Role of MUC5B during Group B Streptococcal Vaginal Colonization
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DOI: 10.1128/mbio.00039-22
Abstract: Mucin glycoproteins are a major component that contributes to the complexity of the female reproductive tract (FRT). Group B Streptococcus (GBS) is present in the FRT of 25–30% of healthy women, but during pregnancy can… read more here.
Keywords: colonization; frt; gbs; mucin ... See more keywords
Interaction between the promoter MUC5B polymorphism and mucin expression: is there a difference according to ILD subtype?
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DOI: 10.1136/thoraxjnl-2020-214579
Abstract: The MUC5B promoter variant rs35705950 is associated with idiopathic pulmonary fibrosis (IPF). MUC5B glycoprotein is overexpressed in IPF lungs. We examined immunohistochemical expression of MUC5B in different interstitial lung disease patterns according to rs35705950 T-allele… read more here.
Keywords: difference; muc5b; interaction promoter; promoter muc5b ... See more keywords
The Mucin Gene MUC5B Is Required for Normal Lung Function
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DOI: 10.1164/rccm.202201-0064ed
Abstract: Airways have a mucus lining that protects the lungs from the deleterious effects of exposure to inhaled particles, pathogens, and gases. Airway mucus is a gel in which the polymer network consists of heavily glycosylated… read more here.
Keywords: mucus gel; lung; pathology; airway mucus ... See more keywords
Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules.
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DOI: 10.1164/rccm.202202-0309oc
Abstract: RATIONALE MUC5AC and MUC5B are the predominant secreted polymeric mucins in mammalian airways. They contribute differently to the pathogenesis of various muco-obstructive and interstitial lung diseases, and their genes are separately regulated, but whether they… read more here.
Keywords: muc5b variably; muc5ac muc5b; secretory granules; separate secretory ... See more keywords
Epithelial ER Stress Enhances the Risk of Muc5b Associated Lung Fibrosis.
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DOI: 10.1165/rcmb.2022-0252oc
Abstract: The gain-of-function minor allele of the MUC5B promoter (rs35705950) is the strongest risk factor for idiopathic pulmonary fibrosis (IPF), a devastating fibrotic lung disease that leads to progressive respiratory failure in adults. We have previously… read more here.
Keywords: stress; lung fibrosis; mice; muc5b ... See more keywords
The MUC5B promoter polymorphism is associated with specific interstitial lung abnormality subtypes
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DOI: 10.1183/13993003.00537-2017
Abstract: The MUC5B promoter polymorphism (rs35705950) has been associated with interstitial lung abnormalities (ILA) in white participants from the general population; whether these findings are replicated and influenced by the ILA subtype is not known. We… read more here.
Keywords: muc5b promoter; promoter polymorphism; muc5b genotype; muc5b ... See more keywords
COVID-19 Survivor Patients Carrying the Rs35705950 Risk Allele in MUC5B Have Higher Plasma Levels of Mucin 5B
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DOI: 10.3390/cimb44080226
Abstract: Background: Genetic susceptibility to infectious diseases is partly due to the variation in the human genome, and COVID-19 is not the exception. This study aimed to identify whether risk alleles of known genes linked with… read more here.
Keywords: risk allele; levels mucin; plasma; risk ... See more keywords