Mucus Penetrating and Cell‐Binding Polyzwitterionic Micelles as Potent Oral Nanomedicine for Cancer Drug Delivery
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202109189
Abstract: Orally administrable anticancer nanomedicines are highly desirable due to their easy and repeatable administration, but are not yet feasible because the current nanomedicine cannot simultaneously overcome the strong mucus and villi barriers and thus have… read more here.
Keywords: mucus penetrating; mucus; oral nanomedicine; cell binding ... See more keywords
The impact of gastrointestinal mucus on nanoparticle penetration – in vitro evaluation of mucus‐penetrating nanoparticles for photodynamic therapy
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2019.03.010
Abstract: Abstract Over the last years nanoparticles (NP) have become a promising vehicle as drug delivery systems for photodynamic therapy (PDT), combining the advantages of an effective drug transport to the target cells and the reduction… read more here.
Keywords: photodynamic therapy; vitro evaluation; mucus penetrating; drug ... See more keywords
Surface-Engineered Mucus Penetrating Nucleic Acid Delivery Systems with Cell Penetrating Peptides for the Lungs.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.1c00770
Abstract: Nucleic acids, both DNA and small RNAs, have emerged as potential therapeutics for the treatment of various lung disorders. However, delivery of nucleic acids to the lungs is challenging due to the barrier property imposed… read more here.
Keywords: mucus penetrating; cell penetrating; mucus; nucleic acid ... See more keywords
pH-Responsive Mucus-Penetrating Nanoparticles for Enhanced Cellular Internalization by Local Administration in Vaginal Tissue.
Sign Up to like & getrecommendations! Published in 2023 at "ACS macro letters"
DOI: 10.1021/acsmacrolett.2c00639
Abstract: Low mucus penetration ability and cellular uptake seriously limit the effectiveness of local vaginal drug administration because of the rapid foreign particulate and pathogen removal property of the mucus layer. Our previous work proved that… read more here.
Keywords: administration; penetrating nanoparticles; mucus penetrating; responsive mucus ... See more keywords
Mucus-Penetrating Alginate-Chitosan Nanoparticles Loaded with Berberine Hydrochloride for Oral Delivery to the Inflammation Site of Ulcerative Colitis
Sign Up to like & getrecommendations! Published in 2022 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-022-02327-4
Abstract: The rectal enemas of berberine hydrochloride (BH) have emerged as one of the most effective strategies in the clinical treatment of ulcerative colitis (UC). However, oral dosages of BH exhibit a poor anti-inflammatory effect of… read more here.
Keywords: alginate chitosan; mucus penetrating; mucus; ulcerative colitis ... See more keywords
Mucus-Penetrating Silk Fibroin-Based Nanotherapeutics for Efficient Treatment of Ulcerative Colitis
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12091263
Abstract: Oral nanoparticles have been considered a prospective drug delivery carrier against ulcerative colitis (UC). To enhance the mucus-penetrating capacity and aqueous solubility, and strengthen the anti-inflammatory effect of resveratrol (RSV), we fabricated RSV-loaded silk fibroin-based… read more here.
Keywords: mucus penetrating; silk fibroin; rsv loaded; ulcerative colitis ... See more keywords