Rapalogs Target the Endothelium to Set the Stage for Acute Lung Injury
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Respiratory Cell and Molecular Biology"
DOI: 10.1165/rcmb.2021-0250ed
Abstract: Cellular signaling controlled by the serine/threonine kinase mTOR regulates, via the two complexes mTORC1 and mTORC2, fundamental cell functions such as organismal growth, proliferation, autophagy, aging, survival, and metabolism (1). It is therefore not surprising… read more here.
Keywords: mtor; lung; mtori; mtorc1 mtorc2 ... See more keywords
Experience using mTOR inhibitors for subependymal giant cell astrocytoma in tuberous sclerosis complex at a single facility
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DOI: 10.1186/s12883-021-02160-5
Abstract: Background Subependymal giant cell astrocytoma (SEGA) is occasionally seen in tuberous sclerosis complex (TSC). Two main options are currently available for treating SEGA: surgical resection or pharmacotherapy using mammalian target of rapamycin inhibitors (mTORi). We… read more here.
Keywords: giant cell; facility; cell astrocytoma; group ... See more keywords