Remyelination in neuromyelitis optica spectrum disorder is promoted by edaravone through mTORC1 signaling activation
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24271
Abstract: Neuromyelitis optica spectrum disorder (NMOSD) is a severe inflammatory autoimmune disease of the central nervous system that is manifested as secondary myelin loss. Oligodendrocyte progenitor cells (OPCs) are the principal source of myelinating oligodendrocytes (OLs)… read more here.
Keywords: neuromyelitis optica; remyelination; mtorc1 signaling; optica spectrum ... See more keywords
mTORC1 signaling activation increases intestinal stem cell activity and promotes epithelial cell proliferation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28542
Abstract: The crypt‐villus axis of the intestine undergoes a continuous renewal process that is driven by intestinal stem cells (ISCs). However, the homeostasis is disturbed under constant exposure to high ambient temperatures, and the precise mechanism… read more here.
Keywords: mtorc1 signaling; exposure; stem; cell ... See more keywords
PAQR3 augments amino acid deprivation-induced autophagy by inhibiting mTORC1 signaling.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2017.02.017
Abstract: Amino acids are the key activators of the mTOR complex 1 (mTORC1, mainly composed of mTOR, Raptor and mLST8) required for cell growth and proliferation. On the other hand, deprivation of amino acids induces autophagy… read more here.
Keywords: acid deprivation; paqr3; amino acid; mtorc1 signaling ... See more keywords
Curcumin represses mTORC1 signaling in Caco-2 cells by a two-sided mechanism involving the loss of IRS-1 and activation of AMPK.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2020.109842
Abstract: The mechanistic target of rapamycin complex 1 (mTORC1) is a central modulator of inflammation and tumorigenesis in the gastrointestinal tract. Growth factors upregulate mTORC1 via the PI3K/AKT and/or Ras/MAPK signal pathways. Curcumin (CUR), a polyphenol… read more here.
Keywords: caco cells; mtorc1 signaling; mechanism; loss irs ... See more keywords
Metabolic compensation activates pro-survival mTORC1 signaling upon 3-phosphoglycerate dehydrogenase inhibition in osteosarcoma.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2020.108678
Abstract: Osteosarcoma is the most common pediatric and adult primary malignant bone cancer. Curative regimens target the folate pathway, downstream of serine metabolism, with high-dose methotrexate. Here, the rate-limiting enzyme in the biosynthesis of serine from… read more here.
Keywords: pro survival; phosphoglycerate dehydrogenase; mtorc1 signaling; inhibition ... See more keywords
Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex.
Sign Up to like & getrecommendations! Published in 2017 at "Cell metabolism"
DOI: 10.1016/j.cmet.2016.12.009
Abstract: Metformin is the most widely prescribed drug for the treatment of type 2 diabetes. However, knowledge of the full effects of metformin on biochemical pathways and processes in its primary target tissue, the liver, is limited. One… read more here.
Keywords: hepatic mtorc1; tsc complex; mtorc1 signaling; metformin ... See more keywords
Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling.
Sign Up to like & getrecommendations! Published in 2019 at "Cell metabolism"
DOI: 10.1016/j.cmet.2019.03.005
Abstract: The mechanistic target of rapamycin complex (mTORC1) is a signaling hub on the lysosome surface, responding to lysosomal amino acids. Although arginine is metabolically important, the physiological arginine sensor that activates mTOR remains unclear. Here,… read more here.
Keywords: six family; tm4sf5; mtorc1 signaling; transmembrane six ... See more keywords
Venlafaxine protects against chronic stress-related behaviors in mice by activating the mTORC1 signaling cascade.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2020.07.096
Abstract: BACKGROUND Recent studies have suggested the role of mammalian target of rapamycin complex 1 (mTORC1) in the pathophysiology of depression. Although venlafaxine was thought to be a serotonin and norepinephrine reuptake inhibitor (SNRI), its pharmacological… read more here.
Keywords: mtorc1 signaling; venlafaxine; mtorc1 system; mtorc1 ... See more keywords
The anticancer effects of curcumin via targeting the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacological research"
DOI: 10.1016/j.phrs.2020.104798
Abstract: The mammalian target of rapamycin (mTOR) is a protein kinase that has been considered as a key regulator of a large number of cellular processes, including cell growth, proliferation, differentiation, survival, and motility. Overactivation of… read more here.
Keywords: mtorc1 signaling; kinase; target; mtorc1 ... See more keywords
A low-dose combination of ketamine and guanosine counteracts corticosterone-induced depressive-like behavior and hippocampal synaptic impairments via mTORC1 signaling
Sign Up to like & getrecommendations! Published in 2021 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2021.110371
Abstract: Ketamine exhibits rapid and sustained antidepressant responses, but its repeated use may cause adverse effects. Augmentation strategies have been postulated to be useful for the management/reduction of ketamine's dose and its adverse effects. Based on… read more here.
Keywords: mtorc1 signaling; guanosine; ketamine; depressive like ... See more keywords
mTORC1 Signaling is a Critical Regulator of Postnatal Tendon Development
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DOI: 10.1038/s41598-017-17384-0
Abstract: Tendons transmit contractile forces between musculoskeletal tissues. Whereas the biomechanical properties of tendons have been studied extensively, the molecular mechanisms regulating postnatal tendon development are not well understood. Here we examine the role of mTORC1… read more here.
Keywords: tendon; tendon development; mtorc1 signaling; postnatal tendon ... See more keywords