Recombinant nanobody against MUC1 tandem repeats inhibits growth, invasion, metastasis and vascularization of spontaneous mouse mammary tumors.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13123
Abstract: Alteration in glycosylation pattern of MUC1 mucin tandem repeats during carcinomas has been shown to negatively affect adhesive properties of malignant cells and enhance tumor invasiveness and metastasis. In addition, MUC1 overexpression is closely interrelated… read more here.
Keywords: muc1; nanobody; muc1 tandem; tandem repeats ... See more keywords
Photo-Controlled MUC1 Ablation via Steric Locking of Turn-On Reactors Enhances Pyroptosis-Immunotherapy of Triple Negative Breast Cancer.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced materials"
DOI: 10.1002/adma.202504460
Abstract: Mucin 1 (MUC1) is aberrantly upregulated in triple-negative breast cancer (TNBC) cells and presents major roles in orchestrating TNBC pathogenesis and therapeutic resistance. Herein, a bioorthogonal MUC1-binding strategy is reported to install MUC1-lockable aggregation-induced emission… read more here.
Keywords: breast cancer; muc1; pyroptosis; negative breast ... See more keywords
MUC1 as a target for CAR‐T therapy in head and neck squamous cell carinoma
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.2733
Abstract: The modification of chimeric antigen receptor (CAR) endowing T cells with tumor‐specific cytotoxicity induces antitumor immunity. However, the structural characteristics of solid tumors, the loss of specific antigens, and the strong immunosuppressive environment are challenges… read more here.
Keywords: neck squamous; muc1; car; car therapy ... See more keywords
Downregulation of MUC1 Enhances Antitumor Response in Colon Cancer Model by Decreasing PD‐L1 Expression In Vivo and In Vitro
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70538
Abstract: Colorectal cancer (CRC) is a cancer with poor 5‐year survival rates. The exploration of biomarkers and potential mechanisms for the diagnosis and treatment of CRC is crucial in clinical practice. The transmembrane glycoprotein Mucin 1… read more here.
Keywords: cancer; muc1; response; enhances antitumor ... See more keywords
MUC‐1 aptamer targeted superparamagnetic iron oxide nanoparticles for magnetic resonance imaging of pancreatic cancer in vivo and in vitro experiment
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28950
Abstract: This study aims to explore the ability of magnetic resonance imaging (MRI) in mucin 1 (MUC1) modified superparamagnetic iron oxide nanoparticle (SPION) targeting human pancreatic cancer (PC). The MUC1 target‐directed probe was prepared through MUC1… read more here.
Keywords: vivo; muc1; magnetic resonance; pancreatic cancer ... See more keywords
Administration of dexamethasone disrupts endometrial receptivity by alteration of expression of miRNA 223, 200a, LIF, Muc1, SGK1, and ENaC via the ERK1/2‐mTOR pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28562
Abstract: Successful implantation of embryos requires endometrial receptivity. Glucocorticoids are one of the factors influencing the implantation window. In this study, 40 female BALB/c mice were used to study the impacts of dexamethasone administration on endometrial… read more here.
Keywords: muc1; expression; mtor; dexamethasone ... See more keywords
Role of glycosylation on the ensemble of conformations in the MUC1 immunodominant epitope
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Peptide Science"
DOI: 10.1002/psc.3229
Abstract: MUC1 is a membrane glycoprotein, which in adenocarninomas is overexpressed and exhibits truncated O‐glycosylation. Overexpression and altered glycosylation make MUC1 into a candidate for immunotherapy. Monoclonal antibodies directed against MUC1 frequently bind an immunodominant epitope… read more here.
Keywords: immunodominant epitope; role glycosylation; muc1; glycosylation ... See more keywords
Silicon nanodot-based aptasensor for fluorescence turn-on detection of mucin 1 and targeted cancer cell imaging.
Sign Up to like & getrecommendations! Published in 2018 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2018.06.032
Abstract: We report herein a new dual-color fluorescent aptasensor for detection of tumor marker mucin 1 (MUC1) and targeted imaging of MCF-7 cancer cells based on the specific interaction between MUC1 and its aptamer S2.2. The… read more here.
Keywords: detection; mucin; fluorescence; muc1 ... See more keywords
Regulation of mucin 1 expression and its relationship with oral diseases.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2020.104791
Abstract: OBJECTIVE The aim of this study is to describe the polymorphic mucin 1 (MUC1), and to provide an overview of the known complex and multiple functions of MUC1 in normal oral mucosa and oral mucosal… read more here.
Keywords: mucin expression; muc1; regulation mucin; expression relationship ... See more keywords
Muc1 deficiency exacerbates pulmonary fibrosis in a mouse model of silicosis.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.09.047
Abstract: BACKGROUND MUC1 (MUC in human and Muc in animals) is a membrane-tethered mucin expressed on the apical surface of lung epithelial cells. However, in the lungs of patients with interstitial lung disease, MUC1 is aberrantly… read more here.
Keywords: muc1; pulmonary fibrosis; muc1 deficiency; lung ... See more keywords
Anti-PD1 antibody enhances the anti-tumor efficacy of MUC1-MBP fusion protein vaccine via increasing Th1, Tc1 activity and decreasing the proportion of MDSC in the B16-MUC1 melanoma mouse model.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.108173
Abstract: In previous studies, we have obtained a notable anti-tumor efficacy of the recombinant MUC1-MBP vaccine in the process of mouse B16-MUC1 melanoma treatment. However, the tumor cannot be eliminated completely. We found that the tumor… read more here.
Keywords: muc1; tumor efficacy; anti tumor; muc1 mbp ... See more keywords