Methotrexate reduces vaccine-specific immunoglobulin levels but not numbers of circulating antibody-producing B cells in rheumatoid arthritis after vaccination with a conjugate pneumococcal vaccine.
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DOI: 10.1016/j.vaccine.2016.12.068
Abstract: BACKGROUND Treatment with methotrexate (MTX) in patients with rheumatoid arthritis (RA) leads to decreased total immunoglobulin (Ig) levels and impairs vaccine-specific IgG antibody levels following pneumococcal vaccination. The mechanisms by which MTX exerts these effects… read more here.
Keywords: mtx patients; vaccine; vaccine specific; antibody ... See more keywords