The N-terminus of MTRR plays a role in MTR reactivation cycle beyond electron transfer.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103836
Abstract: In eucaryotic cells, methionine synthase reductase (MSR/MTRR) is capable of dominating the folate-homocysteine metabolism as an irreplaceable partner in electron transfer for regeneration of methionine synthase. The N-terminus of MTRR containing a conserved domain of… read more here.
Keywords: mtrr; electron transfer; terminus; terminus mtrr ... See more keywords
Associations of homocysteine status and homocysteine metabolism enzyme polymorphisms with hypertension and dyslipidemia in a Chinese hypertensive population
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Experimental Hypertension"
DOI: 10.1080/10641963.2019.1571599
Abstract: ABSTRACT Background: Hypertension (HTN), dyslipidemia and hyperhomocysteinemia (HHcy) are risk factors for cardiovascular disease (CVD). Methods: Hypertensive Chinese subjects (n = 228) were enrolled. MTHFR C667T, MTHFR A1298C, MTR A2756G, and MTRR A66G genotypes were… read more here.
Keywords: hcy; hypertension; dyslipidemia; mtrr ... See more keywords
Association analysis of MTHFR (rs1801133 and rs1801131) and MTRR (rs1801394) gene polymorphisms towards the development of hypertension in the Bai population from Yunnan, China.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical and experimental hypertension"
DOI: 10.1080/10641963.2023.2206066
Abstract: OBJECTIVE Hypertension is one of the leading causes of human death and disability. MTHFR and MTRR regulate folate metabolism and are closely linked to hypertension, although the relationship is inconsistent among different ethnic groups. The… read more here.
Keywords: hypertension; mthfr c677t; mtrr; mthfr ... See more keywords
Variants c.677 C>T, c.1298 A>C in MTHFR, and c.66 A>G in MTRR Affect the Occurrence of Recurrent Pregnancy Loss in Chinese Women
Sign Up to like & getrecommendations! Published in 2020 at "Genetic Testing and Molecular Biomarkers"
DOI: 10.1089/gtmb.2020.0106
Abstract: Objective: Although genetic variants of key enzymes in the folic acid-methionine metabolic circulation, including methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) were thought to be related to the risk of recurrent pregnancy loss (RPL),… read more here.
Keywords: mtrr 66a; chinese women; rpl; mtrr ... See more keywords
MTRR 66 and SHMT1 1420 Variants Are Associated with Optic Disc Edema During 30-d Strict Head-down Tilt Bed Rest and CO2 Exposure (P24-036-19).
Sign Up to like & getrecommendations! Published in 2019 at "Current developments in nutrition"
DOI: 10.1093/cdn/nzz044.p24-036-19
Abstract: Objectives Some astronauts returning from missions to the International Space Station (ISS) have developed ophthalmic structural changes, including optic disc edema. Incidence of optic disc edema among astronauts has been linked to one-carbon pathway genetic… read more here.
Keywords: bed rest; optic disc; mtrr; disc edema ... See more keywords
A Polymorphism in the MTRR Gene Is Associated with Early Childhood Caries and Underweight
Sign Up to like & getrecommendations! Published in 2017 at "Caries Research"
DOI: 10.1159/000451037
Abstract: Polymorphisms in genes encoding the enzymes involved in the metabolism of homocysteine, such as methionine synthase (MTR) and methionine synthase reductase (MTRR), play an important function in the metabolism of folic acid and vitamin B12.… read more here.
Keywords: genotype frequencies; allele genotype; childhood caries; mtrr ... See more keywords