Selective Cell Penetrating Peptide‐Functionalized Polymersomes Mediate Efficient and Targeted Delivery of Methotrexate Disodium to Human Lung Cancer In Vivo
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DOI: 10.1002/adhm.201701135
Abstract: It is a long challenge to develop nanomedicines that simultaneously possess tumor cell selectivity and penetration functions. Here, it is reported that selective cell penetrating peptide (RLWMRWYSPRTRAYGC)-functionalized polymersomes (SCPP-PS) mediate efficient and targeted delivery of… read more here.
Keywords: efficient targeted; lung; mtx; lung cancer ... See more keywords
A Novel Strategy for Treating Inflammatory Bowel Disease by Targeting Delivery of Methotrexate through Glucan Particles.
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DOI: 10.1002/adhm.201901805
Abstract: Therapy of inflammatory bowel disease (IBD) has been a difficult task in the medical field. There is a great clinical need for more effective treatments for IBD. Herein, a targeted oral delivery system of yeast… read more here.
Keywords: glucan particles; bowel disease; inflammatory bowel; delivery ... See more keywords
Ineffectiveness of high‐dose methotrexate for prevention of CNS relapse in diffuse large B‐cell lymphoma
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DOI: 10.1002/ajh.26181
Abstract: Central nervous system (CNS) relapse affects 5% of diffuse large B‐cell lymphoma (DLBCL) patients and portends a poor prognosis. Prophylactic intravenous high‐dose methotrexate (HD‐MTX) is frequently employed to reduce this risk, but there is limited… read more here.
Keywords: lymphoma; risk; cns relapse; cns ... See more keywords
MTXPK.org: A Clinical Decision Support Tool Evaluating High‐Dose Methotrexate Pharmacokinetics to Inform Post‐Infusion Care and Use of Glucarpidase
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DOI: 10.1002/cpt.1957
Abstract: Methotrexate (MTX), an antifolate, is administered at high doses to treat malignancies in children and adults. However, there is considerable interpatient variability in clearance of high‐dose (HD) MTX. Patients with delayed clearance are at an… read more here.
Keywords: glucarpidase; support tool; decision support; mtx ... See more keywords
Association between SLCO1A2 genetic variation and methotrexate toxicity in human rheumatoid arthritis treatment.
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DOI: 10.1002/jbt.22513
Abstract: Methotrexate (MTX), one of the important disease-modifying anti-rheumatic drugs, is the first-line drug for rheumatoid arthritis (RA) treatment. However, its adverse drug effects (ADEs) often lead to the abortion of MTX therapy. Human organic anion-transporting… read more here.
Keywords: treatment; toxicity; slco1a2 genetic; mtx ... See more keywords
The key role of organic anion transporter 3 in the drug-drug interaction between tranilast and methotrexate.
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DOI: 10.1002/jbt.22983
Abstract: Tranilast, N-(3',4'-dimethoxycinnamoyl)-anthranilic acid, is an anti-allergic drug and is considered for use in the treatment of rheumatoid arthritis. Methotrexate, an antimetabolite and folate antagonist to treat some cancers, is also a first-line drug for RA.… read more here.
Keywords: mtx; drug drug; drug; methotrexate ... See more keywords
Multifunctional N,S co-doped carbon dots for sensitive probing of temperature, ferric ion, and methotrexate
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DOI: 10.1007/s00216-019-01617-4
Abstract: AbstractIn this paper, we have presented a facile method to fabricate nitrogen and sulfur co-doped carbon dots (N,S-CDs) for blood methotrexate (MTX) sensing applications. The N,S-CDs with quantum yield up to 75% were obtained by… read more here.
Keywords: temperature; doped carbon; methotrexate; carbon dots ... See more keywords
Acute kidney injury, agranulocytosis, drug-induced liver injury, and posterior reversible encephalopathy syndrome caused by high-dose methotrexate—possible role of low activity ABC and SLC drug transporters
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DOI: 10.1007/s00228-018-2485-6
Abstract: Methotrexate (MTX) is an essential drug in the treatment of acute lymphoblastic leukemia (ALL). High-dose methotrexate (HD-MTX) administration (> 1 g/m) can lead to its tubular precipitation, leading to acute kidney injury (AKI) and other… read more here.
Keywords: high dose; drug; mtx; dose methotrexate ... See more keywords
Brentuximab vedotin is effective for rheumatoid arthritis in a patient with relapsed methotrexate-associated Hodgkin lymphoma
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DOI: 10.1007/s00277-018-3279-8
Abstract: Dear Editor, We encountered a 55-year-old female with a 12-year history of rheumatoid arthritis (RA) and she had been taking methotrexate (MTX) for 10 years. Although MTX resulted in a good control of the RA… read more here.
Keywords: lymphoma; hodgkin lymphoma; disease; mtx lpd ... See more keywords
Usefulness of noninvasive diagnostic procedures for assessment of methotrexate hepatotoxicity in patients with rheumatoid arthritis
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DOI: 10.1007/s00296-021-05059-z
Abstract: Methotrexate (MTX) is recommended as a first-line treatment for rheumatoid arthritis (RA). There are no strict guidelines regarding monitoring for liver damage in RA patients. This study aimed to evaluate noninvasive diagnostic procedures in assessing… read more here.
Keywords: mtx; diagnostic procedures; rheumatoid arthritis; liver fibrosis ... See more keywords
Earlier predictors for treatment outcome among single dose methotrexate for an ectopic pregnancy
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DOI: 10.1007/s00404-019-05250-5
Abstract: We read with great interest the study of Brunello et al. in a recent issue of the Journal [1]. The authors address the important issue of early prediction of methotrexate (MTX) treatment success for an… read more here.
Keywords: treatment success; treatment; success; mtx ... See more keywords