Multi-ancestry meta-analysis and fine-mapping in Alzheimer's Disease
Sign Up to like & getrecommendations! Published in 2022 at "Molecular psychiatry"
DOI: 10.1101/2022.08.04.22278442
Abstract: Genome-wide association studies (GWAS) of Alzheimer's disease are predominantly carried out in European ancestry individuals despite the known variation in genetic architecture and disease prevalence across global populations. We leveraged published and de novo GWAS… read more here.
Keywords: meta analysis; ancestry; disease; alzheimer disease ... See more keywords
Multi‐ancestry genome‐wide association study of asthma exacerbations
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Allergy and Immunology"
DOI: 10.1111/pai.13802
Abstract: Asthma exacerbations are a serious public health concern due to high healthcare resource utilization, work/school productivity loss, impact on quality of life, and risk of mortality. The genetic basis of asthma exacerbations has been studied… read more here.
Keywords: asthma exacerbations; multi ancestry; genome wide; wide association ... See more keywords
Therapeutic Outcomes Wide Association Scan of different antipsychotics in patients with schizophrenia: randomized clinical trials and multi-ancestry validation.
Sign Up to like & getrecommendations! Published in 2023 at "Psychiatry and clinical neurosciences"
DOI: 10.1111/pcn.13567
Abstract: AIM This study identified discrepant therapeutic outcomes of antipsychotics. METHODS A total of 5191 patients with schizophrenia were enrolled, 3030 as discovery cohort, 1395 as validation cohort, and 766 as multi-ancestry validation cohort. Therapeutic Outcomes… read more here.
Keywords: higher risk; validation; multi ancestry; risk ... See more keywords
Leveraging Multi-Ancestry Polygenic Risk Scores for Body Mass Index to Predict Antiretroviral Therapy-Induced Weight Gain*
Sign Up to like & getrecommendations! Published in 2022 at "Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing"
DOI: 10.1142/9789811270611_0022
Abstract: Widespread availability of antiretroviral therapies (ART) for HIV-1 have generated considerable interest in understanding the pharmacogenomics of ART. In some individuals, ART has been associated with excessive weight gain, which disproportionately affects women of African… read more here.
Keywords: multi ancestry; gain; risk; art ... See more keywords
Association of Maternal Metabolites and Metabolite Networks with Newborn Outcomes in a Multi-Ancestry Cohort
Sign Up to like & getrecommendations! Published in 2023 at "Metabolites"
DOI: 10.3390/metabo13040505
Abstract: The in utero environment is important for newborn size at birth, which is associated with childhood adiposity. We examined associations between maternal metabolite levels and newborn birthweight, sum of skinfolds (SSF), and cord C-peptide in… read more here.
Keywords: newborn outcomes; ancestry cohort; multi ancestry; maternal metabolites ... See more keywords