Mucosomes: Intrinsically Mucoadhesive Glycosylated Mucin Nanoparticles as Multi‐Drug Delivery Platform
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202200340
Abstract: Mucus is a complex barrier for pharmacological treatments and overcoming it is one of the major challenges faced during transmucosal drug delivery. To tackle this issue, a novel class of glycosylated nanoparticles, named “mucosomes,” which… read more here.
Keywords: mucosomes intrinsically; mucin; intrinsically mucoadhesive; drug delivery ... See more keywords
Mucin‐Like Glycoproteins Modulate Interfacial Properties of a Mimetic Ocular Epithelial Surface
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Science"
DOI: 10.1002/advs.202100841
Abstract: Abstract Dry eye disease (DED) has high personal and societal costs, but its pathology remains elusive due to intertwined biophysical and biochemical processes at the ocular surface. Specifically, mucin deficiency is reported in a subset… read more here.
Keywords: interfacial properties; mucin; surface; mucin like ... See more keywords
Stable recombinant production of codon‐scrambled lubricin and mucin in human cells
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26940
Abstract: Widespread therapeutic and commercial interest in recombinant mucin technology has emerged due to the unique ability of mucin glycoproteins to hydrate, protect, and lubricate biological surfaces. However, recombinant production of the large, highly repetitive domains… read more here.
Keywords: production; mucin; recombinant production; stable recombinant ... See more keywords
Elevated MUC1 and MUC5AC mucin protein levels in airway mucus of critical ill COVID‐19 Patients
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Medical Virology"
DOI: 10.1002/jmv.26406
Abstract: Abstract Coronavirus disease 2019 (COVID‐19) patients exhibit a spectrum of respiratory symptoms like cough and dyspnea1‐3. Airway mucus is an adhesive viscoelastic gel composed mostly of high‐molecular weight mucous glycoproteins and water, which is important… read more here.
Keywords: covid patients; elevated muc1; mucin; muc1 muc5ac ... See more keywords
A bio-synthetic hybrid hydrogel formed under physiological conditions consisting of mucin and a synthetic polymer carrying boronic acid.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202200055
Abstract: Mucin-containing bio-synthetic hybrid hydrogel is successfully formed under physiological conditions upon mixing aqueous solutions of native mucin and synthetic polymers carrying boronic acids. The mechanical properties and stability of the hydrogel in physiological solutions, e.g.,… read more here.
Keywords: mucin; bio synthetic; boronic acid; hybrid hydrogel ... See more keywords
Nutrient-specific Proteomic Analysis of the Mucin Degrading Bacterium Akkermansia muciniphila.
Sign Up to like & getrecommendations! Published in 2021 at "Proteomics"
DOI: 10.1002/pmic.202100125
Abstract: Akkermansia muciniphila is a prominent mucin-degrading bacterium that acts as a keystone species in regulating the human gut microbiota. Despite recently increasing research into this bacterium and its relevance to human health, a high-resolution database… read more here.
Keywords: bacterium; degrading bacterium; mucin; akkermansia muciniphila ... See more keywords
Immunoresolvent Resolvin D1 Maintains the Health of the Ocular Surface.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-21735-8_3
Abstract: The present review focuses on the role of one of the D-series resolvins (Rv) RvD1 in the regulation of conjunctival goblet cell secretion and its role in ocular surface health. RvD1 is the most thoroughly… read more here.
Keywords: secretion; ocular surface; mucin; surface ... See more keywords
Pseudomyxoma Peritonei: Case Report and Literature Review
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Gastrointestinal Cancer"
DOI: 10.1007/s12029-018-00192-8
Abstract: Pseudomyxoma peritonei (PMP) is a disorder characterized by an intra-abdominal accumulation of mucin secondary to the growth of neoplastic mucin-secreting cells on peritoneal surfaces [1, 2]. PMP is a rare condition with an estimated incidence… read more here.
Keywords: pseudomyxoma; mucinous adenocarcinoma; pseudomyxoma peritonei; high grade ... See more keywords
Silicon nanodot-based aptasensor for fluorescence turn-on detection of mucin 1 and targeted cancer cell imaging.
Sign Up to like & getrecommendations! Published in 2018 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2018.06.032
Abstract: We report herein a new dual-color fluorescent aptasensor for detection of tumor marker mucin 1 (MUC1) and targeted imaging of MCF-7 cancer cells based on the specific interaction between MUC1 and its aptamer S2.2. The… read more here.
Keywords: detection; mucin; fluorescence; muc1 ... See more keywords
Assembly Mechanism of Mucin and von Willebrand Factor Polymers
Sign Up to like & getrecommendations! Published in 2020 at "Cell"
DOI: 10.1016/j.cell.2020.09.021
Abstract: Summary The respiratory and intestinal tracts are exposed to physical and biological hazards accompanying the intake of air and food. Likewise, the vasculature is threatened by inflammation and trauma. Mucin glycoproteins and the related von… read more here.
Keywords: assembly mechanism; von willebrand; mucin; willebrand factor ... See more keywords
Rheological investigations of beta glucan functionality: Interactions with mucin
Sign Up to like & getrecommendations! Published in 2019 at "Food Hydrocolloids"
DOI: 10.1016/j.foodhyd.2018.07.049
Abstract: Abstract The shear and extensional rheology of β-glucan and mucin mixtures have been studied as to probe the functionality-related thickening effects of consumed β-glucan during food digestion. Mucins, the main viscosity-inducing components of oral and… read more here.
Keywords: shear extensional; mucin; functionality; viscosity ... See more keywords