Mutant p53 oncogenic functions in cancer stem cells are regulated by WIP through YAP/TAZ
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.518
Abstract: Wild-type p53 (wtp53) is described as a tumour suppressor gene; mutations in this gene occur in many human cancers and promote oncogenic capacity. Here, we establish that the oncogenic activity of mutant p53 (mtp53) is… read more here.
Keywords: cancer stem; mtp53; mutant p53; yap taz ... See more keywords
Abstract 6186: Patient-derived tumor organoids with p53 mutations, and not wild-type p53, demonstrate synergistic sensitivity to treatment with temozolomide in combination with talazoparib PARP inhibitor
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6186
Abstract: Mutations in the TP53 gene can be found in more than 50% of tumors. We recently showed in 2D breast cancer cell lines that mutant p53 (mtp53) proteins tightly associate with replicating DNA, chromatin and… read more here.
Keywords: mtp53; talazoparib; combination; p53 ... See more keywords
Contemplations on MDMX (MDM4) driving triple negative breast cancer circulating tumor cells and metastasis
Sign Up to like & getrecommendations! Published in 2019 at "Oncotarget"
DOI: 10.18632/oncotarget.27134
Abstract: MDMX (MDM4) is emerging as an important breast cancer (BC) biomarker, and oncoprotein, that can be targeted in combination with its well-known family member MDM2. While MDM2 has previously been implicated in driving BC metastasis,… read more here.
Keywords: metastasis; mtp53; mdmx; breast cancer ... See more keywords
Frame-shift mediated reduction of gain-of-function p53 R273H and deletion of the R273H C-terminus in breast cancer cells result in replication-stress sensitivity
Sign Up to like & getrecommendations! Published in 2021 at "Oncotarget"
DOI: 10.18632/oncotarget.27975
Abstract: We recently documented that gain-of-function (GOF) mutant p53 (mtp53) R273H in triple negative breast cancer (TNBC) cells interacts with replicating DNA and PARP1. The missense R273H GOF mtp53 has a mutated central DNA binding domain… read more here.
Keywords: mtp53 r273h; r273h; mtp53; p53 ... See more keywords
LncRNA H19 Promotes Lung Adenocarcinoma Progression via Binding to Mutant p53 R175H
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14184486
Abstract: Simple Summary This research explored the association and interaction between lncRNA H19 and mutant p53 (R175H) in lung adenocarcinoma development and progression. H19 over-expression may induce the elevated expression of mtp53 and interact with mtp53,… read more here.
Keywords: mtp53; expression; p53; h19 ... See more keywords