Compromised Ileal Mucus Barrier Due to Impaired Epithelial Homeostasis Caused by Notch1 Signaling in Cirrhotic Rats
Sign Up to like & getrecommendations! Published in 2020 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-020-06178-6
Abstract: Background In liver cirrhosis, intestinal mucus barrier is rarely studied. Aims This study aimed to investigate whether mucus barrier in ileum is altered in cirrhotic rats and its underlying mechanisms. Methods Thioacetamide was injected to… read more here.
Keywords: ls174t cells; ileal mucus; mucus barrier; cirrhotic rats ... See more keywords
Thiolated nanoparticles overcome the mucus barrier and epithelial barrier for oral delivery of insulin.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.9b00971
Abstract: Oral administration is an ideal alternative for drug delivery due to its convenience and safety. However, oral protein delivery is limited by biological barriers such as mucus barrier and epithelial barrier, which hamper drugs entering… read more here.
Keywords: insulin; mucus barrier; delivery; barrier epithelial ... See more keywords
Acute Exposure to Commonly Ingested Emulsifiers Alters Intestinal Mucus Structure and Transport Properties
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-27957-2
Abstract: The consumption of generally regarded as safe emulsifiers has increased, and has been associated with an increased prevalence of inflammatory bowel and metabolic diseases, as well as an altered microbiome. The mucus barrier, which selectively… read more here.
Keywords: mucus barrier; transport; exposure; acute exposure ... See more keywords
Gut microbiota-derived butyrate regulates gut mucus barrier repair by activating the macrophage/WNT/ERK signaling pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical science"
DOI: 10.1042/cs20210778
Abstract: Ulcerative colitis (UC) is majorly associated with dysregulation of the dynamic cross-talk among microbial metabolites, intestinal epithelial cells, and macrophages. Several studies have reported the significant role of butyrate in host-microbiota communication. However, whether butyrate… read more here.
Keywords: macrophage; goblet; butyrate; goblet cell ... See more keywords
PPARγ: The Central Mucus Barrier Coordinator in Ulcerative Colitis.
Sign Up to like & getrecommendations! Published in 2021 at "Inflammatory bowel diseases"
DOI: 10.1093/ibd/izaa273
Abstract: Ulcerative colitis (UC) is an idiopathic, long-term inflammatory disorder of the colon, characterized by a continuous remitting and relapsing course. The intestinal mucus barrier is the first line at the interface between the host and… read more here.
Keywords: ppar central; mucus barrier; ulcerative colitis; mucus ... See more keywords
Elevated miR‐124‐3p in the aging colon disrupts mucus barrier and increases susceptibility to colitis by targeting T‐synthase
Sign Up to like & getrecommendations! Published in 2020 at "Aging Cell"
DOI: 10.1111/acel.13252
Abstract: The risk of colitis and colorectal cancer increases markedly throughout adult life, endangering the health and lives of elderly individuals. Previous studies have proposed that bacterial translocation and infection are the main risk factors for… read more here.
Keywords: mucus barrier; synthase; targeting synthase; colitis ... See more keywords
A sticky end for gastrointestinal helminths; the role of the mucus barrier
Sign Up to like & getrecommendations! Published in 2018 at "Parasite Immunology"
DOI: 10.1111/pim.12517
Abstract: Gastrointestinal (GI) nematodes are a group of successful multicellular parasites that have evolved to coexist within the intestinal niche of multiple species. It is estimated that over 10% of the world's population are chronically infected… read more here.
Keywords: role mucus; nematode infections; mucus barrier; mucus ... See more keywords
Smoking induces shifts in cellular composition and transcriptome within the bronchial mucus barrier
Sign Up to like & getrecommendations! Published in 2022 at "Respirology"
DOI: 10.1111/resp.14401
Abstract: Smoking disturbs the bronchial‐mucus‐barrier. This study assesses the cellular composition and gene expression shifts of the bronchial‐mucus‐barrier with smoking to understand the mechanism of mucosal damage by cigarette smoke exposure. We explore whether single‐cell‐RNA‐sequencing (scRNA‐seq)… read more here.
Keywords: cellular composition; bronchial mucus; mucus barrier;
An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier function
Sign Up to like & getrecommendations! Published in 2021 at "Science"
DOI: 10.1126/science.abb1590
Abstract: Goblet cell diversity An adult human has a gut surface area averaging 30 square meters that is bombarded daily by xenobiotics and microorganisms. Mucus synthesized by goblet cells supplies a protective barrier coating. Nyström et… read more here.
Keywords: mucus barrier; surface; mucus; colitis ... See more keywords
A Novel Nomogram Combining Mucus Barrier Index for Predicting Treatment Failures in Ulcerative Colitis
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s410057
Abstract: Background Treatment failures (TFs) generally exist in the course of ulcerative colitis (UC), while early reliable predictors of TFs are still lacking. We aimed to generate nomograms for the prediction of TFs. Methods In this… read more here.
Keywords: index; treatment failures; mucus barrier; ulcerative colitis ... See more keywords
Interactions between microbiota and cervical epithelial, immune, and mucus barrier
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2023.1124591
Abstract: The female reproductive tract harbours hundreds of bacterial species and produces numerous metabolites. The uterine cervix is located between the upper and lower parts of the female genital tract. It allows sperm and birth passage… read more here.
Keywords: barrier; mucus barrier; immune mucus; cervical epithelial ... See more keywords