Synthetic Colonic Mucus Enables the Development of Modular Microbiome Organoids
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202402514
Abstract: The human colon is home to trillions of microorganisms that modulate gastrointestinal physiology. The understanding of how this gut ecosystem impacts human health, although evolving, is slowed by the lack of accessible tools suitable to… read more here.
Keywords: microbiome; enables development; mucus enables; mucus ... See more keywords
Low Molecular Weight Alginate Oligosaccharides as Alternatives to PEG for Enhancement of the Diffusion of Cationic Nanoparticles Through Cystic Fibrosis Mucus
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202400510
Abstract: Airway mucus is a major barrier to the delivery of lipid‐based nanoparticles in chronic airway diseases such as cystic fibrosis (CF). Receptor‐Targeted Nanocomplexes (RTN), comprise mixtures of cationic lipids and bifunctional peptides with receptor‐targeting and… read more here.
Keywords: alginate oligosaccharides; mucus; cystic fibrosis; rtns ... See more keywords
Mucus Penetrating and Cell‐Binding Polyzwitterionic Micelles as Potent Oral Nanomedicine for Cancer Drug Delivery
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202109189
Abstract: Orally administrable anticancer nanomedicines are highly desirable due to their easy and repeatable administration, but are not yet feasible because the current nanomedicine cannot simultaneously overcome the strong mucus and villi barriers and thus have… read more here.
Keywords: mucus penetrating; mucus; oral nanomedicine; cell binding ... See more keywords
Airway obstruction in respiratory viral infections due to impaired mucociliary clearance.
Sign Up to like & getrecommendations! Published in 2023 at "International journal for numerical methods in biomedical engineering"
DOI: 10.1002/cnm.3707
Abstract: Respiratory viral infections, such as SARS-CoV-2 or influenza, can lead to impaired mucociliary clearance in the bronchial tree due to increased mucus viscosity and its hyper-secretion. We develop in this work a mathematical model to… read more here.
Keywords: viral infections; respiratory viral; mucus; impaired mucociliary ... See more keywords
Vocal fold mucus layer: Comparison of histological protocols for visualization in mice
Sign Up to like & getrecommendations! Published in 2022 at "Laryngoscope Investigative Otolaryngology"
DOI: 10.1002/lio2.743
Abstract: The epithelial associated mucus layer of vocal fold (VF) mucosa, plays an essential role in protecting and lubricating the tissue, as well as promoting normal voice quality. Serving as a habitat for laryngeal microbiota involved… read more here.
Keywords: layer comparison; vocal fold; fold mucus; mucus ... See more keywords
Systematic study of enzymatic degradation and plasmid DNA complexation of mucus penetrating star-shaped lysine/sarcosine polypept(o)ides with different block arrangements.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202200175
Abstract: 8-Arm star polypep(o)ides comprising cationic polylysine and hydrophilic polysarcosine blocks with a degree of polymerization of 30 per block are synthesized. Two different block sequences with polylysine as the inner and polysarcosine as the outer… read more here.
Keywords: star; plasmid dna; different block; mucus ... See more keywords
Cy3-based nanoviscosity determination of mucus: Effect of mucus collection methods and antibiotics treatment.
Sign Up to like & getrecommendations! Published in 2024 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202300437
Abstract: The integrity of the protective mucus layer as a primary defense against pathogen invasion and microbial leakage into the intestinal epithelium can be compromised by the effects of antibiotics on the commensal microbiome. Changes in… read more here.
Keywords: cy3; integrity; mucus; mucus collection ... See more keywords
Microbial diversity of garden snail mucus
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DOI: 10.1002/mbo3.1263
Abstract: The search for new natural compounds for application in medicine and cosmetics is a trend in biotechnology. One of the sources of such active compounds is the snail mucus. Snail physiology and the biological activity… read more here.
Keywords: mucus; garden snail; snail mucus; diversity garden ... See more keywords
Mucus obstruction and inflammation in early cystic fibrosis lung disease: Emerging role of the IL‐1 signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric Pulmonology"
DOI: 10.1002/ppul.24462
Abstract: Mucus plugging constitutes a nutrient‐rich nidus for a bacterial infection that has long been recognized as a potent stimulus for neutrophilic airway inflammation driving progressive lung damage in people with cystic fibrosis (CF). However, mucus… read more here.
Keywords: signaling pathway; lung disease; inflammation; mucus ... See more keywords
Mucus, mucins, and cystic fibrosis
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric Pulmonology"
DOI: 10.1002/ppul.24530
Abstract: Cystic fibrosis (CF) is both the most common and most lethal genetic disease in the Caucasian population. CF is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene and is characterized by… read more here.
Keywords: cystic fibrosis; mucins cystic; disease; mucus ... See more keywords
Microscopic Cascading Devices for Boosting Mucus Penetration in Oral Drug Delivery-Micromotors Nesting Inside Microcontainers.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202206330
Abstract: In the case of macromolecules and poorly permeable drugs, oral drug delivery features low bioavailability and low absorption across the intestinal wall. Intestinal absorption can be improved if the drug formulation could be transported close… read more here.
Keywords: oral drug; mms; mucus; drug delivery ... See more keywords