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   Articles with "mucosal associated" as a keyword



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OMIP 082: A 25‐color phenotyping to define human innate lymphoid cells, natural killer cells, mucosal‐associated invariant T cells, and γδ T cells from freshly isolated human intestinal tissue

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recommendations! Published in 2022 at "Cytometry Part A"

DOI: 10.1002/cyto.a.24529

Abstract: We developed a 25‐color flow cytometry panel to comprehensively interrogate innate lymphoid cells (ILC), mucosal‐associated invariant T (MAIT) cells, natural killer (NK) cells and γδ T cells in human tissues. The ability to isolate and… read more here.

Keywords: cells natural; mucosal associated; associated invariant; innate lymphoid ... See more keywords
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Th1 bias of liver mucosal‐associated invariant T cells promotes hepatic gluconeogenesis in type 2 diabetes mellitus

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recommendations! Published in 2023 at "Diabetes/Metabolism Research and Reviews"

DOI: 10.1002/dmrr.3620

Abstract: It is acknowledged that aberrant liver immunity contributes to the development of type 2 diabetes mellitus (T2DM). Mucosal‐associated invariant T (MAIT) cells, an innate‐like T‐cell subset, are enriched in the human liver. Nevertheless, the characterisation… read more here.

Keywords: liver; mucosal associated; associated invariant; type diabetes ... See more keywords
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TCR- or Cytokine-Activated CD8+ Mucosal-Associated Invariant T Cells Are Rapid Polyfunctional Effectors That Can Coordinate Immune Responses.

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recommendations! Published in 2019 at "Cell reports"

DOI: 10.1016/j.celrep.2019.08.054

Abstract: Mucosal-associated invariant T (MAIT) cells can be activated via either their T cell receptor (TCR), which recognizes MR1-bound pyrimidines derived from microbial riboflavin biosynthesis, or via cytokines. These two modes of activation may act in concert… read more here.

Keywords: tcr cytokine; mait cells; associated invariant; immune responses ... See more keywords
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Mucosal-Associated Invariant T Cells Redistribute to the Peritoneal Cavity During Spontaneous Bacterial Peritonitis and Contribute to Peritoneal Inflammation

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recommendations! Published in 2020 at "Cellular and Molecular Gastroenterology and Hepatology"

DOI: 10.1016/j.jcmgh.2020.01.003

Abstract: Background & Aims Mucosal-associated invariant T (MAIT) cells are depleted from blood in patients with advanced liver disease and show features of immune dysfunction. Because circulating MAIT cells differ from organ-resident MAIT cells, we aimed… read more here.

Keywords: associated invariant; mait cells; peritoneal mait; mait ... See more keywords
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DNA-MVA-protein vaccination of rhesus macaques induces HIV-specific immunity in mucosal-associated lymph nodes and functional antibodies

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recommendations! Published in 2017 at "Vaccine"

DOI: 10.1016/j.vaccine.2016.12.060

Abstract: Successful future HIV vaccines are expected to generate an effective cellular and humoral response against the virus in both the peripheral blood and mucosal compartments. We previously reported the development of DNA-C and MVA-C vaccines… read more here.

Keywords: associated lymph; mucosal; mucosal associated; rhesus macaques ... See more keywords
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MR1 Restricted Mucosal-Associated Invariant T (MAIT) Cells Respond to Mycobacterial Vaccination and Infection in Nonhuman Primates

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recommendations! Published in 2017 at "Mucosal immunology"

DOI: 10.1038/mi.2016.91

Abstract: Studies on mucosal-associated invariant T cells (MAITs) in nonhuman primates (NHP), a physiologically relevant model of human immunity, are handicapped due to a lack of macaque MAIT-specific reagents. Here we show that while MR1 ligand-contact… read more here.

Keywords: associated invariant; mr1; mait; mucosal associated ... See more keywords
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Mucosal-associated invariant T cells and disease

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recommendations! Published in 2019 at "Nature Reviews Immunology"

DOI: 10.1038/s41577-019-0191-y

Abstract: Mucosal-associated invariant T (MAIT) cells are unique innate-like T cells that bridge innate and adaptive immunity. They are activated by conserved bacterial ligands derived from vitamin B biosynthesis and have important roles in defence against… read more here.

Keywords: associated invariant; cells disease; mucosal associated; invariant cells ... See more keywords
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Agonistic or antagonistic mucosal-associated invariant T (MAIT) cell activity is determined by the 6-alkylamino substituent on uracil MR1 ligands.

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recommendations! Published in 2020 at "Chemical communications"

DOI: 10.1039/d0cc00247j

Abstract: Mucosal-associated invariant T (MAIT) are a subset of innate-like T cells that are activated by uracil ligands presented by MR1. For the first time, we demonstrate that changes to the 6-aminoalkyl chain on uracil agonist… read more here.

Keywords: mait cell; associated invariant; mait; mucosal associated ... See more keywords
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Human mucosal-associated invariant T cells respond to Mucorales species in a MR1-dependent manner.

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recommendations! Published in 2020 at "Medical mycology"

DOI: 10.1093/mmy/myaa103

Abstract: Activation of mucosal-associated invariant T cells (MAIT cells) by certain bacteria, viruses, and yeast is well studied, but the activation potential of filamentous moulds from the order Mucorales is not known. Here, we show a… read more here.

Keywords: mucorales species; associated invariant; mucosal associated; activation ... See more keywords
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Persistent deficiency of mucosal-associated invariant T cells during dermatomyositis.

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recommendations! Published in 2019 at "Rheumatology"

DOI: 10.1093/rheumatology/kez564

Abstract: OBJECTIVES Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that are important for antibacterial immunity and may have regulatory roles. MAIT cells are decreased during SLE. However, their frequencies and phenotype have not been investigated… read more here.

Keywords: healthy controls; mait cells; associated invariant; mait ... See more keywords
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Mucosal-associated Lymphoid Tissue (MALT) Lymphoma in Association With Pediatric Primary Sjogren Syndrome: 2 Cases and Review

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recommendations! Published in 2019 at "Journal of Pediatric Hematology/Oncology"

DOI: 10.1097/mph.0000000000001321

Abstract: Mucosal-associated lymphoid tissue (MALT) lymphoma is rare in the pediatric population, but primary Sjogren syndrome is a well-established risk factor for this malignancy. This report describes 2 cases of MALT lymphoma in children with Sjogren… read more here.

Keywords: malt lymphoma; oncology; mucosal associated; sjogren syndrome ... See more keywords