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Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-84117-9
Abstract: FGF19/FGFR4 autocrine signaling is one of the main targets for multi-kinase inhibitors (MKIs). However, the molecular mechanisms underlying FGF19/FGFR4 signaling in the antitumor effects to MKIs in hepatocellular carcinoma (HCC) remain unclear. In this study,…
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Keywords:
fgf19 fgfr4;
hcc;
inhibition;
multi kinase ... See more keywords
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Published in 2022 at "Xenobiotica"
DOI: 10.1080/00498254.2022.2137068
Abstract: Abstract 1. Cytochrome P450 2J2 (CYP2J2) shows high expression in extrahepatic tissues, including the heart and kidney and in tumours. Inhibition of CYP2J2 has attracted attention for cancer treatment because it metabolises arachidonic acid (AA)…
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Keywords:
p450 2j2;
cytochrome p450;
apatinib motesanib;
activity ... See more keywords
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Published in 2022 at "Expert Review of Anticancer Therapy"
DOI: 10.1080/14737140.2022.2102000
Abstract: ABSTRACT Objectives Radioiodine-refractory differentiated thyroid cancer (RAI-rDTC) has frequently been associated with poor prognosis. We conducted a meta-analysis of published randomized controlled trials to evaluate multi-kinase inhibitors’ efficacy and safety profile treatment. Methods A comprehensive…
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Keywords:
refractory differentiated;
meta analysis;
differentiated thyroid;
thyroid cancer ... See more keywords
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Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.264
Abstract: Abstract Central nervous system germ cell tumors (CNS GCTs) are rare intracranial malignancies developing in adolescents and young adults which relatively frequently occur in East Asia region of the world including Japan. However, among CNS…
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Keywords:
kinase inhibitors;
cell;
multi kinase;
germ cell ... See more keywords
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3
Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4027
Abstract: Background: Up to date, over 80 small molecule kinase inhibitors have been approved for the treatment of cancers worldwide. This class of targeted therapy benefits millions of patients by improving their disease management and quality…
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Keywords:
tsn084;
acquired drug;
drug resistant;
multi kinase ... See more keywords
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Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24065496
Abstract: Multi-kinase inhibitors (MKIs) represent the best therapeutic option in advanced thyroid cancer patients. The therapeutic efficacy and toxicity of MKIs are very heterogeneous and are difficult to predict before starting treatment. Moreover, due to the…
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Keywords:
multi kinase;
thyroid cancer;
advanced thyroid;
side effects ... See more keywords