Exopolysaccharides from Lactobacillus plantarum NCU116 enhances colonic mucosal homeostasis by controlling epithelial cells differentiation and c-Jun/Muc2 signaling.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b03939
Abstract: Probiotic lactobacilli and their exopolysaccharides (EPS) are thought to modulate mucosal homeostasis，however, its mechanisms remain elusive. Thus, we tried to clarify the role of exopolysaccharides from Lactobacillus plantarum NCU116 (EPS116) in the intestinal mucosal homeostasis.… read more here.
Keywords: homeostasis; jun; muc2; mucosal ... See more keywords
Intestinal Muc2 mucin O-glycosylation is affected by microbiota and regulated by differential expression of glycosyltranferases
Sign Up to like & getrecommendations! Published in 2017 at "Glycobiology"
DOI: 10.1093/glycob/cww134
Abstract: Intestinal cells are covered by mucus. In the small intestine, a single unattached mucus is present whereas the colon has both an inner attached mucus layer and an outer loose mucus. The attached mucus of… read more here.
Keywords: along intestine; muc2; mucus; muc2 mucin ... See more keywords
Prognostic significance of MUC2, CDX2 and SOX2 in stage II colorectal cancer patients
Sign Up to like & getrecommendations! Published in 2021 at "BMC Cancer"
DOI: 10.1186/s12885-021-08070-6
Abstract: Background Colorectal cancer (CRC) remains a serious health concern worldwide. Despite advances in diagnosis and treatment, about 15 to 30% of stage II CRC patients subjected to tumor resection with curative intent, develop disease relapse.… read more here.
Keywords: stage crc; muc2; expression; cancer ... See more keywords
Immunohistochemical expression of mucin antigens in gallbladder adenocarcinoma: MUC1-positive and MUC2-negative expression Is associated with vessel invasion and shortened survival.
Sign Up to like & getrecommendations! Published in 2017 at "Histology and histopathology"
DOI: 10.14670/hh-11-824
Abstract: Mucins play pivotal roles in influencing cancer biology, for example affecting carcinoma invasion, aggressiveness and/or metastatic potential. Our aim is to investigate the significance of expression profiles of two mucins in particular, MUC1 and MUC2,… read more here.
Keywords: vessel invasion; invasion; muc1; gallbladder adenocarcinoma ... See more keywords
MUC2 mucin deficiency alters inflammatory and metabolic pathways in the mouse intestinal mucosa
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.16886
Abstract: The mucus layer in the intestine affects several aspects of intestinal biology, encompassing physical, chemical protection, immunomodulation and growth, thus contributing to homeostasis. Mice with genetic inactivation of the Muc2 gene, encoding the MUC2 mucin,… read more here.
Keywords: metabolic pathways; muc2; muc2 mucin; expression ... See more keywords
The Effect of Endotoxin on the Intestinal Mucus Layer in Non- and Post-pregnancy Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2021.824170
Abstract: The intestine is the most extensive storage organ of bacteria and endotoxins, and the mucosal immune system is the first barrier of the intestine. Mucin-2 (MUC2) is the major component of the mucus layers. In… read more here.
Keywords: lps group; mucus; muc2; significantly decreased ... See more keywords
Expression of inositol-requiring enzyme 1β is downregulated in colorectal cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncology Letters"
DOI: 10.3892/ol.2017.5590
Abstract: The endoplasmic reticulum stress inositol-requiring enzyme (IRE) 1α/X-box binding protein (XBP) 1 signaling pathway is involved in the tumorigenesis of breast and prostate cancer. Mucin 2 (MUC2) protects colon tissues from the formation of tumors.… read more here.
Keywords: muc2; expression; expression levels; cancer ... See more keywords
GATA4 Forms a Positive Feedback Loop with CDX2 to Transactivate MUC2 in Bile Acids-Induced Gastric Intestinal Metaplasia.
Sign Up to like & getrecommendations! Published in 2023 at "Gut and liver"
DOI: 10.5009/gnl220394
Abstract: Background/Aims Gastric intestinal metaplasia (GIM), a common precancerous lesion of gastric cancer, can be caused by bile acid reflux. GATA binding protein 4 (GATA4) is an intestinal transcription factor involved in the progression of gastric… read more here.
Keywords: gastric intestinal; gata4; cdx2; muc2 ... See more keywords