CD146 Regulates Growth Factor-Induced mTORC2 Activity Independent of the PI3K and mTORC1 Pathways.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.09.047
Abstract: The mechanistic target of rapamycin complex 2 (mTORC2) coordinates cell proliferation, survival, and metabolism with environmental inputs, yet how extracellular stimuli such as growth factors (GFs) activate mTORC2 remains enigmatic. Here we demonstrate that in… read more here.
Keywords: mtorc2 activity; cd146; mtorc1 pathways; pi3k mtorc1 ... See more keywords
P1293 Novel mutations in SASH3 cause very early onset IBD by impairing the NF-kB and mTORC1 pathways
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjae190.1467
Abstract: Human SAM and SH3 domain-containing 3 (SASH3) variants globally affect TCR signaling including its downstream mTORC1 and NF-kB signaling. These 3 pathys play great roles in the pathogenesis of very early-onset inflammatory bowel diseases (VEO-IBD).… read more here.
Keywords: ibd; mtorc1 pathways; protein; figure ... See more keywords