Diesel exhaust particles elevate MUC5AC and MUC5B expression via the TLR4-mediated activation of ERK1/2, p38 MAPK, and NF-κB signaling pathways in human airway epithelial cells.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.02.146
Abstract: Exposure to diesel exhaust particles (DEPs) is known to cause serious health problems, owing to a steady increase in the number of diesel vehicles worldwide. DEPs comprise approximately 90% particle mass existing in the fine… read more here.
Keywords: signaling pathways; epithelial cells; airway epithelial; expression ... See more keywords
Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of respiratory and critical care medicine"
DOI: 10.1164/rccm.202202-0309oc
Abstract: RATIONALE MUC5AC and MUC5B are the predominant secreted polymeric mucins in mammalian airways. They contribute differently to the pathogenesis of various muco-obstructive and interstitial lung diseases, and their genes are separately regulated, but whether they… read more here.
Keywords: muc5b variably; muc5ac muc5b; secretory granules; separate secretory ... See more keywords
Obesity, Insulin Resistance, and Asthma
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Respiratory and Critical Care Medicine"
DOI: 10.1164/rccm.202207-1271ed
Abstract: et al. The polymeric mucin Muc5ac is required for allergic airway hyperreactivity. Nat Commun 2015;6:6281. 9. Radicioni G, Ceppe A, Ford AA, Alexis NE, Barr RG, Bleecker ER, et al. Airway mucin MUC5AC and MUC5B… read more here.
Keywords: lancet respir; insulin resistance; obesity insulin; med 2019 ... See more keywords
Mucins MUC5AC and MUC5B in the Airways: MUCing around Together
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Respiratory and Critical Care Medicine"
DOI: 10.1164/rccm.202208-1459ed
Abstract: Chronic obstructive pulmonary disease (COPD) and chronic asthma clinically manifest with sputum production and cough, which correlate with pathologic features such as mucin hypersecretion and airway lumenal mucus accumulation (1, 2). Increased mucin and mucus… read more here.
Keywords: mucins muc5ac; muc5ac; muc5ac muc5b; mucus ... See more keywords
Cold air alters MUC5AC and MUC5B expression in the airways of asthma patients
Sign Up to like & getrecommendations! Published in 2018 at "European Respiratory Journal"
DOI: 10.1183/13993003.congress-2018.pa1272
Abstract: Background: Cold airway hyperresponsiveness (CAH) is common in asthma. However, it is not clear, if any changes in the expression of particular mucins are induced by cold air inhalation in vivo. Objectives: The aim of… read more here.
Keywords: asthma patients; muc5b expression; expression; cold air ... See more keywords
Serum MUC5AC protein levels are correlated with the development and severity of connective tissue disease-associated pulmonary interstitial lesions
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.987723
Abstract: Background Mucin 5AC (MUC5AC) and mucin 5B (MUC5B) are the major components of airway mucins. The expression levels of MUC5AC and MUC5B are related to connective tissue disease-associated interstitial lung disease (CTD-ILD) in the promoter… read more here.
Keywords: protein levels; ctd ild; severity; muc5ac muc5b ... See more keywords
Effect of Korean Red Ginseng and Rg3 on Asian Sand Dust-Induced MUC5AC, MUC5B, and MUC8 Expression in Bronchial Epithelial Cells
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26072002
Abstract: Korean Red ginseng (KRG), commonly used in traditional medicine, has anti-inflammatory, anti- oxidative, and anti-tumorigenic properties. Asian sand dust (ASD) is known to aggravate upper and lower airway inflammatory responses. BEAS-2B cells were exposed to… read more here.
Keywords: rg3; muc5ac muc5b; expression; muc5b muc8 ... See more keywords