Frame-shift mediated reduction of gain-of-function p53 R273H and deletion of the R273H C-terminus in breast cancer cells result in replication-stress sensitivity
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DOI: 10.18632/oncotarget.27975
Abstract: We recently documented that gain-of-function (GOF) mutant p53 (mtp53) R273H in triple negative breast cancer (TNBC) cells interacts with replicating DNA and PARP1. The missense R273H GOF mtp53 has a mutated central DNA binding domain… read more here.
Keywords: mtp53 r273h; r273h; mtp53; p53 ... See more keywords