A novel antigen of Mycobacterium tuberculosis and MPLA adjuvant co-entrapped into PLGA:DDA hybrid nanoparticles stimulates mucosal and systemic immunity.
Sign Up to like & getrecommendations! Published in 2018 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2018.10.023
Abstract: BACKGROUND Due to initiation of Mycobacterium tuberculosis infection via the mucosal tissue of the respiratory tract, intranasal administration of new tuberculosis vaccines is highly regarded to enhance mucosal immunity. Our outline was evaluation of mucosal… read more here.
Keywords: plga dda; mpla; tuberculosis; mucosal systemic ... See more keywords
Mucosal and systemic neutralizing antibodies to norovirus induced in infant mice orally inoculated with recombinant rotaviruses
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2214421120
Abstract: Significance Mucosal immunity is a key component of protection against many pathogens. Robust and effective mucosal immune responses are generally induced following infection with a replication-competent pathogen at a mucosal surface. Several studies have attempted… read more here.
Keywords: recombinant rotaviruses; neutralizing antibodies; systemic neutralizing; mucosal systemic ... See more keywords
Early mucosal IFN-α, IP-10, and IL-1RA and synchronized mucosal and systemic immune responses mediate COVID-19 disease progression
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DOI: 10.1128/mbio.01491-25
Abstract: ABSTRACT Mucosal immunity plays a crucial role in protection against respiratory viruses. However, the mechanisms underlying mucosal responses and their impact on COVID-19 outcomes are not well understood, as mucosal immunity is compartmentalized and not… read more here.
Keywords: mucosal; covid disease; immune responses; systemic immune ... See more keywords