Protective effects of apigenin on altered lipid peroxidation, inflammation, and antioxidant factors in methotrexate-induced hepatotoxicity.
Sign Up to like & getrecommendations! Published in 2020 at "Naunyn-Schmiedeberg's archives of pharmacology"
DOI: 10.1007/s00210-020-01991-2
Abstract: Methotrexate (MTX) is used as an effective chemotherapeutic agent against autoimmune diseases and tumors. Oxidative stress and inflammation are involved in the pathogenesis of MTX-induced damage. This study aimed at examining the ameliorating effects of… read more here.
Keywords: induced hepatotoxicity; group; inflammation; mtx induced ... See more keywords
Methotrexate‐induced pneumonia: A dermatologist wake up call
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DOI: 10.1111/dth.12557
Abstract: Dear Editor, Methotrexate (MXT) is an immunosuppressant folic acid antagonist medication, often used by dermatologists for psoriasis and other skin conditions (Hammerschmidt & Brenner, 2014). MTX-induced pneumonitis (MIP) is an uncommon adverse reaction of MXT.… read more here.
Keywords: methotrexate; mtx; rheumatoid arthritis; mtx induced ... See more keywords
THU0171 Identification of methotrexate-induced pulmonary toxicity cases in a fully searchable routine clinical database
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.7126
Abstract: Background Methotrexate (MTX) remains the favoured disease-modifying anti-rheumatic drug for the treatment of rheumatoid arthritis (RA) and is frequently used in other inflammatory conditions. However, side effects are frequent and toxicity is of concern, especially… read more here.
Keywords: methotrexate; induced pulmonary; mtx; mtx induced ... See more keywords
Diosmin Attenuates Methotrexate-Induced Hepatic, Renal, and Cardiac Injury: A Biochemical and Histopathological Study in Mice
Sign Up to like & getrecommendations! Published in 2017 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2017/3281670
Abstract: The current study was designed to investigate the beneficial role of diosmin, a biologically active flavonoid, against methotrexate- (MTX-) induced hepatic, renal, and cardiac injuries in mice. Male Swiss albino mice received a single intraperitoneal… read more here.
Keywords: hepatic renal; renal cardiac; diosmin; mtx induced ... See more keywords
Methotrexate-Induced Nephrotoxicity in Rats: Protective Effect of Mistletoe (Viscum album L.) Extract
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DOI: 10.1159/000468984
Abstract: Background: The protective effect of mistletoe extract (Helixor®, HLX) against methotrexate (MTX)-induced acute oxidative stress and nephrotoxicity in rats was evaluated by histological and biochemical methods as well as the comet assay. Material and Methods:… read more here.
Keywords: nephrotoxicity rats; group; hlx; mtx induced ... See more keywords
Aminoguanidine pretreatment prevents methotrexate-induced small intestinal injury in the rat by attenuating nitrosative stress and restoring the activities of vital mitochondrial enzymes
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Basic and Clinical Physiology and Pharmacology"
DOI: 10.1515/jbcpp-2016-0099
Abstract: Abstract Background: One of the major toxic side effects of methotrexate (MTX) is enterocolitis, for which there is no efficient standard treatment. Nitric oxide overproduction has been reported to play an important role in MTX-induced… read more here.
Keywords: aminoguanidine pretreatment; induced mucositis; mtx; mtx induced ... See more keywords
Combination of Vitamin C and Curcumin Safeguards Against Methotrexate-Induced Acute Liver Injury in Mice by Synergistic Antioxidant Effects
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.866343
Abstract: Methotrexate (MTX), an antineoplastic and immunosuppressive drug, widely used in the treatment of different types of cancers and the management of chronic inflammatory diseases. However, its use is associated with hepatotoxicity. Vitamin C (VC) and… read more here.
Keywords: mtx induced; combination; group; hepatotoxicity ... See more keywords
Punicalagin Protects against the Development of Methotrexate-Induced Hepatotoxicity in Mice via Activating Nrf2 Signaling and Decreasing Oxidative Stress, Inflammation, and Cell Death
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DOI: 10.3390/ijms232012334
Abstract: Despite its effectiveness in treating inflammatory diseases and various malignancies, methotrexate (MTX) is well known to cause hepatotoxicity, which involves increased oxidative stress and inflammation, limiting its clinical use. Herein, we looked into the effect… read more here.
Keywords: mtx induced; oxidative stress; induced hepatotoxicity; mice ... See more keywords
Ginkgo biloba Extract Protects against Methotrexate-Induced Hepatotoxicity: A Computational and Pharmacological Approach
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DOI: 10.3390/molecules25112540
Abstract: Ginkgo biloba extract possess several promising biological activities; currently, it is clinically employed in the management of several diseases. This research work aimed to extrapolate the antioxidant and anti-inflammatory effects of Ginkgo biloba (Gb) in… read more here.
Keywords: ginkgo biloba; methotrexate induced; extract protects; biloba extract ... See more keywords
Dihydromyricetin Modulates Nrf2 and NF-κB Crosstalk to Alleviate Methotrexate-Induced Lung Toxicity
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DOI: 10.3390/ph16040481
Abstract: Background: Methotrexate (MTX) is an effective anticancer, anti-inflammatory, and immunomodulatory agent. However, it induces a serious pneumonitis that leads to irreversible fibrotic lung damage. This study addresses the protective role of the natural flavonoid dihydromyricetin… read more here.
Keywords: mtx induced; dhm; mtx; dihydromyricetin modulates ... See more keywords