H2S‐Releasing Versatile Montmorillonite Nanoformulation Trilogically Renovates the Gut Microenvironment for Inflammatory Bowel Disease Modulation
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202308092
Abstract: Abnormal activation of the intestinal mucosal immune system, resulting from damage to the intestinal mucosal barrier and extensive invasion by pathogens, contributes to the pathogenesis of inflammatory bowel disease (IBD). Current first‐line treatments for IBD… read more here.
Keywords: dps mmt; bowel disease; nanoformulation; mucosal barrier ... See more keywords
MicroRNA‐9a‐5p inhibits mucosal barrier injury in inflammatory bowel disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23131
Abstract: Our previous research found that FOXO1 aggravates the mucosal barrier injury in inflammatory bowel disease (IBD) by regulating TLR4/MD2 signaling. In this study, we further reveal the mechanism of action whereby miRNA‐9a‐5p inhibits the mucosal… read more here.
Keywords: mucosal barrier; barrier injury; disease; inflammatory ... See more keywords
The role of the mucosal barrier system in maintaining gut symbiosis to prevent intestinal inflammation
Sign Up to like & getrecommendations! Published in 2024 at "Seminars in Immunopathology"
DOI: 10.1007/s00281-024-01026-5
Abstract: In the intestinal tract, where numerous intestinal bacteria reside, intestinal epithelial cells produce and release various antimicrobial molecules that form a complex barrier on the mucosal surface. These barrier molecules can be classified into two… read more here.
Keywords: mucosal; intestinal inflammation; barrier; mucosal barrier ... See more keywords
Autophagy Strengthens Intestinal Mucosal Barrier by Attenuating Oxidative Stress in Severe Acute Pancreatitis
Sign Up to like & getrecommendations! Published in 2018 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-018-4962-2
Abstract: BackgroundIntestinal mucosal barrier dysfunction can be caused by severe acute pancreatitis (SAP). It is normally associated with changes to mucosal autophagy and oxidative stress.ObjectiveThe aim of this study was to investigate the correlation between autophagy… read more here.
Keywords: mucosal barrier; group; oxidative stress;
Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity
Sign Up to like & getrecommendations! Published in 2020 at "Cell"
DOI: 10.1016/j.cell.2019.12.016
Abstract: Mucosal barrier immunity is essential for the maintenance of the commensal microflora and combating invasive bacterial infection. Although immune and epithelial cells are thought to be the canonical orchestrators of this complex equilibrium, here, we… read more here.
Keywords: immunity; nervous system; mucosal barrier; enteric nervous ... See more keywords
Activation of IGF-1/IGFBP-3 signaling by berberine improves intestinal mucosal barrier of rats with acute endotoxemia.
Sign Up to like & getrecommendations! Published in 2018 at "Fitoterapia"
DOI: 10.1016/j.fitote.2017.11.012
Abstract: Insulin-like growth factor I (IGF-I) and binding protein 3 (IGFBP-3) play a role in the maintenance of gut mucosal barrier function. Nevertheless, IGF-I/IGFBP-3 and tight junction protein (TJP) expression in small intestinal mucosa are often… read more here.
Keywords: igfbp signaling; acute endotoxemia; igf; mucosal barrier ... See more keywords
Konjac glucomannan polysaccharide and inulin oligosaccharide enhance the colonic mucosal barrier function and modulate gut-associated lymphoid tissue immunity in C57BL/6J mice
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Nutrition"
DOI: 10.1017/s000711451900285x
Abstract: Abstract Both konjac glucomannan (KGM) and inulin oligosaccharide have been shown to improve bowel function, but their effects on the mucosal barrier function and immunity are not fully understood. The aim of the present study… read more here.
Keywords: mucosal barrier; barrier function; immunity; inulin oligosaccharide ... See more keywords
Partially Acid-Hydrolyzed Porphyran Improved Dextran Sulfate Sodium-Induced Acute Colitis by Modulation of Gut Microbiota and Enhancing the Mucosal Barrier.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c08564
Abstract: The pharmacological values of marine algal polysaccharides on gut health are being recognized in recent research. However, the protective effect of degraded polysaccharides from Porphyra haitanensis (PHP-D) on the colonic mucosal barrier damaged in ulcerative… read more here.
Keywords: mucosal barrier; gut microbiota; colitis; dextran sulfate ... See more keywords
Leptin alleviates intestinal mucosal barrier injury and inflammation in obese mice with acute pancreatitis
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Obesity"
DOI: 10.1038/s41366-018-0125-y
Abstract: Background/ObjectivesObesity is an independent risk factor for severe acute pancreatitis (AP). Leptin plays an important role in energy homeostasis. It has been reported that leptin might also participate in the regulation of the intestinal mucosal… read more here.
Keywords: acute pancreatitis; leptin; intestinal mucosal; mucosal barrier ... See more keywords
Obesity Aggravates Acute Pancreatitis via Damaging Intestinal Mucosal Barrier and Changing Microbiota Composition in Rats
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DOI: 10.1038/s41598-018-36266-7
Abstract: Obesity may aggravate acute pancreatitis (AP) through damaging the intestinal mucosal barrier (IMB). The underlying mechanism remains unclear. This study was aimed to provide further data to clarify the mechanism. 48 rats were divided into… read more here.
Keywords: acute pancreatitis; fed rats; intestinal mucosal; mucosal barrier ... See more keywords
GPR120 prevents colorectal adenocarcinoma progression by sustaining the mucosal barrier integrity
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DOI: 10.1038/s41598-021-03787-7
Abstract: GPR120 (encoded by FFAR4 gene) is a receptor for long chain fatty acids, activated by ω-3 Polyunsaturated Fatty Acids (PUFAs), and expressed in many cell types. Its role in the context of colorectal cancer (CRC)… read more here.
Keywords: mucosal barrier; gpr120; barrier integrity; progression ... See more keywords