mTORC1 inhibition with rapamycin exacerbates adipose tissue inflammation in obese mice and dissociates macrophage phenotype from function.
Sign Up to like & getrecommendations! Published in 2017 at "Immunobiology"
DOI: 10.1016/j.imbio.2016.09.014
Abstract: Genetic- and diet-induced obesity and insulin resistance are associated with an increase in mechanistic target of rapamycin complex (mTORC) 1 activity in adipose tissue. We investigated herein the effects of pharmacological mTORC1 inhibition in the… read more here.
Keywords: mtorc1 inhibition; tissue; adipose tissue; rapamycin ... See more keywords
Ribophagy: new receptor discovered
Sign Up to like & getrecommendations! Published in 2018 at "Cell Research"
DOI: 10.1038/s41422-018-0054-2
Abstract: Autophagy can promote the lysosomal degradation of specific cytoplasmic substrates recognized by cargo receptors. A recent study published in Science identifies a ribosome receptor required for the autophagic targeting of ribosomes to the lysosome. Autophagy… read more here.
Keywords: mtorc1 inhibition; znhit3; inhibition; autophagy ... See more keywords
Cardamonin protects against adverse cardiac remodeling through mTORC1 inhibition in mice with myocardial infarction.
Sign Up to like & getrecommendations! Published in 2018 at "Die Pharmazie"
DOI: 10.1691/ph.2018.8600
Abstract: The mTORC1-dependent signaling pathway is mainly involved in the adverse left ventricular remodeling (ALVR) process after myocardial infarction (MI). However, whether mTORC1 inhibition by cardamonin attenuates ALVR after MI is still not reported. Twenty mice… read more here.
Keywords: cardamonin; myocardial infarction; mtorc1 inhibition; mice ... See more keywords
mTORC1 Inhibition Protects Human Regulatory T Cells From Granzyme-B-Induced Apoptosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.899975
Abstract: Regulatory T cells (Tregs) have shown great promise as a means of cellular therapy in a multitude of allo- and auto-immune diseases—due in part to their immunosuppressive potency. Nevertheless, the clinical efficacy of human Tregs… read more here.
Keywords: human treg; mtorc1 inhibition; apoptosis; regulatory cells ... See more keywords