Selective Cell Penetrating Peptide‐Functionalized Polymersomes Mediate Efficient and Targeted Delivery of Methotrexate Disodium to Human Lung Cancer In Vivo
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DOI: 10.1002/adhm.201701135
Abstract: It is a long challenge to develop nanomedicines that simultaneously possess tumor cell selectivity and penetration functions. Here, it is reported that selective cell penetrating peptide (RLWMRWYSPRTRAYGC)-functionalized polymersomes (SCPP-PS) mediate efficient and targeted delivery of… read more here.
Keywords: efficient targeted; lung; mtx; lung cancer ... See more keywords
A Novel Strategy for Treating Inflammatory Bowel Disease by Targeting Delivery of Methotrexate through Glucan Particles.
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DOI: 10.1002/adhm.201901805
Abstract: Therapy of inflammatory bowel disease (IBD) has been a difficult task in the medical field. There is a great clinical need for more effective treatments for IBD. Herein, a targeted oral delivery system of yeast… read more here.
Keywords: glucan particles; bowel disease; inflammatory bowel; delivery ... See more keywords
Ineffectiveness of high‐dose methotrexate for prevention of CNS relapse in diffuse large B‐cell lymphoma
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DOI: 10.1002/ajh.26181
Abstract: Central nervous system (CNS) relapse affects 5% of diffuse large B‐cell lymphoma (DLBCL) patients and portends a poor prognosis. Prophylactic intravenous high‐dose methotrexate (HD‐MTX) is frequently employed to reduce this risk, but there is limited… read more here.
Keywords: lymphoma; risk; cns relapse; cns ... See more keywords
Methotrexate Versus Mycophenolate Mofetil Prophylaxis in Allogeneic Hematopoietic Cell Transplantation for Chronic Myeloid Malignancies: A Retrospective Analysis on Behalf of the Chronic Malignancies Working Party of the EBMT
Sign Up to like & getrecommendations! Published in 2024 at "American Journal of Hematology"
DOI: 10.1002/ajh.27531
Abstract: Prophylaxis strategies for Graft versus host disease (GVHD) in allogeneic hematopoietic cell transplantation (allo‐HCT) frequently encompass a combination of a calcineurin inhibitor (CNI) with either methotrexate (MTX) or mycophenolate mofetil (MMF). The aim of this… read more here.
Keywords: mtx; cell transplantation; hematopoietic cell; prophylaxis ... See more keywords
MTXPK.org: A Clinical Decision Support Tool Evaluating High‐Dose Methotrexate Pharmacokinetics to Inform Post‐Infusion Care and Use of Glucarpidase
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.1957
Abstract: Methotrexate (MTX), an antifolate, is administered at high doses to treat malignancies in children and adults. However, there is considerable interpatient variability in clearance of high‐dose (HD) MTX. Patients with delayed clearance are at an… read more here.
Keywords: glucarpidase; support tool; decision support; mtx ... See more keywords
Effects of GLPG3970 on Sulfasalazine and Methotrexate Pharmacokinetics in Healthy Adults: Two Open‐Label, Phase I, Drug–Drug Interaction Studies
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DOI: 10.1002/cpt.3438
Abstract: GLPG3970 is a selective salt‐inducible kinase 2/3 inhibitor intended for the treatment of inflammatory diseases. In vitro studies suggest GLPG3970 strongly inhibits breast cancer resistance protein (BCRP), indicating a possible interaction with BCRP substrates such… read more here.
Keywords: ssz; bcrp; glpg3970; drug ... See more keywords
Association between SLCO1A2 genetic variation and methotrexate toxicity in human rheumatoid arthritis treatment.
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DOI: 10.1002/jbt.22513
Abstract: Methotrexate (MTX), one of the important disease-modifying anti-rheumatic drugs, is the first-line drug for rheumatoid arthritis (RA) treatment. However, its adverse drug effects (ADEs) often lead to the abortion of MTX therapy. Human organic anion-transporting… read more here.
Keywords: treatment; toxicity; slco1a2 genetic; mtx ... See more keywords
The key role of organic anion transporter 3 in the drug-drug interaction between tranilast and methotrexate.
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DOI: 10.1002/jbt.22983
Abstract: Tranilast, N-(3',4'-dimethoxycinnamoyl)-anthranilic acid, is an anti-allergic drug and is considered for use in the treatment of rheumatoid arthritis. Methotrexate, an antimetabolite and folate antagonist to treat some cancers, is also a first-line drug for RA.… read more here.
Keywords: mtx; drug drug; drug; methotrexate ... See more keywords
Protective Role of Silymarin Against Methotrexate Induced Nephropathy in Rabbits
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DOI: 10.1002/jbt.70544
Abstract: The experiment aimed to investigate the protective effects of Silymarin (SMN) against methotrexate (MTX) induced nephropathy in rabbits. In a randomized control trial, a total of 20 rabbits were allocated into 4 different groups each… read more here.
Keywords: nephropathy rabbits; group; induced nephropathy; mtx ... See more keywords
Molecular mechanisms underlying methotrexate-induced intestinal injury and protective strategies
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DOI: 10.1007/s00210-024-03164-x
Abstract: Methotrexate (MTX) is a folic acid reductase inhibitor that manages various malignancies as well as immune-mediated inflammatory chronic diseases. Despite being frequently prescribed, MTX’s severe multiple toxicities can occasionally limit its therapeutic potential. Intestinal toxicity… read more here.
Keywords: induced intestinal; molecular mechanisms; intestinal injury; injury ... See more keywords
Multifunctional N,S co-doped carbon dots for sensitive probing of temperature, ferric ion, and methotrexate
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DOI: 10.1007/s00216-019-01617-4
Abstract: AbstractIn this paper, we have presented a facile method to fabricate nitrogen and sulfur co-doped carbon dots (N,S-CDs) for blood methotrexate (MTX) sensing applications. The N,S-CDs with quantum yield up to 75% were obtained by… read more here.
Keywords: temperature; doped carbon; methotrexate; carbon dots ... See more keywords