In vitro synthesis of mucin-type O-glycans using saccharide primers comprising GalNAc-Ser and GalNAc-Thr residues.
Sign Up to like & getrecommendations! Published in 2021 at "Carbohydrate research"
DOI: 10.1016/j.carres.2021.108495
Abstract: Mucin-type O-glycosylation of serine or threonine residue in proteins is known to be one of the major post-translational modifications. In this study, two novel alkyl glycosides, Nα-lauryl-O-(2-acetamido-2-deoxy-α-d-galactopyranosyl)-l-serineamide (GalNAc-Ser-C12) and Nα-lauryl-O-(2-acetamido-2-deoxy-α-d-galactopyranosyl)-l-threonineamide (GalNAc-Thr-C12) were synthesized as saccharide… read more here.
Keywords: galnac; galnac ser; saccharide primers; mucin type ... See more keywords
Hericium erinaceus isolectins recognize mucin-type O-glycans as tumor-associated carbohydrate antigens on the surface of K562 human leukemia cells.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.08.115
Abstract: In Hericium erinaceus mushroom fruiting body, two different lectin groups, HEL1 and HEL2, were identified by using peptide mass fingerprinting based on customized protein sequence databases derived from RNA-Seq data. The HEL2 group included four… read more here.
Keywords: associated carbohydrate; tumor associated; mucin type; type glycans ... See more keywords
Classification of Mucin-Type O-Glycopeptides Using Higher-Energy Collisional Dissociation in Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.0c01218
Abstract: Changes in mucin-type O-glycosylation of human proteins affect protein function, immune response, and cancer progression. As O-glycoproteins are characterized by microheterogeneity of diverse O-glycans with no conserved sequence and macroheterogeneity of multiple glycosylation sites on… read more here.
Keywords: extended core; mucin types; mucin; mucin type ... See more keywords
Mucin-type O-glycosylation controls pluripotency in mouse embryonic stem cells via Wnt receptor endocytosis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cell Science"
DOI: 10.1242/jcs.245845
Abstract: ABSTRACT Mouse embryonic stem cells (ESCs) can differentiate into a range of cell types during development, and this pluripotency is regulated by various extrinsic and intrinsic factors. Mucin-type O-glycosylation has been suggested to be a… read more here.
Keywords: pluripotency; mucin type; type glycosylation; mouse embryonic ... See more keywords
The GalNAc-T Activation Pathway (GALA) is not a general mechanism for regulating mucin-type O-glycosylation
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0179241
Abstract: Mucin-type O-glycosylation is initiated by the UDP-GalNAc polypeptide:N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. Their activity results in the GalNAc α1-O-Thr/Ser structure, termed the Tn antigen, which is further decorated with additional sugars. In neoplastic cells, the… read more here.
Keywords: golgi complex; mechanism; mucin type; type glycosylation ... See more keywords
Mucin-type sialyl-Tn antigen is associated with PD-L1 expression and predicts poor clinical prognosis in breast cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Gland surgery"
DOI: 10.21037/gs-21-83
Abstract: Background A recent study showed that mucin-type sialylated O-linked glycans could induce the increased expression of PD-L1 via binding to Siglec receptors. However, the relationship between the expression of the mucin-type sialyl-Tn antigen (sTn) and… read more here.
Keywords: stn expression; mucin type; type sialyl; expression ... See more keywords