Is the APEX Score the Pinnacle of Predictive Scoring Systems of Disease Flare in Crohn’s Patients with Documented Mucosal Healing?
Sign Up to like & getrecommendations! Published in 2021 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-021-07154-4
Abstract: Crohn’s disease (CD) is a chronic relapsing immune-mediated disease affecting the gastrointestinal tract. Effective disease management is dependent on regularly assessing patients with CD for disease recurrence, which is defined according to clinical, radiographic, serologic,… read more here.
Keywords: sbce; small bowel; disease; mucosal healing ... See more keywords
Mechanism of Acupuncture and Moxibustion on Promoting Mucosal Healing in Ulcerative Colitis
Sign Up to like & getrecommendations! Published in 2022 at "Chinese Journal of Integrative Medicine"
DOI: 10.1007/s11655-022-3531-x
Abstract: The latest guideline about ulcerative colitis (UC) clinical practice stresses that mucosal healing, rather than anti-inflammation, is the main target in UC clinical management. Current mucosal dysfunction mainly closely relates to the endoscopic intestinal wall… read more here.
Keywords: acupuncture moxibustion; barrier; ulcerative colitis; moxibustion ... See more keywords
Transcriptome profiling of mouse colonic eosinophils reveals a key role for eosinophils in the induction of s100a8 and s100a9 in mucosal healing
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-07738-z
Abstract: Eosinophils are bone marrow-derived cells that have been largely implicated in Th2-associated diseases. Recent data highlights a key role for eosinophils in mucosal innate immune responses especially in the gastrointestinal (GI) tract, which is one… read more here.
Keywords: colonic eosinophils; mucosal healing; role eosinophils; key role ... See more keywords
Heat shock transcription factor 2 predicts mucosal healing and promotes mucosal repair of ulcerative colitis
Sign Up to like & getrecommendations! Published in 2020 at "Scandinavian Journal of Gastroenterology"
DOI: 10.1080/00365521.2020.1774924
Abstract: Abstract Background: Mucosal healing(MH) is a treatment goal in ulcerative colitis (UC). Our previous studies showed heat shock transcription factor 2 (HSF2) was positively correlated with the activity of UC and had anti-inflammatory potential in… read more here.
Keywords: heat shock; shock transcription; mucosal healing; transcription factor ... See more keywords
P380 Comparison of mucosal healing through segments of ileocolonic Crohn’s disease treated with biologics
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjab076.504
Abstract: Although major advances in Inflammatory bowel disease’s treatment have been observed, the response to the pharmacologic therapies is still unpredictable and highly variable. Mucosal healing (MH) is an important endpoint in Crohn’s disease patients undergoing… read more here.
Keywords: response; ileal colonic; disease; mucosal healing ... See more keywords
Accuracy of Diffusion-weighted Magnetic Resonance Imaging in Detecting Mucosal Healing and Treatment Response, and in Predicting Surgery, in Crohn’s Disease
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjy098
Abstract: Background and Aims The Nancy score is a luminal Crohn's disease [CD] activity index applied in diffusion-weighted magnetic resonance imaging [DW-MRI]. We assessed the accuracy of the Nancy score in detecting mucosal healing and treatment… read more here.
Keywords: score; mucosal healing; healing treatment; nancy score ... See more keywords
Infliximab Trough Levels Are Associated With Mucosal Healing During Maintenance Treatment With Infliximab in Paediatric Crohn’s Disease
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjy155
Abstract: Background and Aims Mucosal healing is an important treatment goal in Crohn's disease. We investigated the association between serum infliximab trough levels and mucosal healing, and the infliximab cut-off levels required for mucosal healing in… read more here.
Keywords: infliximab trough; trough levels; mucosal healing; crohn disease ... See more keywords
Higher Ustekinumab Levels in Maintenance Therapy are Associated with Greater Mucosal Healing and Mucosal Response in Crohn's Disease: An Experience of 2 IBD Centers.
Sign Up to like & getrecommendations! Published in 2023 at "Inflammatory bowel diseases"
DOI: 10.1093/ibd/izad073
Abstract: BACKGROUND Ustekinumab (UST), a human monoclonal antibody that binds the p40 subunit of interleukin 12 (IL-12) and IL-23, is licensed for induction and maintenance therapy of moderate to severe inflammatory bowel disease (IBD). To date,… read more here.
Keywords: mucosal response; mucosal healing; response; crohn disease ... See more keywords
Development and Validation of a Confocal Laser Endomicroscopy-Based Score for In Vivo Assessment of Mucosal Healing in Ulcerative Colitis Patients.
Sign Up to like & getrecommendations! Published in 2017 at "Inflammatory bowel diseases"
DOI: 10.1093/ibd/izx012
Abstract: Background Endoscopic monitoring is fundamental for evaluating the therapeutic response in IBD, but a validated endomicroscopic mucosal healing (MH) score is not available to date. However, confocal laser endomicroscopy (CLE) might define MH more precisely… read more here.
Keywords: confocal laser; laser endomicroscopy; mucosal healing; cle ... See more keywords
Separation of Dual Oxidase 2 and Lactoperoxidase Expression in Intestinal Crypts and Species Differences May Limit Hydrogen Peroxide Scavenging During Mucosal Healing in Mice and Humans.
Sign Up to like & getrecommendations! Published in 2017 at "Inflammatory bowel diseases"
DOI: 10.1093/ibd/izx024
Abstract: Background DUOX2 and DUOXA2 form the predominant H2O2-producing system in human colorectal mucosa. Inflammation, hypoxia, and 5-aminosalicylic acid increase H2O2 production, supporting innate defense and mucosal healing. Thiocyanate reacts with H2O2 in the presence of… read more here.
Keywords: intestinal crypts; mucosal; mucosal healing; h2o2 ... See more keywords
Early Mucosal Healing Predicts Favorable Outcomes in Patients With Moderate to Severe Ulcerative Colitis Treated With Golimumab: Data From the Real-life BE-SMART Cohort.
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DOI: 10.1093/ibd/izy219
Abstract: Background Golimumab (GOL) is registered for moderate to severely active ulcerative colitis (UC). Data on the use of GOL in daily clinical practice are limited. Currently, it is unclear which factors are predictive of a… read more here.
Keywords: week; term; colitis; mucosal healing ... See more keywords