MUCIN-4 (MUC4) is a novel tumor antigen in pancreatic cancer immunotherapy.
Sign Up to like & getrecommendations! Published in 2020 at "Seminars in immunology"
DOI: 10.1016/j.smim.2020.101391
Abstract: Pancreatic cancer (PC) is a highly lethal malignancy with a dismal five-year survival rate. This is due to its asymptomatic nature, lack of reliable biomarkers, poor resectability, early metastasis, and high recurrence rate. Limited efficacies… read more here.
Keywords: muc4; treatment; tumor antigen; immunotherapy ... See more keywords
MUC4 is overexpressed in idiopathic pulmonary fibrosis and collaborates with transforming growth factor β inducing fibrotic responses.
Sign Up to like & getrecommendations! Published in 2020 at "Mucosal immunology"
DOI: 10.1038/s41385-020-00343-w
Abstract: Several mucins are implicated in idiopathic pulmonary fibrosis (IPF); however, there is no evidence regarding the role of MUC4 in the development of IPF. Here we demonstrated that MUC4 was overexpressed in IPF patients (n = 22)… read more here.
Keywords: fibrosis; idiopathic pulmonary; muc4; pulmonary fibrosis ... See more keywords
The role of membrane mucin MUC4 in breast cancer metastasis.
Sign Up to like & getrecommendations! Published in 2021 at "Endocrine-related cancer"
DOI: 10.1530/erc-21-0083
Abstract: A major barrier to the emergence of distant metastases is the survival of circulating tumor cells (CTCs) within the vasculature. Lethal stressors including shear forces from blood flow, anoikis arising from cellular detachment, and exposure… read more here.
Keywords: metastasis; cancer; breast cancer; muc4 ... See more keywords
NIDO, AMOP and vWD domains of MUC4 play synergic role in MUC4 mediated signaling
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.14420
Abstract: MUC4 mucin is well known as an important potential target to overcome pancreatic cancer. Three unique domains (NIDO, AMOP, and vWD) with unclear roles only present in MUC4 but are not found in other membrane-bound… read more here.
Keywords: nido amop; muc4; muc4 mediated; amop vwd ... See more keywords
Radiomics models based on multi-sequence MRI for preoperative evaluation of MUC4 status in pancreatic ductal adenocarcinoma: a preliminary study
Sign Up to like & getrecommendations! Published in 2022 at "Quantitative Imaging in Medicine and Surgery"
DOI: 10.21037/qims-22-112
Abstract: Background Mucin 4 (MUC4) overexpression promotes tumorigenesis and increases the aggressiveness of pancreatic ductal adenocarcinoma (PDAC). To date, no study has reported the association between radiomics and MUC4 expression in PDAC. Thus, we aimed to… read more here.
Keywords: based multi; expression; multi sequence; mri ... See more keywords
Association Study between Mucin 4 (MUC4) Polymorphisms and Idiopathic Recurrent Pregnancy Loss in a Korean Population
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13060937
Abstract: Recurrent pregnancy loss (RPL) is the loss of two or more consecutive pregnancies before 20 weeks of gestational age. Our study investigated whether mucin 4 (MUC4) polymorphisms are associated with RPL. MUC polymorphisms (rs882605 C>A,… read more here.
Keywords: loss; recurrent pregnancy; mucin muc4; muc4 ... See more keywords