Multi-omic analysis in carcinoma of unknown primary (CUP): therapeutic impact of knowing the unknown.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular oncology"
DOI: 10.1002/1878-0261.13293
Abstract: Carcinoma of unknown primary (CUP) is a difficult-to-manage malignancy. Multi-omic profiles and treatment outcome versus degree of precision matching was assessed. Tumors underwent next-generation sequencing (NGS) [tissue and/or blood-derived cell-free DNA (cfDNA)]. Selected patients had… read more here.
Keywords: cup; unknown primary; multi omic; analysis ... See more keywords
A multi‐omic approach identifies an autism spectrum disorder (ASD) regulatory complex of functional epimutations in placentas from children born preterm
Sign Up to like & getrecommendations! Published in 2023 at "Autism Research"
DOI: 10.1002/aur.2915
Abstract: Children born preterm are at heightened risk of neurodevelopmental impairments, including Autism Spectrum Disorder (ASD). The placenta is a key regulator of neurodevelopmental processes, though the precise underlying molecular mechanisms remain unclear. Here, we employed… read more here.
Keywords: functional epimutations; multi omic; born preterm; omic approach ... See more keywords
Multi-Omic Approaches to Identify Genetic Factors in Metabolic Syndrome.
Sign Up to like & getrecommendations! Published in 2021 at "Comprehensive Physiology"
DOI: 10.1002/cphy.c210010
Abstract: Metabolic syndrome (MetS) is a highly heritable disease and a major public health burden worldwide. MetS diagnosis criteria are met by the simultaneous presence of any three of the following: high triglycerides, low HDL/high LDL… read more here.
Keywords: complex disease; omic approaches; approaches identify; disease ... See more keywords
Multi-omic and comparative analyses revealed monocyte-derived alpha-defensin-1 correlated with COVID-19 severity and inhibited SARS-CoV-2 infection.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medical virology"
DOI: 10.1002/jmv.28845
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological pathogen of coronavirus disease 2019 (COVID-19), a highly contagious disease, spreading quickly and threatening global public health. The symptoms of COVID-19 vary from mild reactions… read more here.
Keywords: multi omic; defensin; infection; severity ... See more keywords
Mechanistic safety assessment via multi-omic characterisation of systemic pathway perturbations following in vivo MAT2A inhibition
Sign Up to like & getrecommendations! Published in 2024 at "Archives of Toxicology"
DOI: 10.1007/s00204-024-03771-w
Abstract: The tumour suppressor p16/CDKN2A and the metabolic gene, methyl-thio-adenosine phosphorylase (MTAP), are frequently co-deleted in some of the most aggressive and currently untreatable cancers. Cells with MTAP deletion are vulnerable to inhibition of the metabolic… read more here.
Keywords: perturbations following; mat2a; inhibition; multi omic ... See more keywords
Repair mechanisms of bone system tissues based on comprehensive perspective of multi-omics
Sign Up to like & getrecommendations! Published in 2025 at "Cell Biology and Toxicology"
DOI: 10.1007/s10565-025-09995-5
Abstract: Bone disorders affect more than half of the adult population worldwide who may have a poor quality of life and physical independence worldwide. Multi-omic techniques are increasingly adopted and applied to determine the molecular mechanisms… read more here.
Keywords: omic techniques; repair; multi omic; bone ... See more keywords
Simultaneous Multiplexed Imaging of Biomolecules in Transgenic Mouse Brain Tissues Using Mass Spectrometry Imaging: A Multi-omic Approach.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c00676
Abstract: The importance of multi-omic-based approaches to better understand diverse pathological mechanisms including neurodegenerative diseases has emerged. Spatial information can be of great help in understanding how biomolecules interact pathologically and in elucidating target biomarkers for… read more here.
Keywords: information; multi omic; mass spectrometry; omic approach ... See more keywords
Integrative Analysis of Multi-Omic Data for the Characteristics of Endometrial Cancer
Sign Up to like & getrecommendations! Published in 2024 at "ACS Omega"
DOI: 10.1021/acsomega.4c00375
Abstract: Endometrial cancer (EC) is a frequently diagnosed gynecologic cancer. Identifying reliable prognostic genes for predicting EC onset is crucial for reducing patient morbidity and mortality. Here, a comprehensive strategy with transcriptomic and proteomic data was… read more here.
Keywords: cancer; integrative analysis; analysis multi; multi omic ... See more keywords
Multi-omic characterization of allele-specific regulatory variation in hybrid pigs
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-49923-5
Abstract: Genetic variation in the regulation of gene expression contributes substantially to phenotypic variation. Understanding how variation in DNA sequences and epigentic modifications leads to gene expression variation remains a challenging task. In hybrid animals where… read more here.
Keywords: gene expression; variation; multi omic; allele specific ... See more keywords
Multi-omic analysis of Huntington’s disease reveals a compensatory astrocyte state
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-50626-0
Abstract: The mechanisms underlying the selective regional vulnerability to neurodegeneration in Huntington’s disease (HD) have not been fully defined. To explore the role of astrocytes in this phenomenon, we used single-nucleus and bulk RNAseq, lipidomics, HTT… read more here.
Keywords: disease; astrocyte state; huntington disease; multi omic ... See more keywords
An integrated multi-omic natural history study of human development, sexual dimorphism, and the effects of trisomy 21
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-63862-9
Abstract: Human development involves multiple signaling pathways acting concertedly in an age- and sex-specific fashion. Trisomy 21, the genetic cause of Down syndrome, dysregulates human development leading to both early neurodevelopmental delays and atypical accelerated aging… read more here.
Keywords: age; history; human development; sexual dimorphism ... See more keywords