skin tumors in dogs. Research aimed at clarifying how the deregulated activity of signalling pathways contributes to cSCC progression can help to identify… read more here.
Keywords: squamous cell; signalling pathway; mtor signalling; expression ... See more keywords
Kinome-wide analysis of the effect of statins in colorectal cancer.
Sign Up to like & getrecommendations! Published in 2021 at "British journal of cancer"
DOI: 10.1038/s41416-021-01318-9
Abstract: BACKGROUND Epidemiological studies and meta-analyses show an association between statin use and a reduced incidence of colorectal cancer (CRC). We have shown that statins act on CRC through bone morphogenetic protein (BMP) signalling, but the… read more here.
Keywords: analysis; colorectal cancer; effect; mtor signalling ... See more keywords
mTOR signalling and cellular metabolism are mutual determinants in cancer
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Cancer"
DOI: 10.1038/s41568-018-0074-8
Abstract: Oncogenic signalling and metabolic alterations are interrelated in cancer cells. mTOR, which is frequently activated in cancer, controls cell growth and metabolism. mTOR signalling regulates amino acid, glucose, nucleotide, fatty acid and lipid metabolism. Conversely,… read more here.
Keywords: metabolism; mtor signalling; mtor; cancer ... See more keywords
mTOR at the nexus of nutrition, growth, ageing and disease
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Molecular Cell Biology"
DOI: 10.1038/s41580-019-0199-y
Abstract: The mTOR pathway integrates a diverse set of environmental cues, such as growth factor signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half decades, mapping of the mTOR… read more here.
Keywords: mtor pathway; mtor nexus; disease; mtor signalling ... See more keywords
Emerging role and therapeutic implication of mTOR signalling in intervertebral disc degeneration
Sign Up to like & getrecommendations! Published in 2022 at "Cell Proliferation"
DOI: 10.1111/cpr.13338
Abstract: Intervertebral disc degeneration (IDD), an important cause of chronic low back pain (LBP), is considered the pathological basis for various spinal degenerative diseases. A series of factors, including inflammatory response, oxidative stress, autophagy, abnormal mechanical… read more here.
Keywords: mtor signalling; mtor; disc degeneration; intervertebral disc ... See more keywords
mTOR signalling pathway in stem cell bioactivities and angiogenesis potential.
Sign Up to like & getrecommendations! Published in 2023 at "Cell proliferation"
DOI: 10.1111/cpr.13499
Abstract: The mammalian target of rapamycin (mTOR) is a protein kinase that responds to different stimuli such as stresses, starvation and hypoxic conditions. The modulation of this effector can lead to the alteration of cell dynamic… read more here.
Keywords: mtor signalling; mtor; cell bioactivities; stem cell ... See more keywords
PBRM1 deficiency oncogenic addiction is associated with activated AKT–mTOR signalling and aerobic glycolysis in clear cell renal cell carcinoma cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17418
Abstract: The PBRM1 (PB1) gene which encodes the specific subunit BAF180 of the PBAF SWI/SNF complex, is highly mutated (~ 40%) in clear cell renal cell carcinoma (ccRCC). However, its functions and impact on cell signalling are… read more here.
Keywords: mtor signalling; cell; akt mtor; clear cell ... See more keywords
L-arginine stimulates the proliferation of mouse mammary epithelial cells and the development of mammary gland in pubertal mice by activating the GPRC6A/PI3K/AKT/mTOR signalling pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of animal physiology and animal nutrition"
DOI: 10.1111/jpn.13730
Abstract: Amino acids have been shown to affect the development of mammary gland (MG). However, it is unclear whether L-arginine promotes the development of pubertal MG. Therefore, our study aims to explore the effect of L-arginine… read more here.
Keywords: mtor signalling; pi3k; pubertal mice; development ... See more keywords
LINC01278 Induces Autophagy to Inhibit Tumour Progression by Suppressing the mTOR Signalling Pathway
Sign Up to like & getrecommendations! Published in 2023 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2023/8994901
Abstract: Uveal melanoma (UM) is an aggressive intraocular malignant tumour that is closely related to autophagic dysfunction. We aimed to identify autophagy-related long noncoding RNAs (lncRNAs) to elucidate the molecular mechanism of UM. Here, we show… read more here.
Keywords: mtor signalling; induces autophagy; linc01278 induces; autophagy inhibit ... See more keywords