Protective role of overexpressed MUC5AC against fibrosis in MHV‐68‐induced combined pulmonary fibrosis and emphysema mouse model
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Medical Virology"
DOI: 10.1002/jmv.26094
Abstract: Mucins have long been regarded to play a role as a barrier to prevent mucosal infections; however, some studies report that overexpression of mucins induces obstruction and inflammation of airways. We investigated whether the secretion… read more here.
Keywords: fibrosis; muc5ac; role; mouse model ... See more keywords
Expression and Serum Levels of Mucin 5AC (MUC5AC) as a Biomarker for Cholangiocarcinoma: a Meta-analysis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Gastrointestinal Cancer"
DOI: 10.1007/s12029-017-0032-9
Abstract: AimThe potential of biomarkers in detecting early cholangiocarcinoma (CCA) is facilitated by examining CCA-associated proteins from primary studies. One such protein is mucin 5AC (MUC5AC) but inconsistency of reported associations between its expression/serum levels and… read more here.
Keywords: mucin 5ac; analysis; muc5ac; expression serum ... See more keywords
Ramifications of secreted mucin MUC5AC in malignant journey: a holistic view
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DOI: 10.1093/carcin/bgy019
Abstract: Heavily glycosylated secreted mucin MUC5AC, by the virtue of its cysteine-rich repeats, can form inter- and intramolecular disulfide linkages resulting in complex polymers, which in turn craft the framework of the polymeric mucus gel on… read more here.
Keywords: malignant journey; muc5ac; secreted mucin; mucin muc5ac ... See more keywords
Analysis of blood group antigens on MUC5AC in mucinous ovarian cancer tissues using in situ proximity ligation assay.
Sign Up to like & getrecommendations! Published in 2021 at "Glycobiology"
DOI: 10.1093/glycob/cwab090
Abstract: MUC5AC has been indicated to be a marker for mucinous ovarian cancer (OC). We investigated the use of in situ proximity ligation assay (PLA) for blood group ABH expressing MUC5AC to differentiate between serous and… read more here.
Keywords: pla; secretor; muc5ac; ovarian cancer ... See more keywords
Molecular insight of p53/Sp1/MUC5AC axis in the tumorigenesis and progression of lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13720
Abstract: The aberrant expression of secretory mucin MUC5AC has been documented during the tumourigenesis and progression of various cancers. However, little is currently known on the function of MUC5AC in lung adenocarcinoma. The present study focused… read more here.
Keywords: lung adenocarcinoma; sp1; progression; muc5ac ... See more keywords
Secretory Mucin 5AC Promotes Neoplastic Progression by Augmenting KLF4-Mediated Pancreatic Cancer Cell Stemness
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DOI: 10.1158/0008-5472.can-20-1293
Abstract: This study elucidates that de novo expression of MUC5AC promotes cancer cell stemness during Kras-driven pancreatic tumorigenesis and can be targeted for development of a novel therapeutic regimen. Secreted mucin 5AC (MUC5AC) is the most… read more here.
Keywords: muc5ac; cancer; cell stemness; cancer cell ... See more keywords
Abstract 4053: Mucin 5ac as a potential therapeutic target for KRAS-driven lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-4053
Abstract: Lung cancer continues to be the leading cause of cancer death in the United States, with more than 140,000 deaths per year. One of the main types of lung cancer is non-small cell lung cancer… read more here.
Keywords: lung adenocarcinoma; mucin 5ac; muc5ac; lung cancer ... See more keywords
Abstract 1283: MUC5AC promotes brain metastases and colonization in non small cell lung cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1283
Abstract: Background: Non-small cell lung adenocarcinoma (NSCLC), constitutes 80-85% of the lung cancers. The 5-year survival of patients with metastatic lung cancer is only 5%. Additionally, the prognosis worsens in NSCLC patients (40-50%) that have developed… read more here.
Keywords: metastasis; cell; muc5ac; brain ... See more keywords
PM2.5 Upregulates the Expression of MUC5AC via the EGFR-PI3K Pathway in Human Sinonasal Epithelial Cells.
Sign Up to like & getrecommendations! Published in 2021 at "International archives of allergy and immunology"
DOI: 10.1159/000519702
Abstract: BACKGROUND Fine particulate matter (PM) (PM with an aerodynamic diameter read more here.
Keywords: pm2; pi3k; egfr; muc5ac ... See more keywords
Mucins MUC5AC and MUC5B in the Airways: MUCing around Together
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DOI: 10.1164/rccm.202208-1459ed
Abstract: Chronic obstructive pulmonary disease (COPD) and chronic asthma clinically manifest with sputum production and cough, which correlate with pathologic features such as mucin hypersecretion and airway lumenal mucus accumulation (1, 2). Increased mucin and mucus… read more here.
Keywords: mucins muc5ac; muc5ac; muc5ac muc5b; mucus ... See more keywords
Evaluation of serum MUC5AC in combination with CA19-9 for the diagnosis of pancreatic cancer
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DOI: 10.1186/s12957-020-1809-z
Abstract: Background Pancreatic cancer (PC) is a highly aggressive tumor with a poor prognosis that lacks specific diagnostic markers. Mucin 5AC (MUC5AC) is a member of the mucin family, a heterogeneous group of high molecular weight,… read more here.
Keywords: combination; ca19; serum muc5ac; pancreatic cancer ... See more keywords