The minor T allele of the MUC5B promoter rs35705950 associated with susceptibility to idiopathic pulmonary fibrosis: a meta-analysis
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-03533-z
Abstract: MUC5B promoter rs35705950 T/G gene polymorphism has been associated with the risk of IPF, but the influence of this relationship varies among different populations. In the past 2 years, there were new clinical studies with… read more here.
Keywords: analysis; promoter rs35705950; population; minor allele ... See more keywords
Associations of the MUC5B Promoter Variant with Timing of Interstitial Lung Disease and Rheumatoid Arthritis Onset.
Sign Up to like & getrecommendations! Published in 2022 at "Rheumatology"
DOI: 10.1093/rheumatology/keac152
Abstract: OBJECTIVE To investigate the associations of the common MUC5B promoter variant with timing of RA-associated interstitial lung disease (RA-ILD) and RA onset. METHODS We identified patients with RA meeting 2010 ACR/EULAR criteria and available genotype… read more here.
Keywords: muc5b promoter; disease; promoter variant; lung ... See more keywords
The Idiopathic Pulmonary Fibrosis-Associated Single Nucleotide Polymorphism RS35705950 Is Transcribed in a MUC5B Promoter Associated Long Non-Coding RNA (AC061979.1)
Sign Up to like & getrecommendations! Published in 2022 at "Non-Coding RNA"
DOI: 10.1101/2022.01.18.476727
Abstract: LncRNAs are involved in regulatory processes in the human genome, including gene expression. The rs35705950 SNP, previously associated with IPF, overlaps the recently annotated lncRNA AC061979.1, a 1,712 nucleotide transcript located within the MUC5B promoter… read more here.
Keywords: non coding; expression; muc5b promoter; rs35705950 ... See more keywords
OP0284 Muc5b promoter variant rs35705950 is a risk factor for rheumatoid arthritis – interstitial lung disease
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.4727
Abstract: Background Rheumatoid arthritis–associated interstitial lung disease (RA-ILD) and idiopathic pulmonary fibrosis (IPF) share phenotypic similarities. The gain-of-function MUC5B promoter variant rs35705950 is the strongest risk factor for development of IPF Objectives We hypothesised that rs35705950… read more here.
Keywords: promoter variant; risk; muc5b promoter;
Association between acute respiratory disease events and the MUC5B promoter polymorphism in smokers
Sign Up to like & getrecommendations! Published in 2018 at "Thorax"
DOI: 10.1136/thoraxjnl-2017-211208
Abstract: A single-nucleotide polymorphism (rs35705950) in the mucin 5B (MUC5B) gene promoter is associated with pulmonary fibrosis and interstitial features on chest CT but may also have beneficial effects. In non-Hispanic whites in the COPDGene cohort… read more here.
Keywords: respiratory disease; promoter polymorphism; acute respiratory; polymorphism ... See more keywords
MUC5B promoter variant: genomic fingerprint for early identification of undiagnosed pulmonary fibrosis
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DOI: 10.1136/thoraxjnl-2019-214061
Abstract: The rising prevalence of pulmonary fibrosis and its attendant morbidity and mortality burden have spurred a renewed interest in the search for radiographical biomarkers predictive of early and clinically inconspicuous disease.1 The pressing need to… read more here.
Keywords: fibrosis; promoter variant; pulmonary fibrosis; variant genomic ... See more keywords
The MUC5B promoter polymorphism is associated with specific interstitial lung abnormality subtypes
Sign Up to like & getrecommendations! Published in 2017 at "European Respiratory Journal"
DOI: 10.1183/13993003.00537-2017
Abstract: The MUC5B promoter polymorphism (rs35705950) has been associated with interstitial lung abnormalities (ILA) in white participants from the general population; whether these findings are replicated and influenced by the ILA subtype is not known. We… read more here.
Keywords: muc5b promoter; promoter polymorphism; muc5b genotype; muc5b ... See more keywords