Repression of Primitive Erythroid Program Is Critical for the Initiation of Multi‐Lineage Hematopoiesis in Mouse Development
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.25422
Abstract: Formation of the hematopoietic cells occurs in multiple steps. The first hematopoietic cells observed during ontogeny are primitive erythrocytes, which are produced in the early yolk sac within a limited temporal window. Multi‐lineage hematopoiesis, which… read more here.
Keywords: multi lineage; cell; lineage hematopoiesis; hematopoietic cells ... See more keywords
Wnt signaling promotes hindgut fate commitment through regulating multi-lineage genes during hESC differentiation.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2016.09.009
Abstract: Wnt signaling plays essential roles in both embryonic pattern formation and postembryonic tissue homoestasis. High levels of Wnt activity repress foregut identity and facilitate hindgut fate through forming a gradient of Wnt signaling activity along… read more here.
Keywords: regulating multi; wnt signaling; wnt; multi lineage ... See more keywords
T-Bet+ IgM Memory Cells Generate Multi-lineage Effector B Cells
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.06.074
Abstract: SUMMARY Immunoglobulin M (IgM) memory cells undergo differentiation in germinal centers following antigen challenge, but the full effector cell potential of these cells is unknown. We monitored the differentiation of enhanced yellow fluorescent protein (eYFP)-… read more here.
Keywords: memory cells; multi lineage; igm memory; bet igm ... See more keywords
Multi-lineage Human iPSC-Derived Platforms for Disease Modeling and Drug Discovery.
Sign Up to like & getrecommendations! Published in 2020 at "Cell stem cell"
DOI: 10.1016/j.stem.2020.02.011
Abstract: Human induced pluripotent stem cells (hiPSCs) provide a powerful platform for disease modeling and have unlocked new possibilities for understanding the mechanisms governing human biology, physiology, and genetics. However, hiPSC-derivatives have traditionally been utilized in… read more here.
Keywords: multi lineage; lineage human; human ipsc; disease modeling ... See more keywords
Interpretable machine learning-guided single-cell mapping deciphers multi-lineage pancreatic dysregulation in type 2 diabetes
Sign Up to like & getrecommendations! Published in 2025 at "Cardiovascular Diabetology"
DOI: 10.1186/s12933-025-02865-8
Abstract: Pancreatic cellular heterogeneity is fundamental to systemic metabolic regulation, yet its pathological remodeling in diabetes remains poorly characterized. We integrated single-cell RNA sequencing with machine learning frameworks to decode pancreatic heterogeneity. Novel tools included PanSubPred… read more here.
Keywords: multi lineage; cell; machine learning; single cell ... See more keywords