Immunogenic Potential and Therapeutic Efficacy of Multi-Epitope Encapsulated Silk Fibroin Nanoparticles Against Pseudomonas Aeruginosa-Mediated Urinary Tract Infections.
Sign Up to like & getrecommendations! Published in 2023 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202300074
Abstract: Pseudomonas aeruginosa (P. aeruginosa) causing urinary tract infections (UTIs) are a major concern among hospital-acquired infections. The need for an effective vaccine that reduces the infections is imperative. This study aimed to evaluate the efficacy… read more here.
Keywords: efficacy multi; urinary tract; pseudomonas aeruginosa; multi epitope ... See more keywords
A new multi-epitope peptide vaccine induces immune responses and protection against Leishmania infantum in BALB/c mice
Sign Up to like & getrecommendations! Published in 2019 at "Medical Microbiology and Immunology"
DOI: 10.1007/s00430-019-00640-7
Abstract: Visceral leishmaniasis (VL) is a tropical and subtropical disease which is endemic in more than eighty countries around the world. Leishmania infantum is one of the main causative agents of VL disease. Currently, there is… read more here.
Keywords: immune responses; balb mice; vaccine; leishmania ... See more keywords
The Immunogenicity and Immunoprotection of VBP3 Multi-epitope Vaccine Targeting Angiogenesis and Tumor Inhibition in Lung Cancer-Bearing Mice
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-017-9667-4
Abstract: The proangiogenic factors including basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) which work synergistically are essential for tumor angiogenesis and tumor growth. The bFGF/VEGF multi-epitope complex peptide (VBP3) was constructed with… read more here.
Keywords: angiogenesis tumor; tumor; angiogenesis; growth ... See more keywords
Designing Diagnostic Kit for Toxoplasma gondii Based on GRA7, SAG1, and ROP1 Antigens: An In Silico Strategy
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-020-10021-x
Abstract: Toxoplasma gondii is an intracellular protozoan that infects a wide range of mammalians. Commercial diagnostic kits usually use the whole parasite antigen to, which can reduce the specificity of the test. B-cell epitopes are antigenic… read more here.
Keywords: rop1; toxoplasma; gondii; structure ... See more keywords
Computational Design of a Multi-epitope Vaccine Against Clostridium chauvoei: An Immunoinformatics Approach
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-021-10279-9
Abstract: Blackleg is an infectious disease of animals that is commonly caused by Clostridium chauvoei and characterized by localized muscle necrosis. In this study, proteome-mining and immunoinformatics approaches were applied to identify novel antigenic proteins and… read more here.
Keywords: clostridium chauvoei; vaccine; epitope; epitope vaccine ... See more keywords
A conserved multi-epitope-based vaccine designed by targeting hemagglutinin protein of highly pathogenic avian H5 influenza viruses
Sign Up to like & getrecommendations! Published in 2020 at "3 Biotech"
DOI: 10.1007/s13205-020-02544-3
Abstract: The highly pathogenic avian H5N1 influenza viruses have been recognized as a potential pandemic threat to humans, and to the poultry industry since 1997. H5 viruses consist of a high mutation rate, so universal vaccine… read more here.
Keywords: influenza viruses; highly pathogenic; vaccine; pathogenic avian ... See more keywords
Development of multi-epitope peptide-based vaccines against SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2020 at "Biomedical Journal"
DOI: 10.1016/j.bj.2020.09.005
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic involving so far more than 15 million infections and 630,211 deaths. Effective vaccines are urgently needed to prevent SARS-CoV-2 infections. No vaccines have yet… read more here.
Keywords: based vaccines; peptide based; epitope peptide; sars cov ... See more keywords
An in-depth in silico and immunoinformatics approach for designing a potential multi-epitope construct for the effective development of vaccine to combat against SARS-CoV-2 encompassing variants of concern and interest
Sign Up to like & getrecommendations! Published in 2021 at "Computers in Biology and Medicine"
DOI: 10.1016/j.compbiomed.2021.104703
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the latest of the several viral pathogens that have acted as a threat to human health around the world. Thus, to prevent COVID-19 and control the outbreak,… read more here.
Keywords: construct; sars cov; vaccine; development ... See more keywords
An immunoinformatics-based designed multi-epitope candidate vaccine (mpme-VAC/STV-1) against Mycoplasma pneumoniae
Sign Up to like & getrecommendations! Published in 2022 at "Computers in biology and medicine"
DOI: 10.1016/j.compbiomed.2021.105194
Abstract: Pneumonia is a serious global health problem that accounts for over one million deaths annually. Among the main microorganisms causing pneumonia, Mycoplasma pneumoniae is one of the most common ones for which a vaccine is… read more here.
Keywords: vac stv; multi epitope; mpme vac;
Nanoliposomal vaccine containing long multi-epitope peptide E75-AE36 pulsed PADRE-induced effective immune response in mice TUBO model of breast cancer.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of cancer"
DOI: 10.1016/j.ejca.2020.01.010
Abstract: The main goal of peptide-based cancer vaccines is to induce the immune system and activation of effective T cell responses against cancerous cells. Nevertheless, the potency of peptide vaccines is insufficient in most of cases… read more here.
Keywords: padre; epitope peptide; cancer; vaccine ... See more keywords
Robust mucosal and systemic responses against HTLV‐1 by delivery of multi‐epitope vaccine in PLGA nanoparticles
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2018.11.003
Abstract: &NA; In this investigation, the immunogenicity of HTLV‐1 fusion epitope‐loaded PLGA nanoparticles (NPs) was assessed in the absence or presence of co‐encapsulated CpG ODN adjuvant, in a mice model. For this purpose, the multi‐epitope chimera… read more here.
Keywords: plga nanoparticles; chimera; responses htlv; vaccine ... See more keywords