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Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.486
Abstract: Despite remarkable progress in cutaneous melanoma genomic profiling, the mutational landscape of primary mucosal melanomas (PMM) remains unclear. Forty-six PMMs underwent targeted exome sequencing of 111 cancer-associated genes. Seventy-six somatic nonsynonymous mutations in 42 genes…
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Keywords:
inhibition;
braf;
braf fusion;
mucosal melanomas ... See more keywords
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1
Published in 2022 at "Expert Opinion on Orphan Drugs"
DOI: 10.1080/21678707.2022.2134776
Abstract: ABSTRACT Introduction Mucosal melanomas are rare and aggressive forms of cancer that have consistently eluded meaningful recovery with various anticancer therapies. Patients with unresectable mucosal melanomas have benefited from prolonged survival with the use of…
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Keywords:
targeting pathway;
mucosal melanomas;
treatment mucosal;
pathway treatment ... See more keywords
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2
Published in 2022 at "Histopathology"
DOI: 10.1111/his.14843
Abstract: Primary head/neck mucosal melanomas (MMs) are rare and exhibit aggressive biologic behaviour and elevated mutational loads. The molecular mechanisms responsible for high genomic instability observed in head/neck MMs remain elusive. The DNA cytosine deaminase APOBEC3B…
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Keywords:
neck;
dna;
mucosal melanomas;
head neck ... See more keywords
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Published in 2019 at "Oncotarget"
DOI: 10.18632/oncotarget.26584
Abstract: Introduction Clinical outcomes for mucosal melanomas are often poor due to a lack of effective systemic drug therapies. Identifying driver genes in mucosal melanoma may enhance the understanding of disease pathogenesis and provide novel opportunities…
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Keywords:
sf3b1;
mucosal melanoma;
sf3b1 mutations;
mucosal ... See more keywords
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2
Published in 2023 at "Cancers"
DOI: 10.3390/cancers15051356
Abstract: Simple Summary This review provides an updated overview about molecular features, clinical advancements and therapeutic directions of the primary mucosal melanoma which represents a rare and heterogeneous malignancy characterized by a poor prognosis. Abstract Primary…
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Keywords:
mucosal melanomas;
current trends;
trends mucosal;
melanomas overview ... See more keywords