An order restricted multi‐arm multi‐stage clinical trial design
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DOI: 10.1002/sim.9314
Abstract: One family of designs that can noticeably improve efficiency in later stages of drug development are multi‐arm multi‐stage (MAMS) designs. They allow several arms to be studied concurrently and gain efficiency by dropping poorly performing… read more here.
Keywords: multi arm; arm multi; multi stage; multi ... See more keywords
Group sequential multi‐arm multi‐stage trial design with treatment selection
Sign Up to like & getrecommendations! Published in 2023 at "Statistics in Medicine"
DOI: 10.1002/sim.9682
Abstract: A multi‐arm trial allows simultaneous comparison of multiple experimental treatments with a common control and provides a substantial efficiency advantage compared to the traditional randomized controlled trial. Many novel multi‐arm multi‐stage (MAMS) clinical trial designs… read more here.
Keywords: multi; multi arm; group sequential; trial ... See more keywords
A Bayesian multi-arm multi-stage clinical trial design incorporating information about treatment ordering.
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DOI: 10.1002/sim.9752
Abstract: Multi-Arm Multi-Stage (MAMS) designs can notably improve efficiency in later stages of drug development, but they can be suboptimal when an order in the effects of the arms can be assumed. In this work, we… read more here.
Keywords: multi arm; arm multi; multi stage; multi ... See more keywords
Fully order restricted multi-arm multi-stage clinical trial design.
Sign Up to like & getrecommendations! Published in 2023 at "Statistics in medicine"
DOI: 10.1002/sim.9767
Abstract: We consider a multi-arm trial with two or more active treatments plus a control where it is reasonable to assume an order for the treatment effects of the active arms compared to control. For example,… read more here.
Keywords: multi arm; trial; design; stage ... See more keywords
Multi-arm response-adaptive designs for circular responses
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DOI: 10.1016/j.jkss.2019.03.005
Abstract: Abstract A multi-arm response-adaptive allocation design is developed for circular treatment outcomes. Several exact and asymptotic properties of the design are studied. Stage-wise treatment selection procedures based on the proposed response-adaptive design are also suggested… read more here.
Keywords: response; designs circular; response adaptive; arm response ... See more keywords
Multi-arm RNA junctions encoding molecular logic unconstrained by input sequence for versatile cell-free diagnostics
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DOI: 10.1038/s41551-022-00857-7
Abstract: Applications of RNA-based molecular logic have been hampered by sequence constraints imposed on the input and output of the circuits. Here we show that the sequence constraints can be substantially reduced by appropriately encoded multi-arm… read more here.
Keywords: input; molecular logic; sequence; multi arm ... See more keywords
Phenylboronic acid-modified nanoscale multi-arm polymers for tumor-targeted therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Biomaterials science"
DOI: 10.1039/d3bm00315a
Abstract: Unimolecular polymer nanomaterials (UPNs) have well-defined structures, desirable stability and designable functional groups, and hence exhibit great application potential in drug delivery. However, the syntheses of UPNs are generally time-consuming and tedious, which greatly limit… read more here.
Keywords: multi arm; acid modified; nanoscale multi; phenylboronic acid ... See more keywords
Sample size re-estimation for confirmatory two-stage flexible multi-arm trial with normal outcomes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Statistical Computation and Simulation"
DOI: 10.1080/00949655.2019.1675070
Abstract: ABSTRACT The need for efficient clinical trial designs has led to the development of flexible multi-arm designs. In this paper, we investigated sample size re-estimation (SSR) methods for fully flexible designs that allow for any… read more here.
Keywords: multi; trial; multi arm; size estimation ... See more keywords
Simulation optimization for Bayesian multi-arm multi-stage clinical trial with binary endpoints
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biopharmaceutical Statistics"
DOI: 10.1080/10543406.2019.1577682
Abstract: ABSTRACT Multi-arm multi-stage designs, in which multiple active treatments are compared to a control and accumulated information from interim data are used to add or remove arms from the trial, may reduce development costs and… read more here.
Keywords: multi stage; arm multi; multi; multi arm ... See more keywords
Multi-arm multi-stage clinical trials for time-to-event outcomes.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of biopharmaceutical statistics"
DOI: 10.1080/10543406.2021.1979575
Abstract: This paper investigates the use of a general multi-arm multi-stage (MAMS) approach for time-to-event outcomes that would streamline simultaneous comparison of a large number of promising therapies in clinical trials, thus significantly reducing the time… read more here.
Keywords: multi stage; multi; time; multi arm ... See more keywords
The benefits of covariate adjustment for adaptive multi-arm designs
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DOI: 10.1177/09622802221114544
Abstract: Covariate adjustment via a regression approach is known to increase the precision of statistical inference when fixed trial designs are employed in randomized controlled studies. When an adaptive multi-arm design is employed with the ability… read more here.
Keywords: adaptive multi; multi arm; covariate adjustment; adjustment ... See more keywords