Altered mTORC1 signalling may contribute to macrophage dysregulation in hidradenitis suppurativa
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DOI: 10.1007/s00011-017-1115-6
Abstract: complexes known as mTORC1 and mTORC2 [5]. mTORC1 is the major regulator of survival, growth, proliferation and motility, in response to mitogens, energy and nutrient levels [6]. Due to its central role in cellular functions,… read more here.
Keywords: dysregulation; may contribute; contribute macrophage; mtorc1 ... See more keywords
KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1
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DOI: 10.1038/nature21423
Abstract: The mechanistic target of rapamycin complex 1 (mTORC1) is a central regulator of cell growth that responds to diverse environmental signals and is deregulated in many human diseases, including cancer and epilepsy. Amino acids are… read more here.
Keywords: kicstor; kicstor recruits; mtorc1 signalling; rag gtpases ... See more keywords
Chloroquine and bafilomycin A mimic lysosomal storage disorders and impair mTORC1 signalling
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DOI: 10.1042/bsr20200905
Abstract: Abstract Autophagy is dependent upon lysosomes, which fuse with the autophagosome to complete the autophagic process and whose acidic interior permits the activity of their intraluminal degradative enzymes. Chloroquine (CQ) and bafilomycin A1 (BafA) each… read more here.
Keywords: chloroquine bafilomycin; lysosomal storage; storage disorders; mtorc1 signalling ... See more keywords
Histone H3K27 demethylase KDM6A is an epigenetic gatekeeper of mTORC1 signalling in cancer
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DOI: 10.1136/gutjnl-2021-325405
Abstract: Objective Large-scale genome sequencing efforts of human tumours identified epigenetic modifiers as one of the most frequently mutated gene class in human cancer. However, how these mutations drive tumour development and tumour progression are largely… read more here.
Keywords: kdm6a deficient; demethylase kdm6a; mtorc1; cancer ... See more keywords
Cancer Cell-Derived PDGFB Stimulates mTORC1 Activation in Renal Carcinoma
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DOI: 10.3390/ijms24076447
Abstract: Clear cell renal cell carcinoma (ccRCC) is a hypervascular tumor that is characterized by bi-allelic inactivation of the VHL tumor suppressor gene and mTOR signalling pathway hyperactivation. The pro-angiogenic factor PDGFB, a transcriptional target of… read more here.
Keywords: cell; ccrcc; ccrcc cells; mtorc1 signalling ... See more keywords