Role of FLCN Phosphorylation in Insulin-Mediated mTORC1 Activation and Tumorigenesis.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202206826
Abstract: The amino acid-stimulated Rag GTPase pathway is one of the main pathways that regulate mechanistic target of rapamycin complex 1 (mTORC1) activation and function, but little is known about the effects of growth factors on… read more here.
Keywords: flcn phosphorylation; mediated mtorc1; mtorc1 activation; phosphorylation ... See more keywords
Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107571
Abstract: Mechanistic target of rapamycin complex 1 (mTORC1) is a master modulator of cellular growth, and its aberrant regulation is recurrently documented within breast cancer. While the small GTPase Rheb1 is the canonical activator of mTORC1,… read more here.
Keywords: rheb1 independent; mutations mtor; mtorc1 activation; mtorc1 ... See more keywords
Phosphofructokinases Axis Controls Glucose-Dependent mTORC1 Activation Driven by E2F1
Sign Up to like & getrecommendations! Published in 2019 at "iScience"
DOI: 10.1016/j.isci.2019.09.040
Abstract: Summary Cancer cells rely on mTORC1 activity to coordinate mitogenic signaling with nutrients availability for growth. Based on the metabolic function of E2F1, we hypothesize that glucose catabolism driven by E2F1 could participate on mTORC1… read more here.
Keywords: mtorc1 activity; mtorc1 activation; activation; driven e2f1 ... See more keywords
Electric field-induced suppression of PTEN drives epithelial-to-mesenchymal transition via mTORC1 activation.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2016.11.007
Abstract: BACKGROUND Naturally occurring electric fields (EFs) are an intrinsic property of wounds. Endogenous EFs in skin wounds play critical roles in the dynamic and well-ordered biological process of wound healing. The epithelial-to-mesenchymal transition (EMT) allows… read more here.
Keywords: emt; suppression; mtorc1 activation; transition ... See more keywords
mTORC1 activation contributes to autophagy inhibition via its recruitment to lysosomes and consequent lysosomal dysfunction in cadmium-exposed rat proximal tubular cells.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2020.111231
Abstract: Autophagy dysregulation is implicated in cadmium (Cd)-induced nephrotoxicity. The mammalian target of rapamycin complex 1 (mTORC1) is a negative regulator of autophagy, but its role in Cd-induced autophagy inhibition and possible regulatory mechanisms remains poorly… read more here.
Keywords: rat proximal; autophagy inhibition; inhibition; mtorc1 activation ... See more keywords
Small is beautiful–a glycolytic metabolite signals mTORC1 activation in cancer cell metabolism
Sign Up to like & getrecommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-00371-9
Abstract: Even though the mTOR complex has been known for decades as a nutrient sensor, being thus in focus for drug targeting in metabolic disease and cancer metabolism, it has remained puzzling how it is able… read more here.
Keywords: dhap; metabolism; mtorc1 activation; mtorc1 ... See more keywords
Tangshenning Attenuates High Glucose-Induced Podocyte Injury via Restoring Autophagy Activity through Inhibiting mTORC1 Activation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Diabetes Research"
DOI: 10.1155/2022/1610416
Abstract: Diabetic nephropathy (DN) is a microvascular complication of diabetes mellitus (DM) and the most common cause of death in diabetic patients. DN progression is associated with podocyte damage due to reduced autophagy caused by mTORC1… read more here.
Keywords: glucose induced; induced podocyte; podocyte injury; high glucose ... See more keywords
PKG1α Cysteine-42 Redox State Controls mTORC1 Activation in Pathological Cardiac Hypertrophy
Sign Up to like & getrecommendations! Published in 2020 at "Circulation Research"
DOI: 10.1161/circresaha.119.315714
Abstract: Supplemental Digital Content is available in the text. Rationale: Stimulated PKG1α (protein kinase G-1α) phosphorylates TSC2 (tuberous sclerosis complex 2) at serine 1365, potently suppressing mTORC1 (mechanistic [mammalian] target of rapamycin complex 1) activation by… read more here.
Keywords: activation; hypertrophy; cysteine; mtorc1 activation ... See more keywords
Tuberous sclerosis complex inactivation disrupts melanogenesis via mTORC1 activation
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Investigation"
DOI: 10.1172/jci84262
Abstract: Tuberous sclerosis complex (TSC) is an autosomal dominant tumor-suppressor gene syndrome caused by inactivating mutations in either TSC1 or TSC2, and the TSC protein complex is an essential regulator of mTOR complex 1 (mTORC1). Patients… read more here.
Keywords: tuberous sclerosis; bgr; sclerosis complex; mtorc1 activation ... See more keywords
mTORC1 activation assessed in metastatic sample to predict outcome in patients with metastatic breast cancer treated with everolimus-exemestan: Results from the SAFIRTOR study.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.1024
Abstract: 1024 Background: Using samples from TAMRAD study (Treilleux, Ann Oncol, 2015), we previously reported that p4EBP1, a downstream protein of mTOR, was associated with higher benefit to everolimus (eve). SAFIRTOR study was designed to validate… read more here.
Keywords: safirtor study; p4ebp1; mtorc1 activation; analysis ... See more keywords
Blocking the Farnesyl Pocket of PDEδ Reduces Rheb-Dependent mTORC1 Activation and Survival of Tsc2-Null Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.912688
Abstract: Rheb is a small GTPase member of the Ras superfamily and an activator of mTORC1, a protein complex master regulator of cell metabolism, growth, and proliferation. Rheb/mTORC1 pathway is hyperactivated in proliferative diseases, such as… read more here.
Keywords: mtorc1; pde; rheb dependent; tsc2 null ... See more keywords