Geraniol ameliorates diabetic nephropathy via interference with miRNA-21/PTEN/Akt/mTORC1 pathway in rats
Sign Up to like & getrecommendations! Published in 2020 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-020-01944-9
Abstract: Deregulated activity of protein kinase B/mammalian target of rapamycin complex-1 (Akt/mTORC1) incites crucial pathological characteristics of diabetic nephropathy. The acyclic monoterpene geraniol has been recently reported to possess antidiabetic effects; however, its potential renoprotective effect… read more here.
Keywords: mtorc1 pathway; pten akt; diabetic nephropathy; akt mtorc1 ... See more keywords
NCAPD2 inhibits autophagy by regulating Ca2+/CAMKK2/AMPK/mTORC1 pathway and PARP-1/SIRT1 axis to promote colorectal cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.06.029
Abstract: Non-SMC condensin I complex subunit D2 (NCAPD2) is one of the three non-SMC subunits in condensin I. Previous studies have shown that NCAPD2 plays an important role in the chromosome condensation and segregation. However, its… read more here.
Keywords: ncapd2 inhibits; mtorc1 pathway; ampk mtorc1; colorectal cancer ... See more keywords
Sestrin2 Negatively Regulates Casein Synthesis through the SH3BP4-mTORC1 Pathway in Response to AA Depletion or Supplementation in Cow Mammary Epithelial Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b00716
Abstract: Sestrin2 (SESN2) negatively regulates the mammalian target of rapamycin complex 1 (mTORC1) pathway and casein synthesis in response to amino acid (AA) depletion in cow mammary epithelial cells (CMECs); however, the underlying mechanism is unclear.… read more here.
Keywords: sh3bp4; mtorc1 pathway; negatively regulates; negatively regulated ... See more keywords
Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction
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DOI: 10.1038/s41467-017-00785-0
Abstract: Leucyl-tRNA synthetase (LRS) is known to function as leucine sensor in the mammalian target of rapamycin complex 1 (mTORC1) pathway. However, the pathophysiological significance of its activity is not well understood. Here, we demonstrate that the… read more here.
Keywords: mtorc1 pathway; mtorc1; leucyl trna; trna synthetase ... See more keywords
Quantitative genetic screening reveals a Ragulator-FLCN feedback loop that regulates the mTORC1 pathway
Sign Up to like & getrecommendations! Published in 2020 at "Science Signaling"
DOI: 10.1126/scisignal.aba5665
Abstract: A genetic screen in haploid human cells reveals context-specific regulators of the mTORC1 pathway. Perturb and observe screening in haploid cells Yeast have been a powerful model organism for genetic screens because they can easily… read more here.
Keywords: lamtor4; mtorc1 pathway; genetic screens; haploid ... See more keywords
Abstract B092: Molecular aberrations of the PI3K-AKT-mTORC1/C2 pathway in ovarian cancers: a strategy for targeted therapy
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-17-b092
Abstract: Background: Ovarian cancer is the most lethal gynecologic cancer worldwide since most patients are diagnosed at an advanced stage of the disease. Genetic alterations of the PI3K-AKT-mTORC1/C2 pathway in ovarian cancer (OC) are characteristically abundant… read more here.
Keywords: inhibitor; mtorc1 pathway; pi3k akt; cancer ... See more keywords
Alcohol, Resistance Exercise, and mTOR Pathway Signaling: An Evidence-Based Narrative Review
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom13010002
Abstract: Skeletal muscle mass is determined by the balance between muscle protein synthesis (MPS) and degradation. Several intracellular signaling pathways control this balance, including mammalian/mechanistic target of rapamycin (mTOR) complex 1 (C1). Activation of this pathway… read more here.
Keywords: pathway signaling; evidence; alcohol; exercise ... See more keywords