Dual inhibition of mTORC1 and mTORC2 perturbs cytoskeletal organization and impairs endothelial cell elongation.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.02.080
Abstract: Elongation of endothelial cells is an important process in vascular formation and is expected to be a therapeutic target for inhibiting tumor angiogenesis. We have previously demonstrated that inhibition of mTORC1 and mTORC2 impaired endothelial… read more here.
Keywords: cell; endothelial cell; cell elongation; mtorc1 mtorc2 ... See more keywords
Diverse signaling mechanisms of mTOR complexes: mTORC1 and mTORC2 in forming a formidable relationship.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in biological regulation"
DOI: 10.1016/j.jbior.2019.03.003
Abstract: Activation of Mechanistic target of rapamycin (mTOR) signaling plays a crucial role in tumorigenesis of numerous malignancies including glioblastoma (GB). The Canonical PI3K/Akt/mTOR signaling cascade is commonly upregulated due to loss of the tumor suppressorm… read more here.
Keywords: complexes mtorc1; mtor; activity; mtorc1 mtorc2 ... See more keywords
mTORC1 and mTORC2 in cancer and the tumor microenvironment
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.363
Abstract: The mammalian target of rapamycin (mTOR) is a crucial signaling node that integrates environmental cues to regulate cell survival, proliferation and metabolism, and is often deregulated in human cancer. mTOR kinase acts in two functionally… read more here.
Keywords: mtorc2 cancer; mtor; mtorc1 mtorc2; cancer ... See more keywords
mTOR Inhibition for Transplantation: More May Not Be Better.
Sign Up to like & getrecommendations! Published in 2017 at "Transplantation"
DOI: 10.1097/tp.0000000000001946
Abstract: T mammalian target of rapamycin (mTOR), a serinethreonine kinase, plays an important role in regulation of extensive cellular activities in multiple systems, including the immune system. It mediates its effects by forming 2 distinct complexes,… read more here.
Keywords: inhibition; transplantation; mtor; mtorc1 mtorc2 ... See more keywords
Dissecting the biology of mTORC1 beyond rapamycin
Sign Up to like & getrecommendations! Published in 2021 at "Science Signaling"
DOI: 10.1126/scisignal.abe0161
Abstract: Description RapaLink1 enables differentiation between functions mediated by the closely related mTORC1 and mTORC2. A tale of two complexes The kinase mTOR is a component of two multiprotein complexes, mTORC1 and mTORC2, which have distinct… read more here.
Keywords: rapamycin; biology; mtorc1 mtorc2; activity ... See more keywords
Epstein-Barr Virus LMP1-Activated mTORC1 and mTORC2 Coordinately Promote Nasopharyngeal Cancer Stem Cell Properties
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.01941-21
Abstract: LMP1 endows NPC to gain cancer stem cell characteristics through activating mTORC1 and mTORC2 pathways. The different mTOR pathways are responsible for distinct tumorigenic features. ABSTRACT Epstein-Barr virus (EBV) is associated with several malignant diseases,… read more here.
Keywords: mtorc1 mtorc2; stem cell; cancer stem;
Regulation and metabolic functions of mTORC1 and mTORC2.
Sign Up to like & getrecommendations! Published in 2021 at "Physiological reviews"
DOI: 10.1152/physrev.00026.2020
Abstract: Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and proliferation. The uptake of nutrients from the environment and their intracellular metabolism is a highly controlled process that involves crosstalk between growth signaling… read more here.
Keywords: metabolism; functions mtorc1; mtor; regulation metabolic ... See more keywords
Rapalogs Target the Endothelium to Set the Stage for Acute Lung Injury
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Respiratory Cell and Molecular Biology"
DOI: 10.1165/rcmb.2021-0250ed
Abstract: Cellular signaling controlled by the serine/threonine kinase mTOR regulates, via the two complexes mTORC1 and mTORC2, fundamental cell functions such as organismal growth, proliferation, autophagy, aging, survival, and metabolism (1). It is therefore not surprising… read more here.
Keywords: mtor; lung; mtori; mtorc1 mtorc2 ... See more keywords
PEBP4 Directs the Malignant Behavior of Hepatocellular Carcinoma Cells via Regulating mTORC1 and mTORC2
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23158798
Abstract: Phosphatidylethanolamine binding protein 4 (PEBP4) is an understudied multifunctional small protein. Previous studies have shown that the expression of PEBP4 is increased in many cancer specimens, which correlates to cancer progression. The present study explored… read more here.
Keywords: mtorc1 mtorc2; hepatocellular carcinoma; pebp4; carcinoma cells ... See more keywords