Is the APEX Score the Pinnacle of Predictive Scoring Systems of Disease Flare in Crohn’s Patients with Documented Mucosal Healing?
Sign Up to like & getrecommendations! Published in 2021 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-021-07154-4
Abstract: Crohn’s disease (CD) is a chronic relapsing immune-mediated disease affecting the gastrointestinal tract. Effective disease management is dependent on regularly assessing patients with CD for disease recurrence, which is defined according to clinical, radiographic, serologic,… read more here.
Keywords: sbce; small bowel; disease; mucosal healing ... See more keywords
Mechanism of Acupuncture and Moxibustion on Promoting Mucosal Healing in Ulcerative Colitis
Sign Up to like & getrecommendations! Published in 2022 at "Chinese Journal of Integrative Medicine"
DOI: 10.1007/s11655-022-3531-x
Abstract: The latest guideline about ulcerative colitis (UC) clinical practice stresses that mucosal healing, rather than anti-inflammation, is the main target in UC clinical management. Current mucosal dysfunction mainly closely relates to the endoscopic intestinal wall… read more here.
Keywords: acupuncture moxibustion; barrier; ulcerative colitis; moxibustion ... See more keywords
Transcriptome profiling of mouse colonic eosinophils reveals a key role for eosinophils in the induction of s100a8 and s100a9 in mucosal healing
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DOI: 10.1038/s41598-017-07738-z
Abstract: Eosinophils are bone marrow-derived cells that have been largely implicated in Th2-associated diseases. Recent data highlights a key role for eosinophils in mucosal innate immune responses especially in the gastrointestinal (GI) tract, which is one… read more here.
Keywords: colonic eosinophils; mucosal healing; role eosinophils; key role ... See more keywords
CHRONOLOGICAL AGE INFLUENCES TREATMENT DECISION IN INFLAMMATORY BOWEL DISEASE: AN IBD QORUS COLLABORATIVE STUDY
Sign Up to like & getrecommendations! Published in 2024 at "Gastroenterology"
DOI: 10.1053/j.gastro.2023.11.257
Abstract: Despite making up roughly one quarter of the patients with inflammatory bowel diseases (IBD) in the United States, older adults are an understudied population. Chronic steroid use may be as high as 40% in this… read more here.
Keywords: disease; treatment; younger adults; mucosal healing ... See more keywords
Heat shock transcription factor 2 predicts mucosal healing and promotes mucosal repair of ulcerative colitis
Sign Up to like & getrecommendations! Published in 2020 at "Scandinavian Journal of Gastroenterology"
DOI: 10.1080/00365521.2020.1774924
Abstract: Abstract Background: Mucosal healing(MH) is a treatment goal in ulcerative colitis (UC). Our previous studies showed heat shock transcription factor 2 (HSF2) was positively correlated with the activity of UC and had anti-inflammatory potential in… read more here.
Keywords: heat shock; shock transcription; mucosal healing; transcription factor ... See more keywords
P380 Comparison of mucosal healing through segments of ileocolonic Crohn’s disease treated with biologics
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjab076.504
Abstract: Although major advances in Inflammatory bowel disease’s treatment have been observed, the response to the pharmacologic therapies is still unpredictable and highly variable. Mucosal healing (MH) is an important endpoint in Crohn’s disease patients undergoing… read more here.
Keywords: response; ileal colonic; disease; mucosal healing ... See more keywords
Accuracy of Diffusion-weighted Magnetic Resonance Imaging in Detecting Mucosal Healing and Treatment Response, and in Predicting Surgery, in Crohn’s Disease
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjy098
Abstract: Background and Aims The Nancy score is a luminal Crohn's disease [CD] activity index applied in diffusion-weighted magnetic resonance imaging [DW-MRI]. We assessed the accuracy of the Nancy score in detecting mucosal healing and treatment… read more here.
Keywords: score; mucosal healing; healing treatment; nancy score ... See more keywords
Infliximab Trough Levels Are Associated With Mucosal Healing During Maintenance Treatment With Infliximab in Paediatric Crohn’s Disease
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DOI: 10.1093/ecco-jcc/jjy155
Abstract: Background and Aims Mucosal healing is an important treatment goal in Crohn's disease. We investigated the association between serum infliximab trough levels and mucosal healing, and the infliximab cut-off levels required for mucosal healing in… read more here.
Keywords: infliximab trough; trough levels; mucosal healing; crohn disease ... See more keywords
Higher Ustekinumab Levels in Maintenance Therapy are Associated with Greater Mucosal Healing and Mucosal Response in Crohn's Disease: An Experience of 2 IBD Centers.
Sign Up to like & getrecommendations! Published in 2023 at "Inflammatory bowel diseases"
DOI: 10.1093/ibd/izad073
Abstract: BACKGROUND Ustekinumab (UST), a human monoclonal antibody that binds the p40 subunit of interleukin 12 (IL-12) and IL-23, is licensed for induction and maintenance therapy of moderate to severe inflammatory bowel disease (IBD). To date,… read more here.
Keywords: mucosal response; mucosal healing; response; crohn disease ... See more keywords
USEFULLNESS OF SERUM LEUCINE-RICH ALPHA2-GLYCOPROTEIN AND FECAL CALPROTECTIN ASSURROGATE MARKERS IN ULCERATIVE COLITIS
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DOI: 10.1093/ibd/izae020.053
Abstract: Serum Leucine-rich alpha-2 glycoprotein (LRG) was identified as a novel biomarker for rheumatoid arthritis and IBD by using a proteomics approach. Several studies have suggested that serum LRG levels and fecal calprotectin (fCal) were correlated… read more here.
Keywords: leucine rich; serum leucine; mucosal healing; colitis ... See more keywords
Baseline Assessment of Serum Cytokines Predicts Clinical and Endoscopic Response to Ustekinumab in Patients With Crohn's Disease: A Prospective Pilot Study.
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DOI: 10.1093/ibd/izae133
Abstract: BACKGROUND No biomarkers are currently available to predict therapeutic response to ustekinumab (UST) in Crohn's disease (CD). The aim of this prospective study was to identify 1 or more cytokines able to predict mucosal healing… read more here.
Keywords: response ustekinumab; crohn disease; serum; response ... See more keywords