Modulating Copper(II) Coordination and Antimicrobial Activity: Effects of d-Amino Acid Substitution and Retro-Inverso Modification in Human Saliva MUC7 Peptide
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DOI: 10.1021/acs.inorgchem.5c00438
Abstract: Fragments of MUC7, a salivary protein involved in nonimmune defense, arise from proteolytic cleavage in saliva and exhibit antimicrobial properties. However, their therapeutic use is limited by low stability due to further degradation. To address… read more here.
Keywords: antimicrobial activity; chemistry; retro inverso; muc7 ... See more keywords
Streptococcus oralis Employs Multiple Mechanisms of Salivary Mucin Binding That Differ Between Strains
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.889711
Abstract: Streptococcus oralis is an oral commensal and opportunistic pathogen that can enter the bloodstream and cause bacteremia and infective endocarditis. Here, we investigated the mechanisms of S. oralis binding to oral mucins using clinical isolates,… read more here.
Keywords: sag; oralis binding; streptococcus oralis; muc7 ... See more keywords