Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease
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DOI: 10.1038/s41467-021-26777-9
Abstract: Lung diseases, such as cystic fibrosis and COPD, are characterized by mucus obstruction and chronic airway inflammation, but their mechanistic link remains poorly understood. Here, we focus on the function of the mucostatic airway microenvironment… read more here.
Keywords: disease; obstructive lung; muco obstructive; epigenetic reprogramming ... See more keywords
Lack of Kcnn4 improves mucociliary clearance in muco-obstructive lung disease
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DOI: 10.1172/jci.insight.140076
Abstract: Airway mucociliary clearance (MCC) is the main mechanism of lung defense keeping airways free of infection and mucus obstruction. Airway surface liquid volume, ciliary beating, and mucus are central for proper MCC and critically regulated… read more here.
Keywords: absorption; kcnn4; obstructive lung; muco obstructive ... See more keywords