Pseudomonas aeruginosa increases MUC1 expression in macrophages through the TLR4-p38 pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.08.056
Abstract: Alveolar macrophages (AMs) play a critical role in the clearance of Pseudomonas aeruginosa (Pa) from the airways. However, hyper-activation of macrophages can impair bacterial clearance and contribute to morbidity and mortality. MUC1 mucin is a… read more here.
Keywords: expression macrophages; pseudomonas aeruginosa; muc1 expression; tlr4 p38 ... See more keywords
Activation of Vitamin D/VDR Signaling Reverses Gemcitabine Resistance of Pancreatic Cancer Cells Through Inhibition of MUC1 Expression.
Sign Up to like & getrecommendations! Published in 2022 at "Digestive diseases and sciences"
DOI: 10.1158/1538-7445.am2022-6367
Abstract: BACKGROUND Pancreatic ductal adenocarcinoma (PDA) has a poor prognosis due to its therapeutic resistance. Inactivation of vitamin D/vitamin D receptor (VDR) signaling may contribute to the malignant phenotype of PDA and altered expression of oncoprotein… read more here.
Keywords: vitamin vdr; expression; resistance; vdr signaling ... See more keywords