Primary care patient interest in joining a planned multi‐cancer early detection clinical trial
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Medicine"
DOI: 10.1002/cam4.7312
Abstract: Clinical trials are being conducted and are being planned to assess the safety and efficacy of multi‐cancer early detection (MCED) tests for use in cancer screening. This study aimed to determine the feasibility of primary… read more here.
Keywords: cancer; primary care; multi cancer; early detection ... See more keywords
Modeled residual current cancer risk after clinical investigation of a positive multi-cancer early detection test result.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer"
DOI: 10.1002/cncr.34747
Abstract: Positive results of a multi‐cancer early detection (MCED) test require confirmatory diagnostic workup. Here, residual current cancer risk (RR) during the process of diagnostic resolution, including situations where the initial confirmatory test does not provide… read more here.
Keywords: residual current; test; cancer early; multi cancer ... See more keywords
Multi-cancer blood testing combined with PET-CT: road for hope to screen for cancer and guide intervention
Sign Up to like & getrecommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-0210-2
Abstract: In a recent study published in Science, Lennon et al. investigated the feasibility and safety of multi-cancer peripheral blood testing in combination with positron emission tomography-computed tomography (PET-CT) imaging to detect cancer in 10,006 women… read more here.
Keywords: test; soc screening; multi cancer; blood ... See more keywords
The impact of cancer expectations on psychological responses following a cancer signal detected result in asymptomatic multi-cancer detection (MCED) testing
Sign Up to like & getrecommendations! Published in 2025 at "British Journal of Cancer"
DOI: 10.1038/s41416-025-03180-5
Abstract: Multi-cancer detection (MCED) blood tests have the potential to screen for early-stage cancers. Understanding how people experience an MCED cancer signal result is vital prior to any future implementation. We explored experiences in a trial… read more here.
Keywords: cancer; history; multi cancer; result ... See more keywords
Cross-platform multi-cancer histopathology classification using local-window vision transformers
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-24791-1
Abstract: Cancer remains one of the leading causes of global mortality, with lung, colon, skin, and breast cancers contributing significantly to the disease burden. Accurate and timely classification of histopathological images is critical for effective diagnosis… read more here.
Keywords: classification; local window; cancer; multi cancer ... See more keywords
Novel germline variant in the histone demethylase and transcription regulator KDM4C induces a multi-cancer phenotype
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Medical Genetics"
DOI: 10.1136/jmedgenet-2021-107747
Abstract: Background Genes involved in epigenetic regulation are central for chromatin structure and gene expression. Specific mutations in these might promote carcinogenesis in several tissue types. Methods We used exome, whole-genome and Sanger sequencing to detect… read more here.
Keywords: histone demethylase; multi cancer; variant; cancer ... See more keywords
Abstract 6093: Evaluation of preanalytical and physiological variables affecting cfDNA-based multi-cancer early detection test
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-6093
Abstract: Background: The multi-cancer early detection (MCED) tests utilizing blood-based circulating cell-free DNA (cfDNA) have gained significant attention in the market as a promising approach for early cancer detection. However, potential effects of preanalytical and physiological… read more here.
Keywords: detection; cancer; multi cancer; test ... See more keywords
Abstract 6425: Evaluation of a plasma cell-free DNA methylation-based multi-cancer detection test
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-6425
Abstract: Blood-based multi-cancer detection (MCD) tests hold promise for early cancer detection. MCDs should demonstrate high specificity, clinically meaningful sensitivity, and provide information to guide clinical diagnostic evaluation. We developed an MCD test that leverages a… read more here.
Keywords: multi cancer; test; cancer; cancer detection ... See more keywords
Abstract PR006: The potential of multi-cancer early detection screening for reducing cancer mortality
Sign Up to like & getrecommendations! Published in 2024 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.liqbiop24-pr006
Abstract: Background: Currently, routine screening is recommended for only four cancer types (i.e., breast, cervical, colorectal, and lung) by the United States Preventive Services Task Force (USPSTF), and two-thirds of incident cancers have no screening guidelines.… read more here.
Keywords: detection; year; cancer; multi cancer ... See more keywords
Significant results from a major multi-year, multi-cancer follow-up study with an enrollment of over 19,000 individuals.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2024.42.16_suppl.10539
Abstract: 10539 Background: Multi-cancer screening has become a major approach for early stage cancer screening and prevention. However, there has been very few reported multi-year, multi-cancer follow-up studies to validate the effectiveness of multi-cancer screening. We… read more here.
Keywords: cancer; year multi; multi cancer; multi ... See more keywords
Blood metabolites–based MCTarg for multi-cancer screening and clinical diagnosis.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2024.42.16_suppl.e15028
Abstract: e15028 Background: Multi-cancer early detection (MCED) tests have emerged as promising tools for reducing cancer-related healthcare costs and mortality. As metabolome is closely linked to the phenotype of bio-individual, metabolomics analysis enables the high throughput… read more here.
Keywords: cancer; clinical diagnosis; multi cancer; cancer screening ... See more keywords