Articles with "mucosal barrier" as a keyword



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MicroRNA‐9a‐5p inhibits mucosal barrier injury in inflammatory bowel disease

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Published in 2022 at "Journal of Biochemical and Molecular Toxicology"

DOI: 10.1002/jbt.23131

Abstract: Our previous research found that FOXO1 aggravates the mucosal barrier injury in inflammatory bowel disease (IBD) by regulating TLR4/MD2 signaling. In this study, we further reveal the mechanism of action whereby miRNA‐9a‐5p inhibits the mucosal… read more here.

Keywords: mucosal barrier; barrier injury; disease; inflammatory ... See more keywords
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Autophagy Strengthens Intestinal Mucosal Barrier by Attenuating Oxidative Stress in Severe Acute Pancreatitis

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Published in 2018 at "Digestive Diseases and Sciences"

DOI: 10.1007/s10620-018-4962-2

Abstract: BackgroundIntestinal mucosal barrier dysfunction can be caused by severe acute pancreatitis (SAP). It is normally associated with changes to mucosal autophagy and oxidative stress.ObjectiveThe aim of this study was to investigate the correlation between autophagy… read more here.

Keywords: mucosal barrier; group; oxidative stress;
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Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity

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Published in 2020 at "Cell"

DOI: 10.1016/j.cell.2019.12.016

Abstract: Mucosal barrier immunity is essential for the maintenance of the commensal microflora and combating invasive bacterial infection. Although immune and epithelial cells are thought to be the canonical orchestrators of this complex equilibrium, here, we… read more here.

Keywords: immunity; nervous system; mucosal barrier; enteric nervous ... See more keywords
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Activation of IGF-1/IGFBP-3 signaling by berberine improves intestinal mucosal barrier of rats with acute endotoxemia.

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Published in 2018 at "Fitoterapia"

DOI: 10.1016/j.fitote.2017.11.012

Abstract: Insulin-like growth factor I (IGF-I) and binding protein 3 (IGFBP-3) play a role in the maintenance of gut mucosal barrier function. Nevertheless, IGF-I/IGFBP-3 and tight junction protein (TJP) expression in small intestinal mucosa are often… read more here.

Keywords: igfbp signaling; acute endotoxemia; igf; mucosal barrier ... See more keywords
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Konjac glucomannan polysaccharide and inulin oligosaccharide enhance the colonic mucosal barrier function and modulate gut-associated lymphoid tissue immunity in C57BL/6J mice

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Published in 2020 at "British Journal of Nutrition"

DOI: 10.1017/s000711451900285x

Abstract: Abstract Both konjac glucomannan (KGM) and inulin oligosaccharide have been shown to improve bowel function, but their effects on the mucosal barrier function and immunity are not fully understood. The aim of the present study… read more here.

Keywords: mucosal barrier; barrier function; immunity; inulin oligosaccharide ... See more keywords
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Partially Acid-Hydrolyzed Porphyran Improved Dextran Sulfate Sodium-Induced Acute Colitis by Modulation of Gut Microbiota and Enhancing the Mucosal Barrier.

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Published in 2023 at "Journal of agricultural and food chemistry"

DOI: 10.1021/acs.jafc.2c08564

Abstract: The pharmacological values of marine algal polysaccharides on gut health are being recognized in recent research. However, the protective effect of degraded polysaccharides from Porphyra haitanensis (PHP-D) on the colonic mucosal barrier damaged in ulcerative… read more here.

Keywords: mucosal barrier; gut microbiota; colitis; dextran sulfate ... See more keywords

Leptin alleviates intestinal mucosal barrier injury and inflammation in obese mice with acute pancreatitis

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Published in 2018 at "International Journal of Obesity"

DOI: 10.1038/s41366-018-0125-y

Abstract: Background/ObjectivesObesity is an independent risk factor for severe acute pancreatitis (AP). Leptin plays an important role in energy homeostasis. It has been reported that leptin might also participate in the regulation of the intestinal mucosal… read more here.

Keywords: acute pancreatitis; leptin; intestinal mucosal; mucosal barrier ... See more keywords
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Obesity Aggravates Acute Pancreatitis via Damaging Intestinal Mucosal Barrier and Changing Microbiota Composition in Rats

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Published in 2019 at "Scientific Reports"

DOI: 10.1038/s41598-018-36266-7

Abstract: Obesity may aggravate acute pancreatitis (AP) through damaging the intestinal mucosal barrier (IMB). The underlying mechanism remains unclear. This study was aimed to provide further data to clarify the mechanism. 48 rats were divided into… read more here.

Keywords: acute pancreatitis; fed rats; intestinal mucosal; mucosal barrier ... See more keywords
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GPR120 prevents colorectal adenocarcinoma progression by sustaining the mucosal barrier integrity

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Published in 2022 at "Scientific Reports"

DOI: 10.1038/s41598-021-03787-7

Abstract: GPR120 (encoded by FFAR4 gene) is a receptor for long chain fatty acids, activated by ω-3 Polyunsaturated Fatty Acids (PUFAs), and expressed in many cell types. Its role in the context of colorectal cancer (CRC)… read more here.

Keywords: mucosal barrier; gpr120; barrier integrity; progression ... See more keywords
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Berberine represses Wnt/β-catenin pathway activation via modulating the microRNA-103a-3p/Bromodomain-containing protein 4 axis, thereby refraining pyroptosis and reducing the intestinal mucosal barrier defect induced via colitis

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Published in 2022 at "Bioengineered"

DOI: 10.1080/21655979.2022.2047405

Abstract: ABSTRACT Intestinal barrier dysfunction is inflammatory bowel disease’s hallmark. Berberine (BBR) has manifested its anti-inflammatory properties in colitis. For exploring the molecular mechanism of BBR’s impacts on colitis, application of a dextran sodium sulfate-induced mouse… read more here.

Keywords: mucosal barrier; barrier; mir 103a; colitis ... See more keywords
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Toll-Like Receptor 9 Signaling Pathway Contributes to Intestinal Mucosal Barrier Injury in Mice With Severe Acute Pancreatitis

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Published in 2022 at "Pancreas"

DOI: 10.1097/mpa.0000000000002169

Abstract: Objectives The purpose of this study was to investigate the role and mechanism of toll-like receptor 9 (TLR9) in intestinal mucosal barrier injury in mice with severe acute pancreatitis (SAP). Methods The mice were randomly… read more here.

Keywords: mucosal barrier; toll like; intestinal mucosal; mice ... See more keywords