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   Articles with "mtorc1 activity" as a keyword



Phosphofructokinases Axis Controls Glucose-Dependent mTORC1 Activation Driven by E2F1

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recommendations! Published in 2019 at "iScience"

DOI: 10.1016/j.isci.2019.09.040

Abstract: Summary Cancer cells rely on mTORC1 activity to coordinate mitogenic signaling with nutrients availability for growth. Based on the metabolic function of E2F1, we hypothesize that glucose catabolism driven by E2F1 could participate on mTORC1… read more here.

Keywords: mtorc1 activity; mtorc1 activation; activation; driven e2f1 ... See more keywords

mTORC1 signaling pathway regulates macrophages in choroidal neovascularization.

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recommendations! Published in 2020 at "Molecular immunology"

DOI: 10.1016/j.molimm.2020.03.002

Abstract: Macrophages are involved in choroidal neovascularization (CNV). The mechanistic target of rapamycin complex 1 (mTORC1) is a central cell regulator, but mTORC1 function in macrophages in CNV is not fully understood. We explored the effect… read more here.

Keywords: cnv lesions; choroidal neovascularization; mtorc1; mtorc1 activity ... See more keywords

High mTORC1 activity drives glycolysis addiction and sensitivity to G6PD inhibition in acute myeloid leukemia cells

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recommendations! Published in 2017 at "Leukemia"

DOI: 10.1038/leu.2017.81

Abstract: Alterations in metabolic activities are cancer hallmarks that offer a wide range of new therapeutic opportunities. Here we decipher the interplay between mTORC1 activity and glucose metabolism in acute myeloid leukemia (AML). We show that… read more here.

Keywords: high mtorc1; mtorc1; mtorc1 activity; aml ... See more keywords

MCOLN/TRPML channels in the regulation of MTORC1 and autophagy

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recommendations! Published in 2024 at "Autophagy"

DOI: 10.1080/15548627.2023.2300922

Abstract: ABSTRACT MCOLN1 and MCOLN3 are two Ca2+ release channels residing in the endolysosomal membrane. They are activated by phosphatidylinositol (PtdIns)-3-phosphate (PtdIns3P) and/or PtdIns(3,5)P2. Their activities are also regulated by lumenal pH, with low pH enhancing… read more here.

Keywords: autophagy mcoln; mtorc1; mtorc1 activity; mcoln trpml ... See more keywords

PP2A-dependent TFEB activation is blocked by PIKfyve-induced mTORC1 activity.

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recommendations! Published in 2022 at "Molecular biology of the cell"

DOI: 10.1091/mbc.e21-06-0309

Abstract: Transcriptional factor EB (TFEB) is a master regulator of genes required for autophagy and lysosomal function. The nuclear localization of TFEB is blocked by the mechanistic target of rapamycin complex 1 (mTORC1)-dependent phosphorylation of TFEB at… read more here.

Keywords: phosphorylation; tfeb; pikfyve; mtorc1 ... See more keywords

Significance of low mTORC1 activity in defining the characteristics of brain tumor stem cells

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recommendations! Published in 2017 at "Neuro-Oncology"

DOI: 10.1093/neuonc/now237

Abstract: Background The significance of mammalian target of rapamycin complex 1 (mTORC1) activity in the maintenance of cancer stem cells (CSCs) remains controversial. Previous findings showed that mTORC1 activation depleted the population of leukemia stem cells… read more here.

Keywords: low mtorc1; stem cells; mtorc1 activity; activity ... See more keywords

DYRK1A interacts with the tuberous sclerosis complex and promotes mTORC1 activity

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recommendations! Published in 2024 at "eLife"

DOI: 10.1101/2023.01.18.524493

Abstract: DYRK1A, a ubiquitously expressed kinase, is linked to the dominant intellectual developmental disorder, microcephaly and Down syndrome in humans. It regulates numerous cellular processes such as cell cycle, vesicle trafficking and microtubule assembly. DYRK1A is… read more here.

Keywords: tuberous sclerosis; interacts tuberous; dyrk1a interacts; dyrk1a ... See more keywords

Abstract Tu0046: Cholesterol-mTOR Nexus: Dissecting the Impact of Hypercholesterolemia in Lysosomal Dysfunction

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recommendations! Published in 2025 at "Arteriosclerosis, Thrombosis, and Vascular Biology"

DOI: 10.1161/atv.45.suppl_1.tu0046

Abstract: Introduction: Atherosclerosis is the primary cause of death globally. During atherosclerosis, cholesterol in arterial walls triggers inflammation, recruiting monocytes and macrophages. These cells show impaired autophagy, creating a hyperinflammatory, proatherogenic state unaddressed by current cholesterol-lowering… read more here.

Keywords: cholesterol; mtorc1; monocyte mtorc1; apoptosis ... See more keywords

GATOR2-dependent mTORC1 activity is a therapeutic vulnerability in FOXO1 fusion–positive rhabdomyosarcoma

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recommendations! Published in 2022 at "JCI Insight"

DOI: 10.1172/jci.insight.162207

Abstract: Oncogenic FOXO1 gene fusions drive a subset of rhabdomyosarcoma (RMS) with poor survival; to date, these cancer drivers are therapeutically intractable. To identify new therapies for this disease, we undertook an isogenic CRISPR-interference screen to… read more here.

Keywords: vulnerability foxo1; mtorc1 activity; mtorc1; fusion positive ... See more keywords

A two-pore channel protein required for regulating mTORC1 activity on starvation

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recommendations! Published in 2020 at "BMC Biology"

DOI: 10.1186/s12915-019-0735-4

Abstract: Background Two-pore channels (TPCs) release Ca 2+ from acidic intracellular stores and are implicated in a number of diseases, but their role in development is unclear. The social amoeba Dictyostelium discoideum proliferates as single cells… read more here.

Keywords: starvation; mtorc1; mtorc1 activity; two pore ... See more keywords

OR29-04 High-fat Diet Decreases mTORC1 Activity In Thyrocytes And Impairs Thyroid Function

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recommendations! Published in 2024 at "Journal of the Endocrine Society"

DOI: 10.1210/jendso/bvae163.2450

Abstract: Abstract C.L. Rossetti: None. C. Pintado: None. R.A. Louzada: None. E. Bernal-Mizrachi: None. J.P. Saar Werneck de Castro: None. Individuals suffering from obesity or insulin resistance (IR) have a higher prevalence of hypothyroidism. However, the… read more here.

Keywords: thyroid function; none; mtorc1 activity; activity ... See more keywords