LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "muc5b" as a keyword



Higher levels of neutrophil extracellular traps in mucoid middle ear effusion obtained from otitis media with effusion in children

Sign Up to like & get
recommendations! Published in 2025 at "Annals of Medicine"

DOI: 10.1080/07853890.2025.2587488

Abstract: Abstract Background The etiology of otitis media with effusion (OME) is multifactorial and complex, with increasing evidence implicating bacterial infection as a potential contributor. Neutrophil extracellular traps (NETs) have been identified as key participants in… read more here.

Keywords: neutrophil extracellular; effusion; media effusion; middle ear ... See more keywords

Role of MUC5B during Group B Streptococcal Vaginal Colonization

Sign Up to like & get
recommendations! Published in 2022 at "mBio"

DOI: 10.1128/mbio.00039-22

Abstract: Mucin glycoproteins are a major component that contributes to the complexity of the female reproductive tract (FRT). Group B Streptococcus (GBS) is present in the FRT of 25–30% of healthy women, but during pregnancy can… read more here.

Keywords: colonization; frt; gbs; mucin ... See more keywords
Photo from wikipedia

Interaction between the promoter MUC5B polymorphism and mucin expression: is there a difference according to ILD subtype?

Sign Up to like & get
recommendations! Published in 2020 at "Thorax"

DOI: 10.1136/thoraxjnl-2020-214579

Abstract: The MUC5B promoter variant rs35705950 is associated with idiopathic pulmonary fibrosis (IPF). MUC5B glycoprotein is overexpressed in IPF lungs. We examined immunohistochemical expression of MUC5B in different interstitial lung disease patterns according to rs35705950 T-allele… read more here.

Keywords: difference; muc5b; interaction promoter; promoter muc5b ... See more keywords

The Mucin Gene MUC5B Is Required for Normal Lung Function

Sign Up to like & get
recommendations! Published in 2022 at "American Journal of Respiratory and Critical Care Medicine"

DOI: 10.1164/rccm.202201-0064ed

Abstract: Airways have a mucus lining that protects the lungs from the deleterious effects of exposure to inhaled particles, pathogens, and gases. Airway mucus is a gel in which the polymer network consists of heavily glycosylated… read more here.

Keywords: mucus gel; lung; pathology; airway mucus ... See more keywords

Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules.

Sign Up to like & get
recommendations! Published in 2022 at "American journal of respiratory and critical care medicine"

DOI: 10.1164/rccm.202202-0309oc

Abstract: RATIONALE MUC5AC and MUC5B are the predominant secreted polymeric mucins in mammalian airways. They contribute differently to the pathogenesis of various muco-obstructive and interstitial lung diseases, and their genes are separately regulated, but whether they… read more here.

Keywords: muc5b variably; muc5ac muc5b; secretory granules; separate secretory ... See more keywords

Epithelial ER Stress Enhances the Risk of Muc5b Associated Lung Fibrosis.

Sign Up to like & get
recommendations! Published in 2022 at "American journal of respiratory cell and molecular biology"

DOI: 10.1165/rcmb.2022-0252oc

Abstract: The gain-of-function minor allele of the MUC5B promoter (rs35705950) is the strongest risk factor for idiopathic pulmonary fibrosis (IPF), a devastating fibrotic lung disease that leads to progressive respiratory failure in adults. We have previously… read more here.

Keywords: stress; lung fibrosis; mice; muc5b ... See more keywords

The MUC5B promoter polymorphism is associated with specific interstitial lung abnormality subtypes

Sign Up to like & get
recommendations! Published in 2017 at "European Respiratory Journal"

DOI: 10.1183/13993003.00537-2017

Abstract: The MUC5B promoter polymorphism (rs35705950) has been associated with interstitial lung abnormalities (ILA) in white participants from the general population; whether these findings are replicated and influenced by the ILA subtype is not known. We… read more here.

Keywords: muc5b promoter; promoter polymorphism; muc5b genotype; muc5b ... See more keywords

Co-culture of human AT2 cells with fibroblasts reveals a MUC5B phenotype: insights from an organoid model

Sign Up to like & get
recommendations! Published in 2024 at "Molecular Medicine"

DOI: 10.1186/s10020-024-00990-w

Abstract: Impaired interaction of fibroblasts with pneumocytes contributes to the progression of chronic lung disease such as idiopathic pulmonary fibrosis (IPF). Mucin 5B (MUC5B) is associated with IPF. Here we analyzed the interaction of primary fibroblasts… read more here.

Keywords: culture; at2 cells; culture human; muc5b ... See more keywords

COVID-19 Survivor Patients Carrying the Rs35705950 Risk Allele in MUC5B Have Higher Plasma Levels of Mucin 5B

Sign Up to like & get
recommendations! Published in 2022 at "Current Issues in Molecular Biology"

DOI: 10.3390/cimb44080226

Abstract: Background: Genetic susceptibility to infectious diseases is partly due to the variation in the human genome, and COVID-19 is not the exception. This study aimed to identify whether risk alleles of known genes linked with… read more here.

Keywords: risk allele; levels mucin; plasma; risk ... See more keywords