TSC2/Rheb signaling mediates ERK‐dependent regulation of mTORC1 activity in C2C12 myoblasts
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12195
Abstract: The enhanced rate of protein synthesis in skeletal muscle cells results in a net increase in total protein content that leads to skeletal muscle growth/hypertrophy. The mitogen‐activated protein kinase kinase (MEK)/extracellular signal‐regulated kinase (ERK)‐dependent regulation… read more here.
Keywords: c2c12 myoblasts; mtorc1; activation; erk dependent ... See more keywords
Significant impact of mTORC1 and ATF4 pathways in CHO cell recombinant protein production induced by CDK4/6 inhibitor.
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DOI: 10.1002/bit.28050
Abstract: The CDK4/6 inhibitor has been shown to increase recombinant protein productivity in Chinese hamster ovary cells (CHO). Therefore, we investigated the mechanism that couples cell cycle inhibitor (CCI) treatment with protein productivity utilizing proteomics and… read more here.
Keywords: recombinant protein; phosphorylation; mtorc1; cdk4 inhibitor ... See more keywords
DEP domain–containing mTOR–interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute‐on‐chronic liver injury in alcoholic liver disease
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DOI: 10.1002/hep.29849
Abstract: Alcoholic liver disease (ALD) is characterized by lipid accumulation and liver injury. However, how chronic alcohol consumption causes hepatic lipid accumulation remains elusive. The present study demonstrates that activation of the mechanistic target of rapamycin… read more here.
Keywords: liver; mtorc1; mtor; liver injury ... See more keywords
RNA helicase DEAD‐box protein 5 alleviates nonalcoholic steatohepatitis progression via tethering TSC complex and suppressing mTORC1 signaling
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32651
Abstract: Background and Aims: Nonalcoholic fatty liver disease and its progressive form, nonalcoholic steatohepatitis (NASH), are rapidly becoming the top causes of hepatocellular carcinoma (HCC). Currently, there are no approved therapies for the treatment of NASH.… read more here.
Keywords: ddx5; mtorc1; dead box; nonalcoholic steatohepatitis ... See more keywords
mTORC1 Inhibits NF‐κB/NFATc1 Signaling and Prevents Osteoclast Precursor Differentiation, In Vitro and In Mice
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DOI: 10.1002/jbmr.3172
Abstract: The mechanistic target of rapamycin complex 1 (mTORC1) is a critical sensor for bone homeostasis and bone formation; however, the role of mTORC1 in osteoclast development and the underlying mechanisms have not yet been fully… read more here.
Keywords: mtorc1 osteoclast; mtorc1; bone; differentiation vitro ... See more keywords
Altered mTORC1 signalling may contribute to macrophage dysregulation in hidradenitis suppurativa
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DOI: 10.1007/s00011-017-1115-6
Abstract: complexes known as mTORC1 and mTORC2 [5]. mTORC1 is the major regulator of survival, growth, proliferation and motility, in response to mitogens, energy and nutrient levels [6]. Due to its central role in cellular functions,… read more here.
Keywords: dysregulation; may contribute; contribute macrophage; mtorc1 ... See more keywords
Endoplasmic reticulum-localized ECM1b suppresses tumor growth and regulates MYC and MTORC1 through modulating MTORC2 activation in esophageal squamous cell carcinoma.
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DOI: 10.1016/j.canlet.2019.07.005
Abstract: Esophageal squamous cell carcinoma (ESCC) is a deadly disease with dismal 5-year survival. Extracellular matrix protein 1 (ECM1) was identified as one of the most downregulated genes by transcriptomic analysis of normal esophageal/ESCC paired tissue… read more here.
Keywords: cell; endoplasmic reticulum; cell carcinoma; squamous cell ... See more keywords
The amino acid transporter PAT1 regulates mTORC1 in a nutrient-sensitive manner that requires its transport activity.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2018.09.017
Abstract: The proton-coupled amino acid transporter PAT1 has been postulated to regulate the amino acid-stimulated mTORC1 through two different mechanisms, either it activates mTORC1 by sensing and transducing the lysosomal amino acid signal to mTORC1, or… read more here.
Keywords: amino acid; acid transporter; mtorc1; pat1 ... See more keywords
Loss of a Negative Regulator of mTORC1 Induces Aerobic Glycolysis and Altered Fiber Composition in Skeletal Muscle
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DOI: 10.1016/j.celrep.2018.04.058
Abstract: SUMMARY The conserved GATOR1 complex consisting of NPRL2-NPRL3-DEPDC5 inhibits mammalian target of rapamycin complex 1 (mTORC1) in response to amino acid insufficiency. Here, we show that loss of NPRL2 and GATOR1 function in skeletal muscle… read more here.
Keywords: skeletal muscle; altered fiber; muscle; mtorc1 ... See more keywords
Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR.
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DOI: 10.1016/j.celrep.2020.107571
Abstract: Mechanistic target of rapamycin complex 1 (mTORC1) is a master modulator of cellular growth, and its aberrant regulation is recurrently documented within breast cancer. While the small GTPase Rheb1 is the canonical activator of mTORC1,… read more here.
Keywords: rheb1 independent; mutations mtor; mtorc1 activation; mtorc1 ... See more keywords
RORα is critical for mTORC1 activity in T cell-mediated colitis.
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DOI: 10.1016/j.celrep.2021.109682
Abstract: Inflammatory bowel disease (IBD) is multi-factorial chronic intestinal inflammation driven by pathogenic T cells, among which a large portion of patients are resistant to current anti-inflammatory regimes. The mechanisms underlying colitis pathogenicity and drug resistance are… read more here.
Keywords: mediated colitis; cell mediated; ror; mtorc1 ... See more keywords