Airway obstruction in respiratory viral infections due to impaired mucociliary clearance.
Sign Up to like & getrecommendations! Published in 2023 at "International journal for numerical methods in biomedical engineering"
DOI: 10.1002/cnm.3707
Abstract: Respiratory viral infections, such as SARS-CoV-2 or influenza, can lead to impaired mucociliary clearance in the bronchial tree due to increased mucus viscosity and its hyper-secretion. We develop in this work a mathematical model to… read more here.
Keywords: viral infections; respiratory viral; mucus; impaired mucociliary ... See more keywords
Impairment of nasal mucociliary clearance time in wood industry workers
Sign Up to like & getrecommendations! Published in 2019 at "European Archives of Oto-Rhino-Laryngology"
DOI: 10.1007/s00405-019-05729-6
Abstract: Purpose The aim of this study is to investigate the effect of wood dust on nasal mucociliary clearance time in wood industry workers. Moreover, the correlation between duration of exposure to wood dust and nasal mucociliary clearance time will be… read more here.
Keywords: wood industry; mucociliary clearance; wood; clearance time ... See more keywords
Mutations in TP73 cause impaired mucociliary clearance and lissencephaly.
Sign Up to like & getrecommendations! Published in 2021 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2021.05.002
Abstract: TP73 belongs to the TP53 family of transcription factors and has therefore been well studied in cancer research. Studies in mice, however, have revealed non-oncogenic activities related to multiciliogenesis. Utilizing whole-exome sequencing analysis in a… read more here.
Keywords: tp73 cause; lissencephaly; mucociliary clearance; microscopy ... See more keywords
Antiviral drug screening by assessing epithelial functions and innate immune responses in human 3D airway epithelium model
Sign Up to like & getrecommendations! Published in 2018 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2018.06.007
Abstract: ABSTRACT Respiratory viral infections cause mild to severe diseases, such as common cold, bronchiolitis and pneumonia and are associated with substantial burden for society. To test new molecules for shortening, alleviating the diseases or to… read more here.
Keywords: epithelial functions; antiviral drug; antiviral drugs; mucociliary clearance ... See more keywords
Mucociliary clearance differs in mild asthma by levels of Type-2 inflammation.
Sign Up to like & getrecommendations! Published in 2021 at "Chest"
DOI: 10.1016/j.chest.2021.05.013
Abstract: BACKGROUND While mucus plugging is a well reported feature of asthma, it is unknown whether asthma and type-2 inflammation affect mucociliary clearance (MCC). RESEARCH QUESTION Does type 2 inflammation influence mucus clearance rates in mild… read more here.
Keywords: mcc; clearance differs; type inflammation; mucociliary clearance ... See more keywords
Ineffective cough and mechanical mucociliary clearance techniques.
Sign Up to like & getrecommendations! Published in 2018 at "Medicina Intensiva"
DOI: 10.1016/j.medine.2017.12.005
Abstract: Abstract Cough is a fundamental defense mechanism for keeping the airway free of foreign elements. Life-threatening situations may arise when cough proves ineffective as a result of muscle weakness or altered mucociliary function. When a… read more here.
Keywords: ineffective cough; clearance techniques; mechanical mucociliary; mucociliary clearance ... See more keywords
Characterizing mucociliary clearance in young children with cystic fibrosis
Sign Up to like & getrecommendations! Published in 2021 at "Pediatric Research"
DOI: 10.1038/s41390-021-01453-2
Abstract: This research characterized mucociliary clearance (MCC) in young children with cystic fibrosis (CF). Fourteen children (5–7 years old) with CF underwent: two baseline MCC measurements (Visits 1 and 2); one MCC measurement approximately 1 year… read more here.
Keywords: cystic fibrosis; mcc; mucociliary clearance; pathology ... See more keywords
Mucociliary Clearance in Mice Measured by Tracking Trans-tracheal Fluorescence of Nasally Aerosolized Beads
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-33053-2
Abstract: Mucociliary clearance (MCC) is the first line of defense in clearing airways. In genetically engineered mice, each component of this system (ciliary beat, mucus, airway surface hydration) can be studied separately to determine its contribution… read more here.
Keywords: mcc; trans tracheal; mucociliary clearance; mice ... See more keywords
Elastic mucus strands impair mucociliary clearance in cystic fibrosis pigs
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2121731119
Abstract: Significance In many lung diseases, increased amounts of and/or abnormal mucus impair mucociliary clearance, a key defense against inhaled and aspirated material. Submucosal glands lining cartilaginous airways secrete mucus strands that are pulled by cilia… read more here.
Keywords: mucus; impair mucociliary; mucus strands; mucociliary clearance ... See more keywords
The effect of COVID-19 on nasal mucociliary clearance
Sign Up to like & getrecommendations! Published in 2022 at "Acta Oto-Laryngologica"
DOI: 10.1080/00016489.2022.2048072
Abstract: Abstract Background The impacts of coronavirus disease-2019 (COVID-19) on nasal mucociliary clearance (MCC) have shown conflicting results. Objectives The aim of this study was to determine whether COVID-19 infections affect nasal mucociliary activity using the… read more here.
Keywords: nasal mcc; nasal mucociliary; covid; covid nasal ... See more keywords
Impact of Allergic Rhinitis on Nasal Mucociliary Clearance Time in Children
Sign Up to like & getrecommendations! Published in 2019 at "International Archives of Allergy and Immunology"
DOI: 10.1159/000499740
Abstract: Background: Mucociliary clearance is one of the most important protective functions of the airway. Previous studies, checking the influence of allergic rhinitis (AR) on mucociliary clearance time (MCT), were made on small patient groups and… read more here.
Keywords: allergic rhinitis; clearance time; mucociliary clearance; clearance ... See more keywords