CD146 Regulates Growth Factor-Induced mTORC2 Activity Independent of the PI3K and mTORC1 Pathways.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.09.047
Abstract: The mechanistic target of rapamycin complex 2 (mTORC2) coordinates cell proliferation, survival, and metabolism with environmental inputs, yet how extracellular stimuli such as growth factors (GFs) activate mTORC2 remains enigmatic. Here we demonstrate that in… read more here.
Keywords: mtorc2 activity; cd146; mtorc1 pathways; pi3k mtorc1 ... See more keywords
M2 polarization of macrophages by Oncostatin M in hypoxic tumor microenvironment is mediated by mTORC2 and promotes tumor growth and metastasis.
Sign Up to like & getrecommendations! Published in 2018 at "Cytokine"
DOI: 10.1016/j.cyto.2018.03.032
Abstract: Oncostatin M (OSM), an inflammatory cytokine belonging to the interleukin-6 (IL-6) superfamily, plays a vital role in multitude of physiological and pathological processes. Its role in breast tumor progression and metastasis to distant organs is… read more here.
Keywords: tumor; distant organs; polarization macrophages; polarization ... See more keywords
Inhibition of RhoA and mTORC2/Rictor by Fingolimod (FTY720) induces p21-activated kinase 1, PAK-1 and amplifies podosomes in mouse peritoneal macrophages.
Sign Up to like & getrecommendations! Published in 2018 at "Immunobiology"
DOI: 10.1016/j.imbio.2018.07.009
Abstract: Macrophage functions in the immune response depend on their ability to infiltrate tissues and organs. The penetration between and within the tissues requires degradation of extracellular matrix (ECM), a function performed by the specialized, endopeptidase-… read more here.
Keywords: p21 activated; activated kinase; podosomes mouse; kinase pak ... See more keywords
HIV‐1 Nef‐POTEE; A novel interaction modulates macrophage dissemination via mTORC2 signaling pathway
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.10.068
Abstract: Aims: Human immunodeficiency virus −1 [HIV‐1] Nef, localizes in different cellular compartments and modulates several cellular pathways. Nef promotes virus pathogenicity through alteration in cell surface receptor expression, apoptosis, protein trafficking etc. Nef regulates viral… read more here.
Keywords: cell; potee; nef potee; interaction ... See more keywords
Rictor/mTORC2 deficiency enhances keratinocyte stress tolerance via mitohormesis
Sign Up to like & getrecommendations! Published in 2017 at "Cell Death and Differentiation"
DOI: 10.1038/cdd.2017.8
Abstract: How metabolic pathways required for epidermal tissue growth and remodeling influence the ability of keratinocytes to survive stressful conditions is still largely unknown. The mechanistic target of rapamycin complex 2 (mTORC2) regulates growth and metabolism… read more here.
Keywords: rictor; via mitohormesis; stress tolerance; deficiency ... See more keywords
mTORC1 and mTORC2 in cancer and the tumor microenvironment
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.363
Abstract: The mammalian target of rapamycin (mTOR) is a crucial signaling node that integrates environmental cues to regulate cell survival, proliferation and metabolism, and is often deregulated in human cancer. mTOR kinase acts in two functionally… read more here.
Keywords: mtorc2 cancer; mtor; mtorc1 mtorc2; cancer ... See more keywords
TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-17802-4
Abstract: Transmembrane B cell lymphoma 2-associated X protein inhibitor motif-containing (TMBIM) 6, a Ca2+ channel-like protein, is highly up-regulated in several cancer types. Here, we show that TMBIM6 is closely associated with survival in patients with… read more here.
Keywords: tmbim6; akt activation; cancer; progression ... See more keywords
Down-regulation of placental Cdc42 and Rac1 links mTORC2 inhibition to decreased trophoblast amino acid transport in human intrauterine growth restriction.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical science"
DOI: 10.1042/cs20190794
Abstract: Intrauterine growth restriction (IUGR) increases the risk for perinatal complications and metabolic and cardiovascular disease later in life. The syncytiotrophoblast (ST) is the transporting epithelium of the human placenta and decreased expression of amino acid… read more here.
Keywords: mtorc2; amino acid; cdc42 rac1; rac1 ... See more keywords
Ras-mediated activation of mTORC2 promotes breast epithelial cell migration and invasion
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e22-06-0236
Abstract: We previously identified the mechanistic target of rapamycin complex 2 (mTORC2) as an effector of Ras for the control of directed cell migration in Dictyostelium. Recently, the Ras-mediated regulation of mTORC2 was found to be… read more here.
Keywords: cell; mtorc2; breast cancer; migration ... See more keywords
mTOR Inhibition for Transplantation: More May Not Be Better.
Sign Up to like & getrecommendations! Published in 2017 at "Transplantation"
DOI: 10.1097/tp.0000000000001946
Abstract: T mammalian target of rapamycin (mTOR), a serinethreonine kinase, plays an important role in regulation of extensive cellular activities in multiple systems, including the immune system. It mediates its effects by forming 2 distinct complexes,… read more here.
Keywords: inhibition; transplantation; mtor; mtorc1 mtorc2 ... See more keywords
mTOR signaling in renal ion transport
Sign Up to like & getrecommendations! Published in 2023 at "Acta Physiologica"
DOI: 10.1111/apha.13960
Abstract: The mammalian target of rapamycin (mTOR) signaling pathway is crucial in maintaining cell growth and metabolism. The mTOR protein kinase constitutes the catalytic subunit of two multimeric protein complexes called mTOR complex 1 (mTORC1) and… read more here.
Keywords: mtorc2; role; kidney; mtorc1 ... See more keywords