The UPR-PERK pathway is not a promising therapeutic target for mutant SOD1-induced ALS
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DOI: 10.1016/j.nbd.2019.03.024
Abstract: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease, characterized by motor neuron death in the brain and spinal cord. Mutations in the Cu/Zn superoxide dismutase (SOD1) gene account for ~20% of all familial ALS… read more here.
Keywords: mtsod1; upr perk; perk pathway; disease ... See more keywords