Selective inhibition of mTORC1/2 or PI3K/mTORC1/2 signaling does not prevent or modify epilepsy in the intrahippocampal kainate mouse model
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DOI: 10.1016/j.neuropharm.2019.107817
Abstract: Dysregulation of the PI3K/Akt/mTOR pathway has been implicated in several brain disorders, including epilepsy. Rapamycin and similar compounds inhibit mTOR. complex 1 and have been reported to decrease seizures, delay seizure development, or prevent epileptogenesis… read more here.
Keywords: epilepsy; pi3k; mtorc1 pi3k; mtorc1 ... See more keywords