Dual charged folate labelled chitosan nanogels with enhanced mucoadhesion capacity for targeted drug delivery
Sign Up to like & getrecommendations! Published in 2020 at "European Polymer Journal"
DOI: 10.1016/j.eurpolymj.2020.109847
Abstract: Abstract Nanometric gel particles (CsSH/PEGBCOOH) were successfully synthesized through water in oil (W/O) emulsion by the covalent cross–linking between the primary amines of thiolated chitosan (CsSH) and the dicarboxylic poly(ethylene glycol) (PEG) derivative as cross–linker… read more here.
Keywords: folate labelled; charged folate; mucoadhesion; dual charged ... See more keywords
Role of Physicochemical Properties of Some Grades of Hydroxypropyl Methylcellulose on In Vitro Mucoadhesion.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2021.121218
Abstract: Relationships between physicochemical properties of hydroxypropyl methylcellulose (HPMC) compacts and their in vitro mucoadhesive performances were investigated in this study. Some commercial grades of HPMC (K3, E3, E5, E50, K4M, E4M and K15M) were prepared… read more here.
Keywords: hpmc compacts; vitro mucoadhesive; hydroxypropyl methylcellulose; physicochemical properties ... See more keywords
Boronic Acid-Tethered Silk Fibroin for pH-Dependent Mucoadhesion.
Sign Up to like & getrecommendations! Published in 2023 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c01349
Abstract: Mucus lines all surfaces of the human body not covered by skin and provides lubrication, hydration, and protection. The properties of mucus are influenced by changes in pH that may occur due to physiological conditions… read more here.
Keywords: acid tethered; silk fibroin; boronic acid; acid ... See more keywords
Mucoadhesive drug delivery systems: a promising non-invasive approach to bioavailability enhancement. Part I: biophysical considerations
Sign Up to like & getrecommendations! Published in 2023 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2023.2181331
Abstract: ABSTRACT Introduction Mucoadhesive drug delivery systems (MDDS) are specifically designed to interact and bind to the mucosal layer for localized, prolonged, and/or targeted drug delivery. Over the past 4 decades, different sites have been explored… read more here.
Keywords: mucoadhesive drug; anatomy; drug delivery; mucoadhesion ... See more keywords
MUCO-DIS: a New AFM-Based Nanoscale Dissolution Technique
Sign Up to like & getrecommendations! Published in 2020 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-020-01697-x
Abstract: Mucoadhesion-based drug delivery systems have recently gained interest because of their bio-adhesion capability, which results in enhanced residence time leading to prolonged duration of action with the mucosal surface, potentially improving compliance and convenience. Mucoadhesion… read more here.
Keywords: topography; technique; surface; mucoadhesion ... See more keywords
Triborheological Analysis of Reconstituted Gastrointestinal Mucus/Chitosan:TPP Nanoparticles System to Study Mucoadhesion Phenomenon under Different pH Conditions
Sign Up to like & getrecommendations! Published in 2022 at "Polymers"
DOI: 10.3390/polym14224978
Abstract: Polymeric nanoparticles have attracted much attention as pharmaceutical delivery vehicles to prolong residence time and enhance the bioavailability of therapeutic molecules through the mucoadhesive phenomenon. In this study, chitosan:TPP nanoparticles were synthetized using the ionic… read more here.
Keywords: tpp nanoparticles; chitosan tpp; tpp; mucoadhesion ... See more keywords