Phosphofructokinases Axis Controls Glucose-Dependent mTORC1 Activation Driven by E2F1
Sign Up to like & getrecommendations! Published in 2019 at "iScience"
DOI: 10.1016/j.isci.2019.09.040
Abstract: Summary Cancer cells rely on mTORC1 activity to coordinate mitogenic signaling with nutrients availability for growth. Based on the metabolic function of E2F1, we hypothesize that glucose catabolism driven by E2F1 could participate on mTORC1… read more here.
Keywords: mtorc1 activity; mtorc1 activation; activation; driven e2f1 ... See more keywords
mTORC1 signaling pathway regulates macrophages in choroidal neovascularization.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular immunology"
DOI: 10.1016/j.molimm.2020.03.002
Abstract: Macrophages are involved in choroidal neovascularization (CNV). The mechanistic target of rapamycin complex 1 (mTORC1) is a central cell regulator, but mTORC1 function in macrophages in CNV is not fully understood. We explored the effect… read more here.
Keywords: cnv lesions; choroidal neovascularization; mtorc1; mtorc1 activity ... See more keywords
High mTORC1 activity drives glycolysis addiction and sensitivity to G6PD inhibition in acute myeloid leukemia cells
Sign Up to like & getrecommendations! Published in 2017 at "Leukemia"
DOI: 10.1038/leu.2017.81
Abstract: Alterations in metabolic activities are cancer hallmarks that offer a wide range of new therapeutic opportunities. Here we decipher the interplay between mTORC1 activity and glucose metabolism in acute myeloid leukemia (AML). We show that… read more here.
Keywords: high mtorc1; mtorc1; mtorc1 activity; aml ... See more keywords
PP2A-dependent TFEB activation is blocked by PIKfyve-induced mTORC1 activity.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e21-06-0309
Abstract: Transcriptional factor EB (TFEB) is a master regulator of genes required for autophagy and lysosomal function. The nuclear localization of TFEB is blocked by the mechanistic target of rapamycin complex 1 (mTORC1)-dependent phosphorylation of TFEB at… read more here.
Keywords: phosphorylation; tfeb; pikfyve; mtorc1 ... See more keywords
Significance of low mTORC1 activity in defining the characteristics of brain tumor stem cells
Sign Up to like & getrecommendations! Published in 2017 at "Neuro-Oncology"
DOI: 10.1093/neuonc/now237
Abstract: Background The significance of mammalian target of rapamycin complex 1 (mTORC1) activity in the maintenance of cancer stem cells (CSCs) remains controversial. Previous findings showed that mTORC1 activation depleted the population of leukemia stem cells… read more here.
Keywords: low mtorc1; stem cells; mtorc1 activity; activity ... See more keywords
GATOR2-dependent mTORC1 activity is a therapeutic vulnerability in FOXO1 fusion–positive rhabdomyosarcoma
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.162207
Abstract: Oncogenic FOXO1 gene fusions drive a subset of rhabdomyosarcoma (RMS) with poor survival; to date, these cancer drivers are therapeutically intractable. To identify new therapies for this disease, we undertook an isogenic CRISPR-interference screen to… read more here.
Keywords: vulnerability foxo1; mtorc1 activity; mtorc1; fusion positive ... See more keywords
A two-pore channel protein required for regulating mTORC1 activity on starvation
Sign Up to like & getrecommendations! Published in 2020 at "BMC Biology"
DOI: 10.1186/s12915-019-0735-4
Abstract: Background Two-pore channels (TPCs) release Ca 2+ from acidic intracellular stores and are implicated in a number of diseases, but their role in development is unclear. The social amoeba Dictyostelium discoideum proliferates as single cells… read more here.
Keywords: starvation; mtorc1; mtorc1 activity; two pore ... See more keywords
Pharmacological inhibition of mTORC1 activity protects against inflammation-induced apoptosis of nucleus pulposus cells
Sign Up to like & getrecommendations! Published in 2021 at "Brazilian Journal of Medical and Biological Research"
DOI: 10.1590/1414-431x202010185
Abstract: Lumbar disc herniation is a common disease characterized by the degeneration of intervertebral discs (IVDs), accompanied by imbalance of metabolic and inflammatory homeostasis. Current studies establish that IVD degeneration is induced by increased apoptosis of… read more here.
Keywords: apoptosis nucleus; apoptosis; nucleus pulposus; mtorc1 ... See more keywords
mTORC1 Is a Local, Postsynaptic Voltage Sensor Regulated by Positive and Negative Feedback Pathways
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2017.00152
Abstract: The mammalian/mechanistic target of rapamycin complex 1 (mTORC1) serves as a regulator of mRNA translation. Recent studies suggest that mTORC1 may also serve as a local, voltage sensor in the postsynaptic region of neurons. Considering… read more here.
Keywords: voltage; mtorc1; mtorc1 activity; activity ... See more keywords