Validity of European-centric cardiometabolic polygenic scores in multi-ancestry populations
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Human Genetics"
DOI: 10.1038/s41431-023-01517-3
Abstract: Polygenic scores (PGSs) provide an individual level estimate of genetic risk for any given disease. Since most PGSs have been derived from genome wide association studies (GWASs) conducted in populations of White European ancestry, their… read more here.
Keywords: multi ancestry; european centric; validity european; ancestry ... See more keywords
An ensemble penalized regression method for multi-ancestry polygenic risk prediction
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-47357-7
Abstract: Great efforts are being made to develop advanced polygenic risk scores (PRS) to improve the prediction of complex traits and diseases. However, most existing PRS are primarily trained on European ancestry populations, limiting their transferability… read more here.
Keywords: multi ancestry; polygenic risk; prediction; usepackage ... See more keywords
Multi-ancestry meta-analysis and fine-mapping in Alzheimer's Disease
Sign Up to like & getrecommendations! Published in 2022 at "Molecular psychiatry"
DOI: 10.1101/2022.08.04.22278442
Abstract: Genome-wide association studies (GWAS) of Alzheimer's disease are predominantly carried out in European ancestry individuals despite the known variation in genetic architecture and disease prevalence across global populations. We leveraged published and de novo GWAS… read more here.
Keywords: meta analysis; ancestry; disease; alzheimer disease ... See more keywords
Multi‐ancestry genome‐wide association study of asthma exacerbations
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Allergy and Immunology"
DOI: 10.1111/pai.13802
Abstract: Asthma exacerbations are a serious public health concern due to high healthcare resource utilization, work/school productivity loss, impact on quality of life, and risk of mortality. The genetic basis of asthma exacerbations has been studied… read more here.
Keywords: asthma exacerbations; multi ancestry; genome wide; wide association ... See more keywords
Therapeutic Outcomes Wide Association Scan of different antipsychotics in patients with schizophrenia: randomized clinical trials and multi-ancestry validation.
Sign Up to like & getrecommendations! Published in 2023 at "Psychiatry and clinical neurosciences"
DOI: 10.1111/pcn.13567
Abstract: AIM This study identified discrepant therapeutic outcomes of antipsychotics. METHODS A total of 5191 patients with schizophrenia were enrolled, 3030 as discovery cohort, 1395 as validation cohort, and 766 as multi-ancestry validation cohort. Therapeutic Outcomes… read more here.
Keywords: higher risk; validation; multi ancestry; risk ... See more keywords
Analysis of left ventricular mass for African American individuals using multi-ancestry polygenic risk scores: the Jackson Heart Study
Sign Up to like & getrecommendations! Published in 2025 at "Open Heart"
DOI: 10.1136/openhrt-2025-003501
Abstract: Background Left ventricular mass (LVM) is suggested to be a sensitive predictor of adverse cardiovascular outcomes, such as heart failure. In recent years, genome-wide association studies have discovered loci that associate with outcomes related to… read more here.
Keywords: multi ancestry; lvm; heart; african american ... See more keywords
Leveraging Multi-Ancestry Polygenic Risk Scores for Body Mass Index to Predict Antiretroviral Therapy-Induced Weight Gain*
Sign Up to like & getrecommendations! Published in 2022 at "Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing"
DOI: 10.1142/9789811270611_0022
Abstract: Widespread availability of antiretroviral therapies (ART) for HIV-1 have generated considerable interest in understanding the pharmacogenomics of ART. In some individuals, ART has been associated with excessive weight gain, which disproportionately affects women of African… read more here.
Keywords: multi ancestry; gain; risk; art ... See more keywords
Abstract 074: Uncovering Hundreds of New Loci from a Multi-Ancestry Study of Blood Pressure Traits in Over 2.5M Individuals
Sign Up to like & getrecommendations! Published in 2025 at "Hypertension"
DOI: 10.1161/hyp.82.suppl_1.074
Abstract: Introduction: Elevated blood pressure (BP) is a leading contributor to global morbidity and mortality, with notable ancestral and racial differences in BP traits in the United States and globally. To date, most BP genome-wide association… read more here.
Keywords: multi ancestry; pressure traits; ancestry; blood pressure ... See more keywords
Multi-ancestry genome-wide meta-analysis with 472,819 individuals identifies 32 novel risk loci for psoriasis
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-024-06015-8
Abstract: Psoriasis is a common chronic, recurrent, immune-mediated disease involved in the skin or joints or both. However, deeper insight into the genetic susceptibility of psoriasis is still unclear. Here we performed the largest multi-ancestry meta-analysis… read more here.
Keywords: multi ancestry; meta analysis; genome wide; psoriasis ... See more keywords
Characterizing common and rare variations in non-traditional glycemic biomarkers using multivariate approaches on multi-ancestry ARIC study.
Sign Up to like & getrecommendations! Published in 2024 at "Diabetes"
DOI: 10.2337/db23-0318
Abstract: Genetic studies of non-traditional glycemic biomarkers, glycated albumin and fructosamine, can shed light on unknown aspects of type 2 diabetes genetics and biology. We performed a multi-phenotype GWAS of glycated albumin and fructosamine from 7,395… read more here.
Keywords: multi ancestry; traditional glycemic; glycemic biomarkers; type diabetes ... See more keywords
Association of Maternal Metabolites and Metabolite Networks with Newborn Outcomes in a Multi-Ancestry Cohort
Sign Up to like & getrecommendations! Published in 2023 at "Metabolites"
DOI: 10.3390/metabo13040505
Abstract: The in utero environment is important for newborn size at birth, which is associated with childhood adiposity. We examined associations between maternal metabolite levels and newborn birthweight, sum of skinfolds (SSF), and cord C-peptide in… read more here.
Keywords: newborn outcomes; ancestry cohort; multi ancestry; maternal metabolites ... See more keywords