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   Articles with "mtorc1" as a keyword



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TSC2/Rheb signaling mediates ERK‐dependent regulation of mTORC1 activity in C2C12 myoblasts

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recommendations! Published in 2017 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12195

Abstract: The enhanced rate of protein synthesis in skeletal muscle cells results in a net increase in total protein content that leads to skeletal muscle growth/hypertrophy. The mitogen‐activated protein kinase kinase (MEK)/extracellular signal‐regulated kinase (ERK)‐dependent regulation… read more here.

Keywords: c2c12 myoblasts; mtorc1; activation; erk dependent ... See more keywords

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

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recommendations! Published in 2025 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.70085

Abstract: TELO2‐TTI1‐TTI2 (TTT) and R2TP are multi‐subunit chaperones that cooperate with HSP90 to assemble matured complexes of the PIKK family of kinases, including mTOR complex 1 (mTORC1). WAC, a protein previously implicated in transcription, H2B ubiquitination,… read more here.

Keywords: availability; mtorc1; mtor; glucose glutamine ... See more keywords

Significant impact of mTORC1 and ATF4 pathways in CHO cell recombinant protein production induced by CDK4/6 inhibitor.

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recommendations! Published in 2022 at "Biotechnology and bioengineering"

DOI: 10.1002/bit.28050

Abstract: The CDK4/6 inhibitor has been shown to increase recombinant protein productivity in Chinese hamster ovary cells (CHO). Therefore, we investigated the mechanism that couples cell cycle inhibitor (CCI) treatment with protein productivity utilizing proteomics and… read more here.

Keywords: recombinant protein; phosphorylation; mtorc1; cdk4 inhibitor ... See more keywords

DEP domain–containing mTOR–interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute‐on‐chronic liver injury in alcoholic liver disease

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recommendations! Published in 2018 at "Hepatology"

DOI: 10.1002/hep.29849

Abstract: Alcoholic liver disease (ALD) is characterized by lipid accumulation and liver injury. However, how chronic alcohol consumption causes hepatic lipid accumulation remains elusive. The present study demonstrates that activation of the mechanistic target of rapamycin… read more here.

Keywords: liver; mtorc1; mtor; liver injury ... See more keywords

RNA helicase DEAD‐box protein 5 alleviates nonalcoholic steatohepatitis progression via tethering TSC complex and suppressing mTORC1 signaling

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recommendations! Published in 2022 at "Hepatology"

DOI: 10.1002/hep.32651

Abstract: Background and Aims: Nonalcoholic fatty liver disease and its progressive form, nonalcoholic steatohepatitis (NASH), are rapidly becoming the top causes of hepatocellular carcinoma (HCC). Currently, there are no approved therapies for the treatment of NASH.… read more here.

Keywords: ddx5; mtorc1; dead box; nonalcoholic steatohepatitis ... See more keywords

mTORC1 Inhibits NF‐κB/NFATc1 Signaling and Prevents Osteoclast Precursor Differentiation, In Vitro and In Mice

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recommendations! Published in 2017 at "Journal of Bone and Mineral Research"

DOI: 10.1002/jbmr.3172

Abstract: The mechanistic target of rapamycin complex 1 (mTORC1) is a critical sensor for bone homeostasis and bone formation; however, the role of mTORC1 in osteoclast development and the underlying mechanisms have not yet been fully… read more here.

Keywords: mtorc1 osteoclast; mtorc1; bone; differentiation vitro ... See more keywords

Altered mTORC1 signalling may contribute to macrophage dysregulation in hidradenitis suppurativa

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recommendations! Published in 2018 at "Inflammation Research"

DOI: 10.1007/s00011-017-1115-6

Abstract: complexes known as mTORC1 and mTORC2 [5]. mTORC1 is the major regulator of survival, growth, proliferation and motility, in response to mitogens, energy and nutrient levels [6]. Due to its central role in cellular functions,… read more here.

Keywords: dysregulation; may contribute; contribute macrophage; mtorc1 ... See more keywords

Isothiocyanates induce autophagy and inhibit protein synthesis in primary cells via modulation of AMPK-mTORC1-S6K1 signaling pathway, and protect against mutant huntingtin aggregation

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recommendations! Published in 2024 at "European Journal of Nutrition"

DOI: 10.1007/s00394-024-03539-z

Abstract: Autophagy is a degradation process whose activation underlies beneficial effects of caloric restriction. Isothiocyanates (ITCs) induce autophagy in cancer cells, however, their impact on primary cells remains insufficiently explored, particularly in non-epithelial cells. The aim… read more here.

Keywords: s6k1; ampk; mtorc1; induce autophagy ... See more keywords

Endoplasmic reticulum-localized ECM1b suppresses tumor growth and regulates MYC and MTORC1 through modulating MTORC2 activation in esophageal squamous cell carcinoma.

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recommendations! Published in 2019 at "Cancer letters"

DOI: 10.1016/j.canlet.2019.07.005

Abstract: Esophageal squamous cell carcinoma (ESCC) is a deadly disease with dismal 5-year survival. Extracellular matrix protein 1 (ECM1) was identified as one of the most downregulated genes by transcriptomic analysis of normal esophageal/ESCC paired tissue… read more here.

Keywords: cell; endoplasmic reticulum; cell carcinoma; squamous cell ... See more keywords

The amino acid transporter PAT1 regulates mTORC1 in a nutrient-sensitive manner that requires its transport activity.

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recommendations! Published in 2019 at "Cellular signalling"

DOI: 10.1016/j.cellsig.2018.09.017

Abstract: The proton-coupled amino acid transporter PAT1 has been postulated to regulate the amino acid-stimulated mTORC1 through two different mechanisms, either it activates mTORC1 by sensing and transducing the lysosomal amino acid signal to mTORC1, or… read more here.

Keywords: amino acid; acid transporter; mtorc1; pat1 ... See more keywords

Loss of a Negative Regulator of mTORC1 Induces Aerobic Glycolysis and Altered Fiber Composition in Skeletal Muscle

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recommendations! Published in 2018 at "Cell reports"

DOI: 10.1016/j.celrep.2018.04.058

Abstract: SUMMARY The conserved GATOR1 complex consisting of NPRL2-NPRL3-DEPDC5 inhibits mammalian target of rapamycin complex 1 (mTORC1) in response to amino acid insufficiency. Here, we show that loss of NPRL2 and GATOR1 function in skeletal muscle… read more here.

Keywords: skeletal muscle; altered fiber; muscle; mtorc1 ... See more keywords