The multistate tuberculosis pharmacometric model: a semi-mechanistic pharmacokinetic-pharmacodynamic model for studying drug effects in an acute tuberculosis mouse model
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmacokinetics and Pharmacodynamics"
DOI: 10.1007/s10928-017-9508-2
Abstract: The Multistate Tuberculosis Pharmacometric (MTP) model, a pharmacokinetic-pharmacodynamic disease model, has been used to describe the effects of rifampicin on Mycobacterium tuberculosis (M. tuberculosis) in vitro. The aim of this work was to investigate if… read more here.
Keywords: tuberculosis mouse; mtp model; model; tuberculosis ... See more keywords
Direct and flexible marginal inference for semicontinuous data
Sign Up to like & getrecommendations! Published in 2017 at "Statistical Methods in Medical Research"
DOI: 10.1177/0962280215602290
Abstract: The marginalized two-part (MTP) model for semicontinuous data proposed by Smith et al. provides direct inference for the effect of covariates on the marginal mean of positively continuous data with zeros. This brief note addresses… read more here.
Keywords: semicontinuous data; flexible marginal; direct flexible; mtp model ... See more keywords